Cell and Tissue Signaling

Albanese, Joseph ^*,1, Dainiak, Nicholas^{2, 3}, ¹ Center for Emergency Preparedness and Disaster Response, New Haven, CT, USA² Department of Medicine, Bridgeport, CT³ Yale University School of Medicine, New Haven, CT, USA
(PP202) Ionizing radiation (IR)-induced transcriptional and translational up-regulation of TNFRSF6 and TNFSF6 in a human bone marrow stromal cell line: Potential biomarkers for radiation exposure.

Andarawewa, Kumari ^*,1, Erickson, Anna ¹, Chou, William ¹, Bissell , Mina ¹, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer biology, berkeley, CA, USA
(PP203) Ionizing radiation predisposes human mammary epithelial cells to TGF induced epithelial to mesenchymal transition.

Ansari, Ramin^*,1, Gaber, M.Waleed ², Wang, Bin¹, Kiani, Mohammad ¹, ¹ Departments of Mechanical Engineering and Radiation Oncology, Philadelphia, PA, USA² Department of Biomedical Engineering, Memphis, TN, USA
(PP204) Radiation-induced bystander effect in normal brain tissue.

Anzenberg, Vered^*,1, Yang, Hongying¹, Held, Kathryn¹, ¹ Radiation Oncology, Charlestown, MA, USA
(PP205) Bystander effect by medium mediated intercellular communication after x-ray and Fe ion beam irradiation in human keratinocytes.

Milliat, Fabien^{*,1, 2}, François, Agnès^{*,1, 2}, Isoir, Muriel^*,1, Sabourin, Jean-Christophe^*,3, Benderitter, Marc ^*,1, ¹ Laboratory of Radiopatholgy, Fontenay aux Roses, France² UPRES EA2710 Radiosensitivity of tumor and normal tissues, Villejuif, France³ Department of Pathology, Villejuif, France
(PP206) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation.

Blakely, Eleanor ^*,1, Schwarz, Richard¹, Thompson, Al², Bjornstad, Kathleen¹, Chang, Polly^{1, 4}, Rosen, Chris¹, Sudar, Damir¹, Romano, Raquel³, Parvin, Bahram³, ¹ Life Sciences Division, Berkeley, CA, USA² Advanced Light Souce Division, Berkeley, CA, USA⁴ Biosciences Division, Menlo Park, CA, USA³ Computational Research Division, Berkeley, CA
(PP207) X-ray microbeam bystander studies with human mammary epithelial cells and fibroblasts.

Boerma, Marjan^*,1, Kennedy, Richard², Kulkarni, Ashwini¹, Joseph, Jacob³, Wondergem, Jan⁴, Wang, Junru¹, Hauer-Jensen, Martin¹, ¹ Departments of Surgery and Pathology, Little Rock, AR, USA² Loyola University Medical Center, Maywood, IL, USA³ Cardiology Section, West Roxbury, MA, USA⁴ Leiden University Medical Center, Leiden, NL, The Netherlands
(PP208) Interactions between mast cells and the endothelin system in radiation-induced heart disease.

Burrell, Cheryl^*,1, Ortloff, Leticia², Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, California, U.S.A.² Radiobioloy Program - Radiation Medicine, Loma Linda, California, U.S.A.³ Research, Loma Linda, California, U.S.A.
(PP209) The role of TGF-beta 1 as a result of repeated subculturing and radiation in FRTL-5 cells.

Cai, Xu Wei^*,1, Fu, Xiao Long¹, ¹ Fudan University Cancer Hospital, Shanghai, China
(PP210) Inhibiting the effects of TGF-1 on increasing collagen formation in fibroblast: the application of replication-defective adenovirus containing radio-inducible Egr-1 promoter and smad7 cDNA under ionizing radiation.

Wang, Rong^{1, 2}, Coderre, Jeffrey^*,1, ¹ Department of Nuclear Science and Engineering, Cambridge, MA, USA² Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA
(PP211) A bystander effect in alpha-particle irradiations of human prostate tumor cells.

Collins-Underwood, J. Racquel^{*,1, 2}, Zhao, Weiling¹, Kooshki, Mitra¹, Robbins, Michael¹, ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC, USA² Department of Cancer Biology, Winston-Salem, NC
(PP212) Role of NADPH oxidase in radiation-induced brain injury.

