PARENT SESSIONGenomic Maintenance & Repair
Monday, October 17, 2005 3:00 PM-5:00 PM Exhibit Hall Al Rashid, Shahnaz*,1, Law, Cindy1, Bristow, Robert1, 2, 1 Department of Medical Biophysics, Toronto, Ontario, Canada2 Department of Radiation Oncology, Toronto, Ontario, Canada
(PP282) The role of p53 carboxy-terminus domains and recruitment to nuclear sites of DNA damage.
Ray, Subrata2, Gupta, Damodar1, 2, Macklis, Roger 1, Almasan, Alex*,1, 2, 2 Cancer Biology/Lerner Research Institute, Cleveland, OH1 Radiation Oncology/Taussig Cancer Center, Cleveland, OH
(PP283) Ionizing radiation-induced G2-checkpoint control by ATR and Chk1 in p53 deficient prostate cancer cells.
Alsbeih, Ghazi*,1, Al-Harbi, Najla1, Torres, Martha1, Al-Buhairi, Muneera1, Al-Hamed, Mohamed2, El-Sebaie, Medhat3, Al-Rajhi, Nasser3, 1 Biomedical Physics Dept., Riyadh, CR, Saudi Arabia2 Aragene, Riyadh, CR, Saudi Arabia3 Radiation Oncology, Riyadh, CR, Saudi Arabia, Saudi Arabia
(PP284) Relationship between protein induction, polymorphisms and radiotherapy complications in Saudi cancer patients.
Bahary, Nathan*,2, Epperly, Michael1, Quadar, Mubina1, Greenberger, Joel1, 2 Molecular Genetics and Biochemistry, Pittsburgh, PA, USA1 Radiation Oncology, Pittsburgh, PA, USA
(PP285) Small molecule antioxidants prevent ionizing irradiation-induced fibrosis in the adult zebrafish.
Balajee, Adayabalam*,1, Baskar, Rajamanickam1, Geard, Charles1, 1 Radiation Oncology, New York, NY, USA
(PP286) Histone H2AX is dispensable for base excision repair activity.
Begg, Adrian*,1, Vermeulen, Christie1, Vens, Conchita1, 1 Experimental Therapy, Amsterdam, NH, Netherlands
(PP287) The role of repair and bypass polymerases in the radiation response.
Bindra, Ranjit*,1, 2, Gibson, Shannon1, 7, Meng, Alice5, 6, Jasin, Maria 3, Pierce, Andrew4, Bristow, Robert5, 6, Classon, Marie7, Glazer, Peter1, 8, 1 Department of Therapeutic Radiology, New Haven, CT, USA2 Department of Experimental Pathology, New Haven, CT, USA7 MGH Cancer Center, Charlestown, MA, USA5 Ontario Cancer Institute, Toronto, Ontario, Canada6 Department of Medical Biophysics, Toronto, Ontario, Canada3 Molecular Biology Program, New York, NY, USA4 Department of Microbiology, Immunology and Molecular Genetics, Lexington, KY, USA8 Department of Genetics, New Haven, CT, USA
(PP288) Stress-induced regulation of BRCA1 expression by E2Fs.
Borgmann, Kerstin*,1, Jend, Camilla1, Streichert, Thomas2, Zschenker, Oliver1, Stürzbecher, Horst3, Dikomey, Ekkehard1, 1 Lab of Radiobiology & Experimental Radiooncology, Clinic of Radiotherapy and Radiooncology, Hamburg, Germany2 Institute of Clinical Chemistry, Hamburg, Germany3 Institute of Human Genetics, Luebeck, Germany
(PP289) Drastic changes in gene expression caused by Rad51 overexpression affects DNA repair only in S/G2- but not in the G1-phase.
Chan, Norman*,1, Meng, Alice1, Jalali, Farid1, Bindra, Ranjit2, Glazer, Peter2, Powell, Simon3, Bristow, Rob1, 1 Department of Medical Biophysics, Toronto, Ontario, Canada2 Department of Therapeutic Radiology, New Haven, CT, USA3 Department of Radiation Oncology, St. Louis, MO, USA
(PP290) DNA double strand break repair and hypoxia-mediated genetic instability.
