Chemistry and Biology of Deoxyribose Oxidation

Bryant-Friedrich, Amanda^*,1, Lahoud, Georges ¹, ¹ Department of Chemistry, Rochester, MI, United States
(SY061) The role of the C-3′-nucleotide radical in DNA damage.

Razskazovskiy, Yuriy^*,1, Roginskaya, Marina², Bernhard, William², ¹ Physics, Astronomy and Geology, Johnson City, TN, USA² Biochemistry and Biophysics, Rochester, NY, USA
(SY062) Yields and decomposition of 2′-deoxyribonolactone desions in irradiated DNA and chromatin.

Dedon, Peter^*,1, ¹ Biological Engineering Division, Cambridge, MA, USA
(SY063) Chemical approaches to defining the biological consequences of radical-mediated deoxyribose oxidation in DNA.

Demple, Bruce^*,1, ¹ Dept. of Genetics & Complex Diseases, School of Public Health, Boston, MA, USA
(SY064) Ape1, DNA polymerase-beta and the repair of oxidized abasic sites: Roadblocks, detours and divided highways.