Mutagenesis/Clastogenesis/Carcinogenesis

Bacher, Jeff^*,1, Halberg, Richard¹, Megid, Wael¹, Kent, Marijo¹, Prolla, Tom², ¹ Genetic Analysis, Madison, WI, USA² Genetics-Biotechnology Center, Madison, WI, USA
(PP056) A novel biodosimetry method for measuring radiation-induced genetic damage.

Banath, Judit^*,1, MacPhail, Susan¹, Larrivee, Bruno¹, Olive, Peggy¹, ¹ Medical Biophysics Dept., Vancouver, BC, Canada
(PP057) Multicellular resistance and HPRT mutation in the tumor microenvironment.

Brooks, Antone^*,1, ¹ Environmental Science and Regional Planning, Richland, Washington, USA
(PP058) How bad is a dirty bomb? Cellular and carcinogenic effects of internally deposited radioactive materials.

Bryant, Peter^*,1, Campbell, Elaine¹, Comrie, Muriel¹, ¹ Bute Medical School, St Andrews, Fife, Scotland
(PP059) Radiation-induced chromatid breaks: are they formed by errors in chromatid deconcatenation?

Burns, Fredric^*,1, Zhang, Ronghe¹, Chen, Shuaili¹, Uddin, Ahmed¹, Wu, Feng, ¹ Environmental Medicine, New York, NY, USA
(PP060) Comparison of gene expression in rat skin following comparable doses of electron or 56Fe ion radiation.

Eberle, Richard¹, Loucas, Bradford¹, Cornforth, Michael^*,1, ¹ Radiation Oncology/ Biology Division, Galveston, TX, USA
(PP061) Long-term transmissibility of radiation-induced chromosome aberrations in human fibroblasts.

Elmore, Eugene^*,1, Lao, Xiao-Yan¹, Ko, Micki¹, Kapadia, Rubina¹, Rightnar, Steven², Nelson, Gregory², Redpath, Les ¹, ¹ Radiation Oncology, Irvine, CA, USA² Loma Linda University Proton Therapy Facility, Loma Linda, CA, USA
(PP062) Neoplastic transformation in vitro induced by low doses of 232 MeV protons.

Ross, Carley¹, Keysar, Stephen¹, French, C. Tenley², Fox, Michael^{1, 2, 3}, ¹ Cell and Molecular Biology Program, Fort Collins, CO, USA² Cytomation, GTX, Fort Collins, CO, USA³ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP063) Analysis of CD59 mutants in CHO A_L cells by flow cytometry after gamma radiation or EMS treatment.

Girdhani, Swati^*,1, Ahmed, Mansoor ², Mishra, Kaushala¹, ¹ Radiation Biology and Health Sciences Division, Mumbai, Maharashtra, India² Weis Centre for Research, Danville, PA, U.S.A
(PP064) Enhancement of ionizing radaition effects on MCF-7 breast cancer cell line by curcumin.

Hada, Megumi^{*,1, 2}, Desai, Nirav^{2, 3}, Cucinotta, Francis², Gonda, Steve², Wu, Honglu², ¹ Division of Space Life Science, Houston, TX, USA² Human Adaptation and Countermeasures Office, Houston, TX, USA³ Radiation Biology, Houston, TX, USA
(PP065) M-BAND analysis of chromosome aberrations induced by heavy ion radiations in human epithelia cells.

Hubbard, Karen¹, Pogozelski, Wendy², Steinberg, Mark³, Orlow, Irene⁴, Dermody, James⁵, Hill, Helene⁶, ¹ Department of Biology, New York, NY, US² Dpartment of Chemistry, Geneseo, NY, US³ Department of Chemistry, New York, NY, US⁴ Epidemiology and Biostatistics Department, New York, NY, US⁵ Department of Microbiology and Molecular Genetics, Newark, NJ, US⁶ Department of Radiology, Newark, NJ, US
(PP066) Enumeration of total and deleted mitochondria in DNA from human skin adjacent to melanomas.