Chaudhry, Ahmad*,1, 1 Medical Laboratory and Radiation Sciences, Burlington, VT
(PP291) Radiation-induced gene expression profile of human cells deficient in 8-hydroxy-2'-deoxyguanine glycosylase.
Chen, Benjamin*,1, Kobayashi, Junya2, Yajima, Hirihiko 1, Krempler, Andrea 3, Löebrich, Markus 3, Chen, David1, 1 Radiation Oncology/Molecular Radiation Biology, Dallas, TX, USA2 Radiation Biology, Hiroshima, Hiroshima, Japan3 Fachrichtung Biophysik, Homburg, Saar, Germany
(PP292) Differential regulation of IR-induced T2609 and S2056 phosphorylation of DNA-PKcs.
Langland, Gregory1, Guan, Yinghui1, Yannone, Steven1, Shingyoji, Masato1, Long, Sydney1, Vonguyen, Lien1, Chen, David1, Gray, Joe1, Chen, Fanqing*,1, 1 Life Sciences Division, Berkeley, CA, USA
(PP293) Evaluation of p53 and the DNA-dependent protein kinase as predictors of radiation-sensitivity in ovarian cancer cells.
Coleman, Matthew*,1, Pearson, Francesca1, Bourguet, Feliza 1, Jones, Irene1, Wyrobek, Andrew 1, Marchetti, Francesco 1, 1 Biomedical Division, Biosciences Directorate, Livermore, CA, USA
(PP294) Understanding radiation-modulated proteins: an array based approach.
Datta, Kamal*,1, Neumann, Ronald1, Winters, Thomas1, 1 Nuclear Medicine Department/ Warren Grant Magnuson Clinical Center, Bethesda, MD
(PP295) Upstream lesions are a more severe impediment to non-homologous end joining than blocked 3′-ends.
Davidson, William*,1, Kari, Gabor1, Daroczi, Borbala1, Rodeck, Ulrich2, Dicker, Adam1, 1 Radiation Oncology, Philadelphia, Pennsylvania, USA2 Dermatology, Philadelphia, Pennsylvania, USA
(PP296) Knock down of p53 suppresses radiation-induced malformations and enhances zebrafish embryo survival.
De Schutter, Harlinde*,1, Barbé, Barbara1, Spaepen, Marijke2, Janssen, Hilde1, Haustermans, Karin1, Begg, Adrian3, Nuyts, Sandra1, 1 Department of Radiation Oncology, Leuven, Belgium, Belgium2 Centre for Human Genetics, Leuven, Belgium, Belgium3 Experimental Therapy, Amsterdam, The Netherlands, The Netherlands
(PP297) The correlation between hypoxia and microsatellite alterations in head and neck squamous cell carcinoma.
DeMott, Michael*,1, Karadedeli, Betul1, Cosgrove, Joseph1, Dedon, Peter1, 1 Biological Engineering Division, Cambridge, MA, USA
(PP298) Phosphorylation of yeast histone H2A as a biomarker for deoxyribose oxidation in DNA.
Kovalchuk, Olga*,1, Koturbash, Igor 1, Hendricks, Carrie2, Stevenson, Sandie 1, Engelward, Bevin*,2, 1 Department of Biological Sciences, Lethbridge, AB, Canada2 Biological Engineering Division, Cambridge, MA, USA
(PP299) Role of homologous recombination in radiation-induced genome instability, adaptive response and bystander effect in vivo.
Epperly, Michael*,1, Fink, Mitchell2, Hricisak, Lauren1, Zhang, Xichen1, Greenberger, Joel1, 1 Radiation Oncology, Pittsburgh, PA, USA2 Critical Care Medicine, Pittsburgh, PA, USA
(PP300) Incubation of 32D cl 3 factor-dependent hematopoietic cells in ethyl pyruvate (EP) increases radiation resistance.
Fan, Jinjiang*,1, Shen, Zhiyuan1, 1 Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP301) Identification of BISET1, a BCCIP-Interacting SET domain protein.