Cook, John^*,1, Chuang, Yao-Yu¹, Coffin, Deborah¹, DeGraff, William¹, Zhao, Shuping¹, Yan, Hailing¹, Cherukuri, Murali¹, Mitchell, James¹, ¹ Radiation Biology Branch, Bethesda, MD, USA
(PP213) Comparison of gene regulation by nitroxides, hydrogen peroxide, t-butylhydroperoxide, and menadione using microarray time analysis.

Storck, Christopher¹, Vemuri, Srinath¹, Leeper, Dennis, Coss, Ronald^*,1, ¹ Department of Radiation Oncology, Philadelphia, PA, USA
(PP214) The phosphorylated state of Hsp27 in human melanoma cells following thermal therapy.

Crosby, Meredith ^{*,1, 2}, Jacobberger, James¹, Macklis, Roger ³, Almasan, Alexandru^{2, 3}, ¹ Department of Environmental Health Sciences, Cleveland, OH, USA² Department of Cancer Biology, Cleveland, OH, USA³ Department of Radiation Oncology, Cleveland, OH, USA
(PP215) E2F4/p130 complexes serve as critical regulators of the ionizing radiation-induced G2 cell cycle arrest.

Fisher, Carolyn^*,1, Goswami, Prahbat¹, ¹ Free Radical and Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA, USA
(PP216) Increased radioresistance and G2 delay in manganese superoxide dismutase overexpressing human pancreatic cancer cells.

Freyer, James^*,1, Albertini, Rebecca¹, Guerra, Anabel¹, ¹ Bioscience Division, Los Alamos, NM, USA
(PP217) A new model of the tumor microenvironment.

Glazer, Peter^*,1, Bindra, Ranjit¹, ¹ Department of Therapeutic Radiology, New Haven, CT, USA
(PP218) Dysregulation of DNA repair genes in hypoxia.

Greenberger, Joel^*,1, Zhang, Xichen¹, Hricisak, Lauren¹, Epperly, Michael¹, ¹ Radiation Oncology/Medicine, Pittsburgh, PA, USA
(PP219) Absence of the Smad3 gene product increases radiation resistance of bone marrow stromal cells.

Howe, Orla^*,1, White, Christine¹, McClean, Brendan², Lyng, Fiona¹, ¹ Radiation and Environmental Science Centre, Focas Institute, Dublin, Dublin, Ireland²
(PP220) Correlation of intrinsic radiosensitivity with bystander factor production.

Jackson, Isabel^*,1, Batinic-Haberle, Ines¹, Sonveaux, Pierre¹, Vujaskovic, Zeljko¹, ¹ Duke University Medical Center, Durham, NC, United States
(PP221) Hypoxia induced production of ROS by macrophages is associated with TGF-activation.

Johnke, Roberta^*,1, Smith, Elizabeth¹, Kovacs, Charles¹, Evans, Mark¹, Cariveau, Mickael¹, Allison, Ron¹, ¹ Department of Radiation Oncology, Greenville, NC, USA
(PP222) Radioprotection of the murine gastrointestine by IL-1 involves downregulation of apoptotic caspases.

Balfour, Eric², Singh, Anu², Jolly, Puneet^*,1, Velana, Alfredo¹, Jung, Mira¹, Gagnon, Gregory^1,2, ² Georgetown University Hospital, Washington, DC, United States¹ Georgetown University School of Medicine, Washington, DC, United States
(PP223) In vitro comparison of CyberKnife® stereotactic radiosurgery and standard external-beam radiotherapy.

Kadhim, Munira^*,1, Kelly, James¹, Moor, Stephen¹, Smyth, Sharon¹, Goodwin, Edwin², ¹ Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK² Biosciences Division, Los Alamos, New Mexico, USA
(PP224) Comparison of initial and long term damage in irradiated and bystander populations.

Kassis, Amin^*,1, Kishikawa, Hiroko¹, Wang, Ketai¹, Adelstein, S. James¹, ¹ Department of Radiology, Boston, MA
(PP225) Inhibitory (¹²⁵I) and stimulatory (¹²³I) bystander effects produced by radiolabeled tumor cells: in vitro and in vivo studies.

