PARENT SESSIONExperimental and Clinical Therapeutics
Monday, October 17, 2005 3:00 PM-5:00 PM Exhibit Hall Bai, Aiping*,1, Brown, Stephen2, Meier, G.Patrick3, Zhou, Daohong1, 1 Department of Pathology & Lab Medicine, Charleston, SC2 Department of Medicine, Lexington, KY3 Department of Chemistry, Pullman, WA
(PP089) Prodrug modification increases the antioxidant and radioprotective activity of potassium tricyclo[5.2.1.02,6]-decan-8-yl dithiocarbonate (D609).
Bakken, Nicholas*,1, Evans, Mark2, Kovacs, Charles2, Cariveau, Mickael2, Allison, Ron2, Johnke, Roberta2, 1 Department of Physics, Greenville, NC, USA2 Department of Radiation Oncology, Greenville, NC, USA
(PP090) Differential response of two melanoma cell lines following exposure to the photodynamic therapy drug Photofrin.
Balcer-Kubiczek, Elizabeth*,1, Regine, William 2, Attarpour, Mona 1, Jiang, Jing1, Joiner, Michael3, 1 Radiation Oncology/Radiation Oncology Research Laboratory, Baltimore, MD2 Radiation Oncology, Baltimore, MD3 Karmanos Cancer Institute, Detroit, MI
(PP091) Combination of docetaxel and fractionated low-dose irradiation in cell lines exhibiting low-dose hypersensitivity in vitro.
Baumann, Michael*,1, Hessel, Franziska1, Aue, Kristin1, Krause, Mechthild1, Zips, Daniel1, Doerfler, Annegret1, Eicheler, Wolfgang1, Heider, Karl-Heinz2, 1 Dept. of Radiation Oncology, Dresden, Saxony, Germany2
(PP092) Antibody-guided chemotherapy with bivatuzumab mertansine improves the results of fractionated radiotherapy of human FaDu squamous cell carcinoma in nude mice.
Choudhury, Ananya*,1, 2, Jalali, Farid1, Kiltie, Anne 2, Bristow, Robert *,1, 1 Dept. of Radiation Oncology and Medical Biophysics, Toronto, Ontario, Canada2 Division of Cancer Medicine Research, Leeds, West Yorkshire, UK
(PP093) RAD51: A DNA repair target for increasing the therapeutic potential in the treatment of bladder cancer.
Bai,, Aiping1, Meier,, G. Patrick2, Zhou,, Daohong 1, Brown,, Stephen*,3, 4, 1 Department of Pathology and Laboratory Medicine, Charleston, South Carolina, USA2 Department of Chemistry, Pullman, Washington, USA3 Department of Internal Medicine, Lexington, Kentucky, USA4 Research Service, Lexington, Kentucky, USA
(PP094) Comparison of the protective effects of different potassium tricyclo[5.2.1.02,6]-decan-8-yl dithiocarbonate diastereoisomers against ionizing radiation.
Burd, Randy *,1, Lavorgna, Stephanie 1, Thangasamy, Thilakavathy1, Kong, Xianguo1, Lenaz, Luigi 2, Chawla, Shanta2, Reddy, Guru2, Wachsberger, Phylis 1, Dicker, Adam1, 1 Radiation Oncology, Philadelphia, PA, USA2 Oncology, Irvine, CA, USA
(PP095) Enhancement of radiation response in tumors by the bioreductive agent Apaziquone (EO9, EOquin).
Bussink, Jan*,1, Troost, Esther1, Kaanders, Johannes1, van Eerd, Julliette2, Peters, Johannes1, Rijken, Paul1, Boerman, Otto2, van der Kogel, Albert1, 1 Dept. of Radiation Oncology, Nijmegen, The Netherlands, The Netherlands2 Dept. of Nuclear Medicine, Nijmegen, The Netherlands, The Netherlands
(PP096) Quantification of CAIX by immunohistochemistry, autoradiography and SPECT analysis in three human tumor lines.
Chen, Fang-Hsin*,1, 2, Liu, Wei-Chung 1, Hsieh, Kai-Fong1, Hong, Ji-Hong 2, Chiang, Chi-Shiun1, 1 Department of Atomic Science, Hsinchu, Taiwan(R.O.C.)2 Department of Radiation Oncology, Taoyuan, Taiwan(R.O.C.)
(PP097) Oral consumption of Cordyceps sinensis promotes the recovery of radiation-induced bone marrow and intestinal injuries in mice.