Ianzini, Fiorenza ^{*,1, 2, 3}, Domann, Frederick², Kosmacek, Elizabeth³, Mackey, Michael ^{1, 3}, ¹ Department of Pathology, Iowa City, IA, USA² Department of Radiaiton Oncology, Iowa City, IA, USA³ Department of Biomedical Engineering, Iowa City, IA, USA
(PP067) Radiation-induced mitotic catastrophe in human glioblastoma U87MG cells transduced with a dominant negative p53 adenovirus construct.

Kronenberg, Amy^*,1, Gauny, Stacey¹, Connolly, Lanelle², Turker, Mitchell², ¹ Biophysics Department, Berkeley, CA, USA² CROET, Portland, Oregon, USA
(PP068) Impact of the tissue microenvironment on cell killing and autosomal mutagenesis in murine epithelial cells exposed to 1 GeV/amu Fe ions.

LaRue, Susan^*,1, Trncic, Nadira ¹, Holmes, Adam², Vanais, Diane³, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, Colorado, USA² Cell & Molecular Biology Graduate Program, Fort Collins, Colorado, USA³ Radiation Effects Research Foundation, Hiroshima City, Japan, Japan
(PP069) Severe tumor hypoxia induces mutagenesis.

Lenarczyk, Marek ^*,1, Lasater, Sarah¹, Jordan, Robert ², Schwartz, Jeffrey ², Liber, Howard ¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Department of Radiation Oncology, Seattle, WA, USA
(PP070) Persistent genomic instability induced in human lymphoblastoid cells exposed to —rays.

Dudgeon, Crissy ¹, Li, Henghong^*,2, Bulavin, Dmitry ³, Fornace, Albert ¹, ¹ Dept. of Genetics and Complex Diseases, Boston, MA, US² Center for Cancer Research, Bethesda, MD, US³
(PP071) Characterization of -radiation induced tumorigenesis with a humanized-p53 mouse model.

Zhang, Qinming^*,1, Liu, Yunfeng², Zhou, Junqing¹, Zhang, Ying ¹, Liber, Howard^*,1, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Graduate Degree Program in Cell and Molecular Biology, Fort Collins, CO, USA
(PP072) Wild-type p53 has dominant effects over mutant p53 to maintain genomic stability in human lymphoblast cell.

Loucas, Bradford^*,1, Cornforth, Michael¹, ¹ Department of Radiation Oncology, Galveston, TX, USA
(PP073) Are un-rejoined chromosome breaks always the result of an irreparable lesion?

Manti, Lorenzo^*,1, Court, Jonathan², Durante, Marco¹, Grossi, Gianfranco¹, Pugliese, Gabriella¹, Scampoli, Paola¹, Gialanella, Giancarlo¹, ¹ Physical Sciences, Radiation Biophysics Laboratory, Naples, Italy² Cancer Research Wales Laboratory, Velindre Cancer Centre, Cardiff, Wales, United Kingdom
(PP074) Dependence of radiation clastogenicity upon competence for cytokinesis.

Marozik, Pavel^{*,1, 2}, Mosse, Irma², Seymour, Colin³, Mothersill, Carmel³, ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Laboratory of Radiation Genetics, Minsk, Minsk, Belarus³ Science, Hamilton, Ontario, Canada
(PP075) Modification of radiation-induced bystander effect with melanin.

Marozik, Pavel^*,1, Marozik, Mikhail², Melnov, Sergei², ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Human Biology, Minsk, Minsk, Belarus
(PP076) The level of clastogenic factors as marker of mutation pressure in human population.

Murphy, James^*,1, Nugent, Sharon¹, Seymour, Colin², Mothersill, Carmel², ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Medical Physics & Applied Radiation Sciences, Hamilton, Ontario, Canada
(PP077) Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells.

Parker, Sharon^*,1, Tucker, Jennifer², Pore, Nabendu, Nguyen, Vu², Mullins, Mary², Maity, Amit¹, Kao, Gary¹, ¹ Radiation Oncology, Philadelphia, PA, USA² Cell and Developmental Biology, Philiadelphia, PA, USA
(PP078) Rapid detection of the effects of radiation and histone deacetylase inhibitors on Zebrafish embryonic development.