Khodarev, Nikolai^*,1, Labay, Edwardine¹, Darga, Thomas, Beckett, Michael¹, Mauceri, Helena ¹, Halpern, Arielle¹, Bickenbach, Kai ², Veerapong, Jula², Schmidt, P. Henry², Bernard, Roizman³, Weichselbaum, Ralph¹, ¹ Department of Radiation and Cellular Oncology, Chicago, IL, USA² Department of Surgery, Chicago, IL, USA³ Marjorie B. Kovler Viral Oncology Laboratories, Chicago, IL, USA
(PP226) Stat1 dependent pathway as a mediator of tumor response to ionizing radiation and integrator of ionizing radiation and interferon induced pathways.

Kim, Kwanghee^*,1, Iwamoto, Kei¹, McBride, William¹, ¹ Radiation Oncology, Los Angeles, CA, U.S.A.
(PP227) Proteasomal subunit composition of U87 cells is altered by irradiation.

Kirshner, Julia^*,1, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer Biology/Life Sciences, Berkeley, CA
(PP228) TGF1 signaling mediates ATM and its downstream target activation in response to ionizing radiation.

Bi, Meixia¹, Naczki, Christine ¹, Fels, Diane ¹, Koritzinsky, Marianne ², Wouters, Bradly², Koumenis, Constantinos^*,1, ¹ Radiation Oncology, WInston-Salem, NC, USA² Radiotherapy, Maastricht, 6200, Netherlands
(PP229) An ER stress-regulated translational control program confers hypoxia tolerance and promotes tumor growth.

Guo, Chang ^*,1, Brautigan, David², Larner, James^*,1, ¹ Dept. of Radiation Oncology, Charlottesville, VA, USA² Center for Cell Signaling, Charlottesville, VA, USA
(PP230) IR inhibits centrosome separation through Nek2 and PP1.

Kwon, Seok¹, Song, Jae¹, Lee, Yong^*,1, ¹ Department of Surgery, Pittsburgh, PA, USA
(PP231) HIF-1 phosphorylation and its role in the interaction with pVHL.

Lee, Yoon-JIn^*,1, Kim, Dae-Yong¹, Chung, Da Yeon ¹, Bae, Sang-Woo¹, Lee, Su-Jae², Lee, Dae-Hoon¹, Jhon, Gil-Ja³, Lee, Yun-Sil¹, ¹ Laboratory of Radiation Effect, Seoul, Gongneugdong, Korea² Laboratory of Experimental Radiation Therapeutics, Seoul, Gongneugdong, Kores³ Division of Molecular Life Science, Seoul, Daehundong, Korea
(PP232) Enhanced radiosensitization by oleamide in p53 mutant cells.

Seo, Haeng Ran¹, Lee, Dae-Hoon ¹, Bae, Sangwoo¹, Soh, Jae-Won ², Lee, Yun-Sil ¹, ¹ Laboratory of Radiation Effect, Seoul, Nowon-Gu, Korea² Laboratory of Signal Transduction, Incheon, Nam-Gu, Korea
(PP233) Cyclin G1 dacilitates radiation-induced G2-M transition and cell death through transcriptional activation of Cyclin B1.

Giedzinski, Erich¹, Baure, Jennifer¹, Rola, Radoslaw², Fike, John^{1, 2}, Limoli, Charles^*,1, ¹ Radiation Oncology, San Francisco, CA² Neurological Surgery, San Francisco, CA
(PP234) Modifying the radioresponse of neural precursor cells through changes in oxidative stress.

Liu, Zhengfeng^*,1, Prestwich, William¹, Byun, Soo Hyun¹, Mothersill, Carmel¹, McNeill, Fiona¹, Seymour, Collin¹, ¹ Medical Physics and Applied Radiation Sciences, Hamilton, Ontario, Canada
(PP235) The study of low-dose accelerator based neutrons for bystander effects.

Gupta, Damodar ¹, Thakkar, Vipul ², Almasan, Alex³, Macklis, Roger⁴, ¹ Cancer Biology and Radiation Oncology, Cleveland, Ohio, USA² Radaition Oncology, Cleveland, Ohio, USA³ Cancer Biology, Cleveland, Ohio, USA⁴ Radiation Oncology, Cleveland, Ohio, USA
(PP236) Increased expression of CD20 and associated transcription factors by low dose radiation.