Miller, Susan1, Ferrarotto, Catherine*,1, Vlahovich, Slavica2, Wilkins, Ruth1, Boreham, Douglas3, Dolling, Jo-Anna3, 4, 1 Consumer and Clinical Radiation Protection Bureau, Ottawa, ON, Canada2 Radiation Protection Bureau, Ottawa, ON, Canada3 McMaster Institute of Applied Radiation Sciences, Hamilton, ON, Canada4 Genetics Department, Mississauga, ON, Canada
(PP302) Canadian Cytogenetic Emergency Network (CEN) for biological dosimetry following radiological/nuclear accidents.
George, Kerry*,1, 3, Durante, Marco 2, Cucinotta, Francis3, 1 Wyle Laboratories, Houston, TX, USA3 NASA, Lyndon B. Johnson Space Center, Houston, TX, USA2 University Federico II, Naples, Italy
(PP303) Chromosome aberrations in the progeny of human lymphocytes exposed to energetic heavy ions.
Gibbons, Catherine*,1, 2, Natarajan, Mohan3, Mohan, Sumathy4, Pandeswara, S3, Moore, Stephen1, Grosovsky, Andrew2, Kadhim, Munira1, 1 Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK2 Environmental Toxicology Graduate Program, Riverside, CA, USA3 Department of Radiation Oncology, San Antonio, TX, USA4 Department of Pathology, San Antonio, TX, USA
(PP304) TNF
as a potential signaling mediator of genomic instability and the bystander effect.
Hagelstrom, R.*,1, Chang, Sandy2, Bailey, Susan1, 1 Environmental and Radiological Health Sciences, Fort Collins, Colorado, United States2 Department of Molecular Genetics, Houston, Texas, United States
(PP305) WRN-deficient cells exhibit unusually high rates of telomeric recombination.
Han, Jianxun*,1, Hendzel, Michael1, 2, Turner, Joan1, 2, 1 Department of Oncology, Edmonton, Alberta, Canada2 Division of Experimental Oncology, Edmonton, Alberta, Canada
(PP306) Extensive and asynchronous H2AX phosphorylation after ionizing irradiation.
Hinz, John*,1, Tebbs, Robert1, Urbin, Salustra1, Nham, Peter1, Salazar, Edmund1, Kopf, Vicki1, Yamada, N.1, Thompson, Larry1, 1 Biosciences Directorate, Livermore, CA, USA
(PP307) Role of Rad51 paralogs in genomic stability and resistance to DNA damage.
Holt, Stewart*,1, Francisco, Dave1, Hada, Megumi1, Georgakilas, Alexandros1, 1 Biology Department, Greenville, NC, USA
(PP308) Detection of oxidative clustered DNA lesions in human cancerous cell lines.
Hopkins, Kevin*,1, Balajee , Adayabalam1, Lieberman, Howard1, 1 Center for Radiological Research, New York, NY
(PP309) Deletion of mouse Rad9 leads to high spontaneous frequencies of sister chromatid exchange.
Joiner, Michael*,1, Krueger, Sarah1, Wright, Jennifer1, Piasentin, Ivano1, Wilson, George1, Marples, Brian1, 1 Department of Radiation Oncology, Detroit, MI, USA
(PP310) Inverse dose rate effects mediated by low-dose hyper-radiosensitivity in prostate cancer cell lines.
Kachnic, Lisa*,1, Willers, Henning1, Li, Li1, Treszezamsky, Alejandro1, Powell, Simon1, 2, 1 Department of Radiation Oncology, Boston, MA, USA2 Department of Radiation Oncology, St. Louis, MO, USA
(PP311) Differential sensitivity of FancA- and FancD2-deficient cells to complex DNA double strand damage.
Park, Mi-Young1, Seo, Min-Ji1, Park, Hyun-Jin1, Kwon, Hee-Kyung1, Kim, Tae-Hwan2, Lee, Su-Jae3, Lee, Yun-Sil4, Ji, Young-Hoon1, Cho, Chul-Koo1, Choi, Soo-Yong1, Kang, Chang-Mo*,1, 1 Lab. of Radiation Cytogenetics and Epidemiology, Seoul, Seoul, Korea2 Dept. of Veterinary Medicine, Taegu, Seoul, Korea3 Lab. of Radiation Experimental Therapeutics, Seoul, Seoul, Korea4 Lab. of Radiation Effect, Seoul, Seoul, Korea
(PP312) Correlation between conventional dicentric assay and micronuclei assay for biodosimetry in cultured peripheral blood lymphocytes of Korean individuals.