Ramaiah, Lila^*,1, Weil, Michael², Desaintes, Christian³, Ullrich, Robert², ¹ Department of Microbiology, Immunology, & Pathology, Fort Collins, CO, USA² Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA³ Radiobiology Unit, Boeretang, Mol, Belgium
(PP079) Dissecting the role of Prkdc^BALB polymorphisms in radiation-induced mammary cancer.

Elmore, Eugene¹, Lao, Xiao-Yan¹, Kapadia, Rubina¹, Roa, Dante¹, Sehgal, Varun¹, Al-Ghazi, Matthew¹, Redpath, Les ^*,1, ¹ Department of Radiation Oncology, Irvine, CA, USA
(PP080) Neoplastic transformation in vitro by low doses of low-LET radiation delivered at low dose-rate.

Sirisalee, Tonya ^*,1, Ray, F. Andrew¹, Weil, Michael ¹, Bedford, Joel¹, Schimenti, John², Ullrich, Robert¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Biomedical Sciences, Ithaca, NY, USA
(PP081) Using an embryonic stem cell mutagenesis model to identify radiation sensitivity genes.

Steinberg, Mark^*,1, Hill, Helene², Pierre, Zdenka ¹, Liu, Suqing ¹, Hwang, Bor-Jang ¹, Ji, Fang¹, Hubbard, Karen³, Dermody, James⁴, ¹ Department of Chemistry, New York, NY, US² Department of Radiology, Newark, NJ, US³ Department of Biology, New York, NY, US⁴ Department of Microbiology and Molecular Genetics, Newark, NJ
(PP082) Novel UVB-induced mitochondrial deletions in human epithelial cells.

Sutherland, Betsy^*,1, Bennett, Paula ¹, Cuomo, Noelle¹, Yang, Hongying², Held, Kathryn², ¹ Biology Department, Upton, NY, US² Department of Radiation Oncology, Boston, MA, US
(PP083) DNA damage clusters in bystander cells.

Suzuki, Masao^*,1, Tsuruoka, Chizuru¹, Yasuda, Nakahiro¹, Okayasu, Ryuichi¹, ¹ International Space Radiation Laboratory, Chiba, Chiba, Japan
(PP084) Bystander cellular effects in normal human fibroblasts irradiated with low-energy carbon ions.

Tsai, Mong-Hsun^{*,1, 3}, Tseng, Jennifer², Chuang, Eric^{1, 3, 4}, ¹ Center for Genomic Medicine, Taipei, Taiwan, Taiwan³ Radiation Oncology Science Program/ Center for Cancer Research, Bethesda, MD, US² Molecular, Cellular and Developmental Biology Department, Ann Arbor, MI, US⁴ Department of Electrical Engineering, Taipei, Taiwan, Taiwan
(PP085) Synergistic effect in presence of 17AAG followed by X—ray radiation exposure in human lymphoblastoid cells.

Ueno, Akiko^{*,1, 2}, Vannais, Diane², Waldren, Charles³, ¹ National Institute of Radiological Sciences, Chiba, Japan, Japan² Environmental & Radiological Health Sciences, Fort Collins, CO, USA³ Radiation Effects Research Foundation (RERF), Hiroshima/Nagasaki, Japan, Japan
(PP086) Mutagenicity of fractionated radiations.

Zhou, Xinfeng^*,1, Chen, Bingzi¹, Yi, Huilan¹, Jiang, Tao¹, Dedon, Peter¹, ¹ Biological Engineering Division, Cambridge, MA, USA
(PP087) Novel methods for quantifying ionizing radiation-induced deoxyribose oxidation in DNA.

Grygoryev, Dmytro¹, Moskalenko, Oleksandr¹, Zimbrick, John^*,1, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP088) DNA damage induced by combined cadmium and radiation exposure in vitro and in cultured medaka fish cells.