PARENT SESSION 3:45 PM to 5:15 AM Sunday, April 21, 2002 Mini-Symposium 5 Oxygenation and Stress Response Room: Nevada 1-2 , Co-Chair: Koch, Cameron1; Mason, Kathy21University of Pennsylvania, Philadelphia, PA2MD Anderson Cancer Center, Houston, TX
(MS05-1) VEGFR tyrosine kinase inhibition by ZK 222584/ PTK 787 (ZK) combined with fractionated radiotherapy (RT) in human squamous cell carcinoma (hSCC) in nude mice. Zips, Daniel*,1, Krause, Mechthild1, Westphal, Jana1, Brüchner, Kerstin2, Eicheler, Wolfgang1, Dörfler, Annegret1, Grenman, Reidar3, Baumann, Michael1,2, 1 Dept. of Radiation Oncology, Medical Faculty, University of Dresden, Dresden, Germany2 Experimental Center, Medical Faculty, University of Dresden, Dresden, Germany3 Dept. of Otorhinolarynology, Turku University Central Hospital, Turku, Finland
FULL ABSTRACT (MS05-2) Study of hypoxia in human head and neck tumors by pimonidazole binding and HIF-1 alpha expression. Janssen, Hilde*,1, Blommestijn, Gerard1, Sprong, Debbie1, Haustermans, Karin1,2, Semenza, Gregg3, Raleigh, Jim4, Balm, Alfons1, Begg, Adrian1, 1 The Netherlands Cancer Institute, Amsterdam, The Netherlands2 University Hospital Gasthuisberg, Leuven, Belgium3 The Johns Hopkins University School of medicine, Baltimore, Maryland4 UNC-CH School of Medicine, Chapel Hill, North Carolina
FULL ABSTRACT (MS05-3) Comparison of MR imaging and MR spectroscopic parameters with oxygenation, thermometry, and histopathology in 35 patients with high grade soft tissue sarcomas following thermoradiotherapy. Charles, H. Cecil2, McFall, James2, Samulski, Thaddeus1, Brizel, David1, Poulson, Jean1, Yu, Daohai3, Prosnitz, Leonard1, Jones, Ellen1, Dewhirst, Mark1, Lora-Michiels, Michaël*,1, 2 Center for Advanced Magnetic Resonance Development1 Department of Radiation Oncology3 Department of Biostatistics and Bioinformatics, Durham, NC
FULL ABSTRACT (MS05-4) Isoform specificity of redox-mediated TGF- activation. Jobling, Michael*,1, Finnigan, Monica1, Barcellos-Hoff, Mary Helen1, 1 Cell and Molecular Biology, Berkeley, CA
FULL ABSTRACT (MS05-5) Protection from radiation induced acute lung injury by overexpression of extracellular superoxide dismutase in mice. Kang, Song*,1, Rabbani, Zahid1, Folz, Rodney2, Dewhirst, Mark1, Anscher, Mitchell1, Vujaskovic, Zeljko1, 1 Duke University Medical Center, Durham, NC2 Duke University Medical Center, Durham, NC
FULL ABSTRACT (MS05-6) Requirement for double stranded RNA-dependent protein kinase (PKR) for expression of heat shock proteins during stress involves mRNA stabilization. Tang, Dan*,1, Zhao, Meijuan1, Stevenson, Mary Ann2, Asea, Alexzander1, Calderwood, Stuart1, 1 Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St., Boston, MA2 Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
FULL ABSTRACT (MS05-7) The influence of low dose ionizing radiation on elevated endogenous free radical levels in transgenic growth hormone mice . Lemon, Jennifer*,1, Rollo, C. David1, Boreham, Doug2, 1 Department of Biology, Life Sciences Building, Hamilton, Ontario2 Department of Medical Physics, Nuclear Research Building, Hamilton, Ontario
FULL ABSTRACT (MS05-8) AP-1 activation of DNA methyltransferase contributes to a unique multi-modality resistant phenotype via cellular oxidative stress responses. Sieck, Leah*,1, Bisht, Kheem1, Bradbury, C. Matthew1, Gius, David1, 1 National Cancer Institute, Bethesda, MD
FULL ABSTRACT (MS05-9) Radiation effects on proteasome function. Pervan, Milena*,1, McBride, William1, 1 Department of Radiation Oncology, UCLA, Los Angeles, CA
FULL ABSTRACT
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