Mukherjee, Abhik¹, Martin, Stewart^*,1, ¹ University of Nottingham, Dept of Clinical Oncology, Nottingham, Notts, UK
(PP237) Targeting the thioredoxin system with AW464: hypoxic cytotoxicity, antiangiogenic activity and chemo-/radiosensitisation.

Maslowski, Amy^*,1, Ford, John¹, Braby, Lesley¹, ¹ Nuclear Engineering, College Station, TX, USA
(PP238) Low dose radiation interactions with the TGF- pathway through ECM components.

Meyer, Joshua^*,1, Fitzgerald, T², Altieri, Dario¹, ¹ Department of Cancer Biology, Worcester, MA, USA² Department of Radiation Oncology, Worcester, MA, USA
(PP239) Irradiation upregulates EGFR and survivin in non small cell lung cancer cells.

Mohiuddin, Majid^*,1, Held, Kathryn¹, ¹ Radiation Oncology, Boston, MA, USA
(PP240) Bystander effect on p53 wild-type and mutant colon cancer cell lines at low radiation doses.

D'Cruz, Genevieve^{1, 2}, Gius, David ^{1, 4}, Morgan, William^{1, 2, 3}, ¹ Molecular and Cell Biology Graduate Program, Baltimore, Maryland, USA² Department of Radiation Oncology, Baltimore, Maryland, USA⁴ Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA³ Marlene and Stewart Greenbaum Cancer Center, Baltimore, Maryland, USA
(PP241) Role of molecular chaperone Bag-3/ CAIR-1 in the regulation of Akt and its related proteins following irradiation.

Natarajan, Mohan ^*,1, Mohan, Sumathy², Gibbons, Catherine³, Kadhim, Munira⁴, ¹ Department of Radiation Oncology, San Antonio, Texas, USA² Department of Pathology, Saqn Antonio, Texas, USA³ Environmental Toxicology Graduate Program, Riverside, CA, USA⁴ Radiation and Genomic Stability Unit, Didcot, Oxfordshire, UK
(PP242) Soluble factor mediated bystander response from irradiated human smooth muscle cells to unirradiated endothelium.

O'Dowd, Colm ^*,1, Mothersill, Carmel², Cairns, Micheal³, Austin, Brian⁴, Murphy, James¹, ¹ Radiation and Environmental Science Centre, Dublin, Ireland, Ireland.² School of Medical Physics and Applied Radiation Science, Hamilton, Ontario, Canada.³ Gene Regulation Group, Galway, Ireland, Ireland⁴ School of Life Sciences, Edinburgh, Scotland, UK
(PP243) An investigation of altered cellular response of the epithelioma papillosum cyprinii (EPC) cell line to media from irradiated tissue of rainbow trout (Oncorhynchus mykiss).

Oancea, Marcela^{*,1, 2}, Singhi, Aatur Singhi³, Chumakov, Peter ³, Gudkov, Andrei ³, Almasan, Alex ^{2, 4}, ¹ Department of Chemistry, Cleveland, OH, USA² Department of Cancer Biology, Cleveland, OH, USA³ Department of Molecular Genetics, Cleveland, OH, USA⁴ Department of Radiation Oncology, Cleveland, OH, USA
(PP244) The role of puma, a BH3-only protein, in radiation induced apoptosis.

Oh, Haejin^*,1, Seong, Jinsil¹, An, Jeunghee¹, Kim, Wonwoo¹, ¹ Radiation Oncology, Brain Korea 21 project for Medical Sciences, Seoul, Korea, Korea, south
(PP245) Proteomic analysis for regulation of radiation-induced apoptosis in murine tumors.

Okabe, Atsushi^{1, 2}, Takakura, Kaoru², Okayasu, Ryuichi¹, ¹ International Space Radiation Laboratory, Chiba, Chiba, Japan² Division of Natural Sciences, Mitaka, Tokyo, Japan
(PP246) The autophosphorylation of DNA-PKcs in irradiated human cells.

