PARENT SESSION
3:45 PM to 5:15 PM
Sunday, April 21, 2002
Workshop 2
Lessons from the Multicellular World
Room: Nevada 8-9-10
Chair: Wright, Eric²²University of Dundee, Dundee, Scotland, UK, Co-Chair: Barcellos-Hoff, Mary Helen³³Bldg. 74, Berkeley, CA
Speakers: Mothershill, Carmel⁴; Wright, Eric⁵; Barcellos-Hoff, Mary Helen⁶⁴Radiation and Environmental Science Centre, Dublin, Ireland⁵University of Dundee, Dundee, Scotland, UK⁶Bldg. 74, Berkeley, CA

(WS02-) Lessons from the Multicellular World.

Barcellos-Hoff, Mary^*,1, Wright, Eric², Mothershill, Carmel³, ¹ Lawrence Berkeley National Laboratory, Berkeley, CA² University of Dundee, Dundee, Scotland³ Dublin Institute of Technology, Dublin, Ireland

ABSTRACT-
Normal tissue homeostasis is maintained bydynamic interactions between cells and their microenvironment. How are tissues affected when individual cells are damaged by ionizing radiation? Do various cells in situ, e.g. stromal versus epithelial, stromal versus hemopoietic or differentiated versus stem cells, respond uniformly to radiation? Can we view tissue response as a sum of cellular effects such as cell death and DNA damage? Or does tissue respond coherently to the damage of its cellular parts? And do these processes affect how and when cancer occurs? This workshop will focus on interactions between normal cells such as stroma and endothelium, and between cells and their microenvironments following radiation exposure, with a view to predicting which aspects are determinants of cancer.

KEYWORDS: Carcinogenesis, Cell interactions, Genomic instability, Apoptosis