Kataoka, Yasushi*,1, Murley, Jeffrey1, Grdina, David1, 1 Radiation and Cellular Oncology, Chicago, IL, USA
(PP313) Aminothiols can reduce 
-H2AX formation against X-irradiation in human microvascular endothelial cells.
Kato, Takamitsu*,1, Nagasawa, Hatsumi1, Bedoford, Joel, 1 Department of Environmental & Radiological Health Sciences, Ft. Collins, Colorado, USA
(PP314) Interstitial -H2AX foci in metaphase chromosomes after irradiation of wild-type and repair deficient G1 cells.
Kawata, Tetsuya*,1, Shigematsu, Naoyuki2, Uno, Takashi1, Saito, Masayoshi1, Kan'o, Momoe1, Ito, Hisao1, George, Kerry3, Cucinotta, Francis3, 1 Department of Radiology, Chiba-shi, Chiba, Japan2 Department of Radiology, Shinjukuku-ku, Tokyo, Japan3 Radiation Biophysics, Houston, TX, USA
(PP315) Caffeine sensitizes non-dividing human fibroblasts to X-rays or high-LET radiation by inducing high frequency of misrepair.
Kim, Grace*,1, 2, Fiskum, Gary 4, Morgan, William1, 2, 3, 1 Radiation Oncology Research Laboratory, Department of Radiation Oncology, Baltimore, MD, USA2 Molecular and Cell Biology Program, Baltimore, MD, USA4 Department of Anesthesiology, Baltimore, MD, USA3 Marlene and Stewart Greenbaum Center, Baltimore, MD, USA
(PP316) Mitochondrial dysfunction may perpetuate radiation induced genomic instability.
Koturbash, Igor1, Pogribny, Igor2, Stevenson, Sandie1, Kovalchuk, Olga*,1, 1 Department of Biological Sciences, Lethbridge, AB, Canada2 Division of Biochemical Toxicology, Jefferson, AR, USA
(PP317) Chronic low dose radiation exposure profoundly alters DNA and histone methylation in murine thymus.
Baker, Mike*,1, Koturbash, Igor1, Stevenson, Sandie 1, Loree, Jonathan1, Kovalchuk, Olga*,1, 1 Department of Biological Sciences, Lethbridge, AB, Canada
(PP318) Role of epigenetic mechanisms in radiation-induced transgenerational hematopoietic carcinogenesis.
Krueger, Sarah*,1, Joiner, Michael1, Piasentin, Evano1, Wilson, George1, Marples, Brian, 1 Department of Radiation Biology, Detroit, MI, USA
(PP319) Differential G2 checkpoint responses to low-dose radiation.
Laiakis, Evagelia*,1, 2, Morgan, William1, 3, 1 Radiation Oncology Research Laboratory/ Department of Radiation Oncology, Baltimore, Maryland, USA2 Graduate Program in Human Genetics, Baltimore, Maryland, USA3 Greenebaum Cancer Center, Baltimore, Maryland, USA
(PP320) A role for bystander-like factors in maintaining genomic instability.
Shuryak, Igor1, Lange, Christopher*,1, 1 Radiation Oncology/Radiobiology, Brooklyn, NY, USA
(PP321) Cell survival model with DSB repair time regulated by a dose-dependent repair-inhibitory signal.
Lee, Kyung-Jong *,1, Yajima, Hirohiko1, Qin, Jun2, Chen, Benjamin1, Chen, David1, 1 Division of Molecular Radiation Biology, Department of Radiation Oncology, Dallas, TX, USA2 Department of Molecular and Cellular Biology, Houston, TX, USA
(PP322) Implication of interaction between catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and BRCA1.
Leloup, Corinne*,1, Zhu, Aiping1, Hopkins, Kevin1, Lieberman, Howard1, 1 Center for Radiation research, New York, NY, USA
(PP323) Mrad9B-/- ES cells are sensitive to DNA damaging agents.