Pandey, Badri^{*,1, 2}, Gordon, Donna³, de Toledo, Sonia¹, Pain, Debkumar³, Azzam, Edouard¹, ¹ Department of Radiology, Newark, NJ, USA² Radiation Biology and Health Sciences Division, Mumbai, MH, India³ Department of Pharmacology and Physiology, Newark, NJ, USA
(PP247) Low and high dose ionizing radiation differentially modulate mitochondrial function in normal human cells and their progeny.

Pandya, Pinal^*,1, Bianski, Brandon², Ortloff, Leticia², Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, CA, USA² Radiobiology Program-Radiation Medicine, Loma Linda, CA, USA³ Research, Loma Linda, CA, USA
(PP248) Radiation-induced alteration of protein kinase C expression in thyroid follicular cells.

Perez-Nunez, Delia^*,1, Ford, John ¹, Braby, Leslie¹, ¹ NUCLEAR ENGINEERING, COLLEGE STATION, TEXAS, USA
(PP249) Effects in PKcs suppressed AG 1522 cells.

Plesca, Dragos^{*,1, 2}, Mazumder, Suparna¹, Almasan, Alex^{1, 2, 3}, ¹ Department of Cancer Biology, Cleveland, OH, USA² School of Biomedical Sciences, Kent, OH, USA³ Department of Radiation Oncology, Cleveland, OH
(PP250) The interaction of the proteolytic fragment of Cyclin E with Ku70 enhances apoptosis by inhibiting DNA repair.

Portess, Daniel ^*,1, Hill, Mark¹, Bauer, Georg², O'Neill, Peter¹, ¹ Radiation and Genome Stability Unit, Didcot, Oxfordshire, United Kingdom² Abteilung Virologie, Freiburg, Breisgau, Germany
(PP251) Radiation induced signalling leads to apoptotic response in transformed cells: involvement of cytokines and ROS.

Qutob, Sami^*,1, Lachapelle, Sylvie², Thorleifson, Erika¹, Segura, Tamika², Mullins, Dana², Prud'homme-Lalonde, Louise, Wilkinson, Diana², ¹ Consumer and Clinical Radiation Protection Bureau, Ottawa, Ontario, Canada² Radiological Analysis and Defence, Ottawa, Ontario, Canada
(PP252) Identification of radiation responsive biomarkers using a rotary bioreactor to simulate an in vivo environment.

Aguilera, Joe³, Chou, David², Milligan, Jamie², Zhang, Lingxiao³, Lee, Guk Haeng⁵, Yoo, Hyung Jun⁴, Pardo, Francisco^2,3, Rajni, Sethi^*,1, ³ Moores Cancer Center, San Diego, CA, USA² Department of Radiation, San Diego, CA, USA⁵ Department of Otolaryngology, Korea, South Korea⁴ Department of Radiation Oncology, Seoul, South Korea¹ School of Medicine, San Diego, CA, USA
(PP253) Cyclin E modulates radiation sensitivity by altering the function of cell cycle checkpoints and DNA repair in glioblastoma cells.

Rithidech, K. Noy^*,1, Honikel, Louise¹, Rieger, Robert², Xie, Weiping², Fischer, Thomas², Simon, Sanford¹, ¹ Pathology, Stony Brook, NY, USA² Proteomics Center, Stony Brook, NY
(PP254) Analysis of protein expression profiles in blood plasma of mice acutely exposed whole body to ionizing radiation.

Rola, Radoslaw^*,1, Fike, John^{1, 2}, Fishman, Kelly¹, Limoli, Charles², ¹ Dept. of Neurosurgery, San Francisco, CA, USA² Department of Radiation Oncology, San Francisco, CA, USA
(PP255) Persistent oxidative stress impairs hippocampal neurogenesis and increases sensitivity of neuronal precursor cells to radiation.

Sanchez, Martha^*,1, Ortloff, Leticia ², Green, Lora^{1, 2, 3}, ¹ Department of Physiology & Pharmacology, Loma Linda, CA, USA² Radiobiology Program, Loma Linda, CA, USA³ Research, Loma Linda, CA, USA
(PP256) Effects of low dose radiation exposure on glutamate transporter expression and neurotoxicity.