Chen, Miao-fen*,1, Chen, Wen-cheng1, Wu, Chun-te1, Mazzatti, Dawn2, Hu, Yueh-chiang2, Liao, Shuen-kuei1, Keng, Peter2, 1 Radiation Oncology, Taipei, Taiwan, Republic of China2 Radiation Oncology, Rochester, NY, USA
(PP098) Antisense to human peroxiredoxin I enhances radiation sensitivity of lung cancer cells.
Chernikova, Sophia*,1, Peters, Katherine1, Kovacs, Mary1, Brown, J. Martin1, 1 Radiation Oncology, Stanford, CA, USA
(PP099) Mechanism of sensitization of hypoxic cells to cisplatin by tirapazamine.
McDonough, James1, Arguiri, Evguenia2, Solomides, Charalambos2, Cengel, Keith1, Christofidou-Solomidou, Melpo2, 1 University of Pennsylvania, Philadelphia, PA, USA2 Department of Medicine, Philadelphia, PA, USA
(PP100) Curcumin ameliorates radiation-induced pulmonary fibrosis and decreases tumor burden in a C57/Bl6/Lewis lung carcinoma model system.
Storck, Christopher1, Wahl, Miriam2, Leeper, Dennis1, Coss, Ronald*,1, 1 Department of Radiation Oncology, Philadelphia, PA, USA2 Department of Pathology, Durham, NC, USA
(PP101) Acute acidification reduces the heat shock response and sensitizes human melanoma cells grown at low pH to thermal therapy.
Dahle, Jostein*,1, Borrebæk, Jørgen2, Salberg, Gro2, Bruland, Øyvind Sverre3, Olsen, Dag Rune1, Larsen, Roy Hartvig2, 1 Radiation Biology, Oslo, NORWAY, NORWAY2 Research, Oslo, NORWAY, NORWAY3 Clinical Oncology, Oslo, NORWAY, NORWAY
(PP102) Biodistribution of 227Th, 227Th-DOTA and 227Th-DOTA-rituximab in Balb/c mice.
Davis, Mary*,1, Lawrence, Theodore1, 1 Radiation Oncology, Ann Arbor, MI
(PP103) Radiosensitization of hepatic cancers by the combination of gemcitabine and fluorodeoxyuridine.
Busto, Eduardo2, Vallerga, Maria1, Sardi, Mabel Edith3,2, Di Giorgio, Marina1, 2 Radiation Oncology and Otorhinolaringology, Buenos Aires, Argentina1 Autoridad Regulatoria Nuclear, Buenos Aires, Argentina3 Mevaterapia, Buenos Aires, Argentina
(PP104) DNA repair capacity as a predictive radiation sensitivity test. Inferences for clinical practice and radiation protection.
Dynlacht, Joseph*,1, Valluri, Shailaja2, DesRosiers, Colleen1, Greer, Falon1, Caperell-Grant, Andrea3, Mendonca, Marc1, Lopez, Jennifer1, Bigsby, Robert3, 1 Radiation Oncology, Indianapolis, Indiana, United States of America2 Ophthalmology, Indianapolis, Indiana, United States of America3 Obstetrics and Gynecology, Indianapolis, Indiana, United States of America
(PP105) Inhibition of radiation-induced cataractogenesis by estrogen.
Evans, Sydney*,1, Schrlau, Amy1, Chalian, Ara2, Zhang, Paul3, Koch, Cameron1, 1 Radiation Oncology, Philadelphia, Pa., USA2 Otorhinolaryngology, Philadelphia, Pa., USA3 Pathology, Philadelphia, Pa., USA
(PP106) Hypoxia in human skin as measured by EF5 binding.
Fan, G*,1, Atencio, D1, Ho, A1, Green, S1, Formenti, S2, Haffty, B3, Bernstein, J4, Iyengar, P1, Stock, R1, Cesaretti, J1, Rosenstein, B1, 2, 1 Department of Radiation Oncology, New York, NY, USA2 Department of Radiation Oncology, New York, NY, USA3 Department of Therapeutic Radiology, New Haven, CT, USA4 Department of Epidemiology and Biostatistics, New York, NY, USA
(PP107) Genetic predictors of adverse radiotherapy effects in African-American breast cancer patients.
Feng, Felix*,1, Chun, Patrick 1, Davis, Mary1, Lawrence, Theodore 1, Nyati, Mukesh1, 1 Radiation Oncology, Ann Arbor, MI, USA
(PP108) Achievement of prolonged tumor regression in head and neck cancer using gefitinib, gemcitabine, and radiation.