Lemon, Jennifer*,1, Rollo, C. David2, Boreham, Douglas1, 1 Medical Physics and Applied Radiaions Sciences, Hamilton, ON, Canada2 Biology, Hamilton, ON, Canada
(PP324) A complex dietary supplement dramatically reduces radiation-induced chromosome aberrations and H2AX foci in mice expressing elevated free radical processes.
Balajee, Adayabalam1, Hopkins, Kevin1, Lieberman, Howard*,1, 1 Center for Radiological Research, New York, NY, USA
(PP325) Role of Rad9 in base excision repair.
Krempler, Andrea1, Deckbar, Dorothee1, Tchouandong, Leopoldine1, Walker, Sarah2, Jeggo, Penny2, Lobrich, Markus1, 1 Biophysics Department, Homburg, Saar, Germany2 Genome Damage and Stability Centre, East Sussex, BN, UK
(PP326) ATM-dependent double-strand break repair and checkpoint functions co-operate to maintain chromosomal stability after ionizing irradiation.
Lu, Huimei*,, Shen, Zhiyuan1, 1 Dept. of Molecular Genetics and Microbiology, MSC08-4660, Albuquerque, NM, USA
(PP327) Regulation of homologous recombination by BCCIP.
Malone, Jennifer*,, Lieberman, Rita, Holt, Jeff,
(PP328) The role of BRCA2 in Rad51 localization during breast carcinogenesis.
Wykes, Susan1, Wilson, George1, Joiner, Michael1, Piasentin, Evano1, Wright, Jennifer1, Marples, Brian*,1, 1 Department of Radiation Oncology, Detroit, Michigan, USA
(PP329) Low-dose hyper-radiosensitivity does not result from a failure to recognize DNA double-strand breaks.
Masanori, Someya*,1, Sakata, Koh-ich1, Matsumoto, Yoshihisa2, Yamamoto, Hiroyuki3, Monobe, Manami4, Ikeda, Hideyuki5, Ando, Kouichi6, Hosoi, Yoshio2, Suzuki, Norio2, Hareyama, Masato1, 1 Sapporo Medical University, Sapporo, Japan2 University of Tokyo, Tokyo, Japan3 Sapporo Medical University, Sapporo, Japan4 Tokyo University of Science, Noda, Chiba, Japan5 Sapporo Medical University, Sapporo, Japan6 National Institute of Radiological Sciences, Chiba, Japan
(PP330) The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
McCann, Kelly*,1, Spikacova, Tatiana*,1, Game, John2, Brown, J. Martin1, 1 Department of Radiation Oncology, Stanford, CA, USA2 Life Sciences Division, Berkeley, CA, USA
(PP331) DNA repair response requires chromatin remodeling through histone modification.
Qutob, Sami1, Chauhan, Vinita1, Bellier, Pascale1, Gajda, Greg1, Thansandote, Art1, Yauk, Carole1, Douglas, George1, McNamee, James*,1, 1 Healthy Environments and Consumer Safety Branch, Ottawa, Ontario, Canada
(PP332) Gene expression profiling of a human glioblastoma cell line exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.
McNiel, Elizabeth*,1, Madrill, Nicole1, Griffin, Kelly1, Mickelson, James2, 1 Department of Veterinary Clinical Sciences, Saint Paul, MN, USA2 Department of Veterinary and Biomedical Sciences, Saint Paul, MN, USA
(PP333) Dogs at high risk for transitional cell carcinoma exhibit microsatellite instability in tumors.
Medvedeva, Natalia*,1, Panyutin, Igor1, Neumann, Ronald1, 1 Clinical Center, Department of Nuclear Medicine, Bethesda, MD, USA
(PP334) Phosphorylation of histone H2AX in radiation-induced micronuclei.
Meng, Xiangbing*,1, Shen, Zhiyuan1, 1 Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP335) Knockdown of BCCIP impairs p53-transactivation activity in response to irradiation.
Moore, Stephen*,1, Folkard, Melvyn2, Prise, Kevin2, Kadhim, Munira1, 1 Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom2 Gray Cancer Institute, Northwood, Middlesex, United Kingdom
(PP336) Interindividual variation in genomic instability after targeted charged particle microbeam irradiation.