Santi, Stacey^{*,1, 2}, Lee, Hoyun ^{1, 2}, ¹ University of Ottawa, Ottawa, Ontario, Canada² Northeastern Ontario Regional Cancer Centre (NEORCC), Sudbury, Ontario, Canada
(PP257) The Akt/PKB survival pathway: a role for isoform specificity in breast cancer.

Segura, Tamika^*,1, Prud'homme-Lalonde, Louise¹, Lachapelle, Sylvie¹, Mullins, Dana¹, Qutob, Sami², Thorleifson, Erika², Lemyre, Louise³, Wilkinson, Diana¹, ¹ Radiological Analysis & Defence;, Ottawa, Ontario, Canada² Consumer and Clinical Radiation Protection Bureau;, Ottawa, Ontario, Canada³ Institute of Population Health;, Ottawa, Ontario, Canada
(PP258) Biomarkers of radiation exposure and stress based on individual responsiveness.

Semenenko, Vladimir^*,1, Dong, Shaozhong¹, Fan, Ming¹, Ahmed, Kazi¹, Li, Jian Jian ¹, ¹ Divisioin of Moledcular Radiobiology, West Lafayette, Indiana, USA
(PP259) NF-kappaB mediated signaling network in the radioresistance of human breast cancer cells.

Seong, Jinsil^*,1, An, Jeunghee¹, Oh, Haejin¹, ¹ Radiation Oncology, Brain Korea 21 project for Medical Sciences, Seoul, Korea, Korea, south
(PP260) Regulation of radiation-induced apoptosis in murine tissues; proteomic analysis.

Serra, Virginia^*,1, Ortloff, Leticia², Jobe, Marlene², Pandya, Pinal¹, Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, Ca, USA² Radiobiology Program-Radiation Medicine, Loma Linda, Ca, USA³ Research, Loma Linda, CA, USA
(PP261) Radioprotective effects of a super oxide dismutase mimetic on V79-4 micronucleus formation and survival.

Shareef , Mohammed^*,1, Ahmed, Mansoor¹, ¹ Radiation Medicine, Lexington, Kentucky, USA
(PP262) Novel mechanism of regulation of TGF- signaling pathway as a function of oxygen concentration and ionizing radiation exposure of pancreatic carcinoma cells.

Fan, Feiyue¹, Yue, Jingyin¹, Liu, Zheng¹, Zhao, Minghui¹, Zhan, Qimin¹, Shen, Zhiyuan², ¹ Radiation Biology, Tianjin, TJ, China² Molecular Genetics & Microbiology, Albuquerque, NM, USA
(PP263) Function and regulation of ATF3 expression induced by ionizing radiation.

Sitko, John^*,1, McBride, William¹, ¹ Radiation Oncology, Los Angeles, CA, USA
(PP264) Suppressors of cytokine signaling as modulators of radiation response.

Sokolov, Mykyta^*,1, Smirnova, Nataliya², Camerini-Otero, Daniel², Panyutin, Igor¹, Neumann, Ronald¹, ¹ Department of Nuclear Medicine, Bethesda, MD, US² Genetics and Biochemistry Branch and Laboratory of Cellular and Developmental Biology, Bethesda, MD, US
(PP265) Genome-wide changes in gene expression in primary human fibroblasts in response to I-125-induced DNA damage.

Springer, David^*,1, Ahram, Mamoun¹, Kathmann, Loel¹, Miller, John², ¹ Biological Sciences Division, Richland, WA, USA² Computer Science, Richland, WA, USA
(PP266) Protein changes in media conditioned by irradiated CHO cells.

Story, Michael^*,1, Ang, Kian², Ramdas, Latha³, Giri, Uma³, Ashorm, Cheryl ³, Stivers, David⁴, Coombes, Kevin⁴, El-Naggar, Adel⁵, ¹ Molecular Radiation Biology, Dallas, TX, USA² Radiation Oncology, Houston, TX, USA³ Experimental Radiation Oncology, Houston, TX, USA⁴ Biostatistics and Applied Mathematics, Houston, TX, USA⁵ Pathology, Houston, TX, USA
(PP267) Determining a molecular signature for metastasis from the primary tumors of patients with head and neck squamous cell carcinoma.

