PARENT SESSION
1:30 PM to 3:30 PM
Tuesday, April 23, 2002
Poster Session 17 Induced Gene Expression
Room: Nevada Exhibition Center
(P22-235) Low dose alpha radiation effects on cytokine gene expression.
Wilkinson, Diana*,1, Ford, Barry1, Thorleifson, Erika1, Leach, Karen2, Prud'homme-Lalonde, Louise2, Stodilka, Robert2, Tracy, Bliss1, 1 Health Canada, 775 Brookfield Rd, Ottawa, Ontarion2 Department of National Defence, 3701 Carling Ave, Ottawa, Ontarion
ABSTRACT-
Cells exposed to low doses of ionizing radiation undergo a series of biochemical changes that affect not only the functional state of that cell but also that of its neighbours. These changes can affect repair pathways, cell cycle regulation, cell proliferation, or alternatively, induce apoptosis. Bystander effects studies indicate that changes in gene expression caused by cell damage result in an exposition and release of factors that signal adjacent cells that wounding has occurred. Cytokine gene expression changes have been observed following exposure of human lymphoblastoid cells to low dose gamma radiation (Ford et al., Rad. Res. 2001) In this study we are looking at cytokine gene expression changes following exposure of human lymphoblastoid cells to low dose alpha radiation. This work is partially funded by Department of National Defence, Defence Research Establishment Ottawa and the Toxic Substances Research Initiative.
KEYWORDS: gene expression, cytokines, alpha radiation, low dose effects