Morris, Dale*,1, Mitchel, Ron2, Knox, David3, Lavoie, Josée1, Lemon, Jennifer1, Ramdoo, Brendon1, Parchaliuk, Debra3, Boreham, Doug1, 1 Medical Physics, Hamilton, Ontario, Canada2 Chalk River Branch of the Canadian Nuclear Society, Deep River, Ontario, Canada3 Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada
(PP337) Examination of gene expression in trp53 heterozygous mice exposed to low dose radiation using oligo nucleotide cDNA microarrays.
Moskalenko, Oleksandr*,1, Grygoryev, Dmytro1, Zimbrick, John1, 1 Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP338) Changes in transcription of selected DNA repair genes induced by exposure of medaka cells to Cd and ionizing radiation.
Mukherjee, Bipasha*,1, Chen, Benjamin1, Kobayashi, Junya2, Chatterjee, Aloke 3, Chen, David1, Burma, Sandeep1, 1 Dept. of Radiation Oncology, Dallas, TX2 Department of Radiation Biology, Hiroshima, N/A, Japan3 Life Sciences Division, Berkeley, CA
(PP339) DNA-PK phosphorylates hstone H2AX during staurosporine-induced apoptosis of rodent cells.
Murray, David*,1, Mirzayans, Razmik1, 1 Oncology/Experimental Oncology, edmonton, alberta, canada
(PP340) Involvement of ATM and p53 in the rejoining of DNA double-strand breaks at early times after exposure to ionizing radiation.
Nagasawa, Hatsumi*,1, Peng, Yuanlin1, Wilson, Paul1, Lio, Yi-Ching2, Chen, David2, Bedford, Joel1, Little, John3, 1 Environmental and Radiological Health Sciences, Fort Collins, CO, United States2 Department of Radiation Oncology, Dallas, TX, United States3 Center for Radiation Sciences and Environmental Health, Boston, MA, United States
(PP341) Role of homologous recombination in the alpha particle bystander effect for sister chromatid exchanges and chromosomal aberrations.
Nishioka, Takeshi*,1, Yasuda, Motoaki2, Shirato, Hiroki3, 1 Hokkaido University, Sapporo, Japan2 Hokkaido University, Sapporo, Japan3 Hokkaido University, Sapporo, Japan
(PP342) Molecular mechanism behind 'repopulation': A gene expression profiling and pathological in-vitro/in-vivo study of a transplantable mouse tumor cell line.
Noguchi, Miho*,1, 2, 3, Okada, Maki3, Okabe, Atushi3, Ando, Koichi2, Okayasu, Ryuichi3, 1 Graduate School of Science and Technology, Chiba-shi, Chiba-ken, Japan2 Heavy-Ion Radiobiology Research Group, Chiba-shi, Chiba-ken, Japan3 International Space Radiation Laboratory, Chiba-shi, Chiba-ken, Japan
(PP343) Comparison of DNA double strand break repair between irradiated normal human lymphocytes and normal human fibroblasts.
Lehnert, Shirley 1, Sadekova, Svetlana1, Park, Morag1, Hudson, Thomas2, Novak, Jaroslav2, 1 Oncology, Montreal, Quebec, Canada2 Montreal Genome Centre, Montreal, Quebec, Canada
(PP344) Genetic analysis of a human ovarian cell line resistant to cis platinum and ionizing radiation.
Byrne, Shaun1, Bellon, Sophie1, Lomax, Martine1, O'Neill, Peter*,1, 1 DNA Damage Group, Harwell, Oxon, UK
(PP345) Clustered damage: 5,6-dihydrothymine retards base excision repair of an AP site by xrs5 nuclear extracts.
Ohnishi, Takeo*,1, Takahashi, Akihisa1, 1 Dept. Biol., Kashihara, Nara, Japan
(PP346) The DSB-recognizing proteins phospho-Nbs1 and Mre11 co-localize with H2AX in the cell nucleus after heat treatment as well as X-ray irradiation.
Parsons, Jason*,1, Dianov, Grigory1, 1 Radiation and Genome Stability Unit, Didcot, Oxfordshire, UK
(PP347) Processing of 8-oxoguanine within close proximity to a DNA single strand break.