Sturla, Lisa-Marie^*,1, Amorino, George¹, Alexander, Michael¹, Mikkelsen, Ross¹, Valerie, Kristoffer¹, Schmidt-Ullrich, Rupert¹, ¹ Radiation Oncology, Richmond, VA, USA
(PP268) Requirement of Tyr992 and Tyr1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2.

Sun, Yingli^*,1, Price, Brendan¹, ¹ Radiation Oncology, Boston, MA, USA
(PP269) Tip60 Histone Acetyltransferase regulates the acetyaltion and activation of ATM following DNA damage.

Yang, Hyun Sook¹, Lee, Seung Bum¹, Um, Hong-Duck^*,1, ¹ Laboratory of Radiation Tumor Physiology, Seoul, Korea, Korea
(PP270) JNK-dependent ROS production in mitochondria: its role in gamma-ray-induced cell death.

Wang, Yong^*,1, Schulte, Bradley¹, Zhou, Daohong¹, ¹ Department of Pathology and Lab Medicine, Charleston, SC, USA
(PP271) Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Wang, Tao ^{*,1, 2, 4}, Languino, Lucia^{2, 3, 4}, FitzGerald, Thomas^{1, 4}, ¹ Radiation Oncology, Worcester, MA, USA² Cancer Biology, Worcester, MA, USA⁴ Cancer Center, Worcester, MA, USA³ Cell Biology, Worcester, MA, USA
(PP272) Insulin-like growth factor type I receptor (IGF-IR) mediates radioresistance of DU-145 and PC3 human prostate cancer cells during ionizing radiation.

Williams, Dustin¹, Pond, Chris¹, Leachman, Sancy², Warters, Raymond^*,1, ¹ Department of Radiation Oncology, Salt Lake City, UT, USA² Department of Dermatology, Salt Lake City, UT, USA
(PP273) Protein phosphorylation in irradiated human cells.

Weidhaas, Joanne^*,1, Eisenmann, David², ¹ Therapeutic Radiology, New Haven, CT²
(PP274) A C. elegans model of EGFR-mediated treatment resistance to cytotoxic therapy.

Williams, Jacqueline^*,1, Hernady, Eric¹, Johnston, Carl², Reed, Christina², Finkelstein, Jacob², ¹ Radiation Oncology, Rochester, NY, USA² Pediatrics/Neonatology, Rochester, NY, USA
(PP275) An investigation into the relationship between IL-1, IL-1, MCP-1, and radiation late effects in the lung.

Worgul, Basil^*,1, Kleiman, Norman², David, Janice¹, ¹ Eye Radiation & Environmental Reseach, Dept. Ophthalmology, New York, NY, US² Environmental Health Sciences, New York, NY, US
(PP276) A positive and negative bystander effect influences cataractogenesis in lenses exposed to low doses of x-rays.

Natarajan, Mohan ¹, Nallathamby, Prakash², Xu, Nancy², ¹ Department of Radiation Oncology, San Antonio, Texas, USA² Department of Chemistry and Biochemistry, Norfolk, VA, USA
(PP277) Molecular imaging of TNF-a trafficking from irradiated to un-irradiated cells using silver (Ag) nanoprobes.

Yang, Hongying^*,1, Anzenberg, Vered¹, Held, Kathryn¹, ¹ Department of Radiation Oncology, Boston, MA, USA
(PP278) Comparisons of effects of different charged particles in directly irradiated and bystander normal human fibroblasts.

Yu, Lei^*,1, Domann, Frederick¹, ¹ Free Radical & Radiation Biology, Iowa City, IA, USA
(PP279) GPx-1 inhibits UVA induced AP2 expression in HaCaT cells.

Yu, Yongjia ^*,1, Gao, Yuanyuan¹, Cornforth, Michael¹, Morrill, Steven¹, Gao, Junling², Wu, Ping², ¹ Dept. of Radiation Oncology/Biology Division, Galveston, Texas, USA² Dept. of Neuroscience and Cell Biology, Galveston, Texas, USA
(PP280) Differentiation of grafted human neural stem cells in irradiated rat brain.

Zhao, Weiling^*,1, Kooshki, Mitra¹, Payne, Valerie¹, Robbins, Mike ¹, ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC, USA
(PP281) Transthyretin, a cellular defense gene expressed in traumatic brain injury and Alzheimer′s disease, is upregulated 6 months after brain irradiation.