Paunesku, Tatjana*,1, Flores, Ludmila2, Protic, Miroslava3, Cruz, Cecille1, Petrikas, James4, Shivnani, Anand4, Babbo, Angela1, Hlatky, Lynn2, Woloschak, Gayle1, 1 Department of Radiology, Feinberg School of Medicine, Chicago, IL, USA2 Deptartment of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA, USA3 Biology Division, Argonne, IL, USA4 Division of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA
(PP348) In vivo and in vitro activity of mutant PCNA promoter from radiation sensitive wasted mice.
Perkins, Michael*,1, Kumar, K. Sree1, 1 Radiation Casualty Management Team, Bethesda, MD, US
(PP349) In vitro protection against ionizing radiation by the novel radioprotectant ON01210.
Petrikas, James*,1, Shivnani, Anand1, Cruz, Cecille2, Babbo, Angela2, Paunesku, Tatjana2, Woloschak, Gayle2, 1 Northwestern University, Chicago, IL, United States2 Northwestern University, Chicago, IL, United States
(PP350) Differential response to irradiation of wild-type proliferating cell nuclear antigen (PCNA) promoter and mutant PCNA promoter from radiation sensitive wasted (wst) mice.
Pogozelski, Wendy*,1, Hill, Helene2, Blakely, William3, Patel, Janhvi1, Arpaia, Nicholas1, Rummel, Svend1, Senfield, Jeffrey1, Bernard, Matthew1, O'Donnell, Robert4, 1 Department of Chemistry, Geneseo, NY, USA2 Department of Radiology, Newark, NJ, USA3 Department of Applied Cellular Radiobiology, Bethesda, MD, USA4 Department of Biology, Geneseo, NY, USA
(PP351) Radiation-induced increase in the 4977-bp "common deletion" in human mitochondrial DNA in lymphoblast and fibroblast cells.
Sun, Lijie1, Mauldin, Stanley 2, Wallon, Margaretha1, Oliver, Anthony1, DiRienzo, Sharon1, Stamato, Thomas*,1, 1 Lankenau Institute for Medical Research, Wynnewood, PA, USA2 Department of Biology, Philadelphia, PA, USA
(PP352) Purification of a DNA end binding complex with a non-Ku-like mobility shift pattern.
Sudo, Hiroko*,1, Stampfer, Martha1, Barcellos-Hoff, Mary-Helen*,1, Kronenberg, Amy1, 1 Life Science, Berkeley, CA, United States
(PP353) Persistent genomic instability induced by HZE particle radiation in human mammary epithelial cells.
Muto, Masahiro1, Kubo, Eiko 1, Fujimori, Akira1, Nenoi, Mitsuru1, Daino, Kazuhiro1, Matsuda, Yoichi2, Kuroiwa, Asato2, Ukai, Hideki1, Tsuji, HIdeo1, Tatsumi, Kouichi*,1,3, 1 Research Center for Radiation Safety, Chiba, Chiba, JAPAN2 Laboratory of Cytogenetics and Division of Bioscience, Sapporo, Hokkaido, JAPAN3 Institute of Radiation Epidemiology, Tokyo, JAPAN
(PP354) Isolation of human radiation susceptibility gene, hNp95.
Thompson, Larry*,1, Hinz, John1, Salazar, Edmund 1, 1 Biosciences Directorate, Livermore, CA
(PP355) The FANCG Fanconi anemia cancer suppressor protein helps minimize spontaneous and radiation-induced chromosomal rearrangements.
Tinnel, Brent*,1, McGarry, Ronald1, Mendonca, Marc3, Cummings, Oscar2, Chin-Sinex, Helen3, Timmerman, Robert4, 1 Indiana University School of Medicine, Indianapolis, IN, United States3 Indiana University School of Medicine, Indianapolis, IN, United States2 Indiana University School of Medicine, Indianapolis, IN, United States4 UT Southwestern Medical School, Dallas, TX, United States
(PP356) Pulmonary hilar radioablation: An animal model of radiotoxicity.
Turner, Emily*,1, Dovichi, Norman1, 1 Department of Chemistry, Seattle, WA, USA
(PP357) Ultrasensitive analysis of protein expression in single Deinococcus radiodurans tetrads.
Uematsu, Naoya*,1, Yajima, Hirohiko*,1, Chen, Benjamin1, Chen, David1, 1 Division of Molecular Radiation Biology, Department of Dadiation Oncology, Dallas, TX, US
(PP358) Live cell imaging of DNA-PK activation and localization at DSB sites induced by microbeam-laser irradiation.
Wang, Ya*,1, Hu, Baocheng1, 2, Liu, Shuang2, Wang, Xiang1, Rowe, Peter 3, Huang, Cuifen 2, 1 Radiation Oncology, Philadelphia, PA, USA2 Molecular Biology, Beijing, China, China3 Periodontics, San Antonio, TX, USA
(PP359) A new role of MEPE/OF45 as a co-factor of CHK1 in DNA damage response.
Wang, Xiang*,1, Wang, Ya1, 1 Dept. Radiation Oncology, Philadelphia, PA, USA
(PP360) Hus1 protecting mammalian cells from ionizing radiation induced killing is not through affecting non-homologous end-joining.
Wang, Hongyan*,1, Wang, Xiang1, Wang, Ya1, 1 Radiation Oncology, Philadelphia, PA, USA
(PP361) High-energy particles inhibit non-homologous end-joining but do not inhibit homologous recombination repair.
Lu, Hua-Rui1, Wang, Ya1, 1 Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, philadelphia, PA, USA
(PP362) CHK1 interacts with PARP1 to respond to ionizing radiation-induced DNA damage.
Karimi-Busheri, Feridoun1, Rasouli-Nia, Aghdass1, Allalunis-Turner, Joan1, Weinfeld, Michael*,1, 1 Experimental Oncology, Edmonton, Alberta, Canada
(PP363) Cellular evidence supporting human polynucleotide kinase involvement in the non-homologous end joining DNA repair pathway.
Williams, Eli*,1, Bailey, Susan1, Jeggo, Penelope2, Ullrich, Robert1, 1 Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA2 Genome Damage and Stability Centre, Falmer, Brighton, UK
(PP364) Characterization of DNA-PKcs telomeric end-capping function in mammalian cells.
Wilson, Paul*,1, Nagasawa, Hatsumi1, Warner, Christy1, Little, John2, Bedford, Joel1, 1 Environmental and Radiological Health Sciences, Fort Collins, CO, United States2 Center for Radiation Sciences and Environmental Health, Boston, MA, United States
(PP365) Hypersensitivity of cultured fibroblasts from retinoblastoma family members and apparently normal controls: colony formation during continuous low-dose rate irradiation and G2 chromosomal radiosensitivity.
Liu, Jingmei1, Wray, Justin*,1, Shen, Zhiyuan, 1 Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP366) Sumoylation of human Rad52 is critical in its protein stability.
Yajima, Hirohiko*,1, Wang, Junhua1, Chen, David1, Chen, Benjamin1, 1 Division of Molecular Radiation Biology, Department of Radiation Oncology, Dallas, TX, USA
(PP367) Involvement of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in UV damage response.
Yasui, Linda*,1, Chen, Kai2, Jones, T. Patrick1, Caldwell, James1, Guse, Diana1, Kassis, Amin2, 1 Department of Biological Sciences, DeKalb, IL, USA2 Department of Radiology, Boston, MA, USA
(PP368) Using Hoechst 33342 to target radioactivity to the cell nucleus.
Yu, Ying*,1, Banath, Judit1, MacPhail, Susan1, Olive, Peggy 1, 1 Medical Biophysics Dept., Vancouver, BC, Canada
(PP369) Background expression of phosphorylated histone H2AX in tumor cells in relation to DNA double strand breaks and karyotypic complexity.
Zhang, Ying*,1, Lim, Chang1, Williams, Eli1, Zhou, Junqing1, Zhang, Qinming1, Fox, Michael1, Bailey, Susan 1, Liber, Howard1, 1 Department of Environmental and Radiological Science, Ft. Collins, CO, USA
(PP370) NBS1 knockdown increases telomere association and radiation mutagenesis in human cells.
Zhou, Junqing *,1, Zhang, Ying 1, Zhang, Qinming 1, Lim , Chaung 1, Liber, Howard1, 1 Department of Enviromental and Radiological Health Sciences, Fort Collins, CO, USA
(PP371) Rad54 knockdown enhances radiation-induced cell killing and mutation in human cells.