Fenton, Bruce*,1, Paoni, Scott1, 1 Department of Radiation Oncology, Rochester, NY, USA
(PP109) Pathophysiological effects of antibodies to IGF-1R and VEGFR-2 plus fractionated radiation in DU145 prostate carcinoma xenografts.
Freeman, Michael *,1, Sekhar, Konjeti1, Rogers, Buck2, Crooks, Peter3, Xu, Mai2, Moros, Eduardo2, Roti Roti, Joseph2, 1 Vanderbilt University, Nashville, TN, United States2 Washington University School of Medicine, St. Louis, MO, United States3 University of Kentucky, Lexington, KY, United States
(PP110) Development of enhancers of thermal radiosensitization.
Fernainy, Pamela1, Geara, Fady*,2, Itani, Wafika1, Haddadin, Makhluf3, Ghali-Muhtasib, Hala1, 1 Department of Biology, Beirut, Lebanon, Lebanon2 Department of Radiation Oncology, Beirut, Lebanon, Lebanon3 Department of Chemistry, Beirut, Lebanon, Lebanon
(PP111) Molecular mechanisms of the radiosensitizing effects of a quinoxaline dioxide derivative.
Geldof, Albert*,1, Kuipers, Gitta3, Sminia, Peter3, Lafleur, M. Vincent3, Zerp, Shuraila4, Yang, Dajun5, Lippman, Mark5, Slotman, Berend3, Verheij, Marcel3, 1 VU Medical Center, Amsterdam, Netherlands3 VU Medical Center, Amsterdam, Netherlands4 The Netherlands Cancer Inst., Amsterdam, Netherlands5 University of Michigan, Ann Arbor, MI, United States
(PP112) Gossypol, a small molecule inhibitor of Bcl-2, affects radiation sensitivity in human prostate cancer cells.
Gerweck, Leo*,1, Vijayappa, Shashirekha1, 1 Massachusetts General Hospital, Boston, MA, United States
(PP113) Assessing tumor pH as a determinant of the efficacy weak acid and base chemotherapeutics in-vivo.
Greco, Olga*,1, Ireson, Christopher2, Coralli, Claudia2, Dachs, Gabi2, Shima, David3, Steele, Andrew2, Kanthou, Chryso1, 2, Tozer, Gillian1, 2, 1 Tumour Microcirculation Group, Sheffield, South Yorkshire, UK2 Tumour Microcirculation Group, Northwood, Middlesex, UK3 Eyetech Research Center, Woburn, MA, USA
(PP114) Role of VEGF and angiopoietins on tumour response to vascular disrupting agents and radiation.
Griffin, Robert*,1, Williams, Brent1, Park, Heon Joo1, Song, Chang1, 1 Radiation Biology Section, Department of Radiation Oncology, Minneapolis, MN, USA
(PP115) Thermoradiotherapy enhancement with anti-vascular strategy.
Yacoub, Adly1, Dent, Paul1, Hagan, Michael *,1, 1 Radiation Oncology, Richmond, VA, USA
(PP116) Together, active EGFR and EGFR trans-activated by irradiation over-activate PARP depleting NAD+ and increasing cell-killing.
Hamstra, Daniel*,1, 3, Griffin, Laura1, 4, Bhojani, Swaroop1, 4, Ross, Brian2, 3, 4, Rehemtulla, Alnawaz1, 2, 4, 1 Departments of Radiation Oncology, Ann Arbor, MI3 Department of Biochemistry, Ann Arbor, MI4 The Center for Molecular Imaging, Ann Arbor, MI2 Department of Radiology, Ann Arbor, MI
(PP117) Non-invasive real time imaging of the oscillatory pattern of p53 dependent gene activation following chemoradiotherapy.
Debucquoy, Annelies1, Goethals, Laurence1, McBride, William2, Haustermans, Karin*,1, 1 Department of Radiation Oncology and Experimental Therapy, Leuven, Vlaams Brabant, Belgium2 Department of Radiation Oncology, Los Angeles, California, USA
(PP118) The effect of COX-2 inhibition on molecular responses of rectal cancer to preoperative chemoradiation in a Phase II randomized, double-blind, placebo-controlled clinical trial.
Hill, Colin *,1, Dagliyan, Grant1, Kumar, Parvesh1, 1 Dept of Radaition Oncology, Los Angeles, CA, USA
(PP119) Effects of 13-cis-retinoic acid and Interferon with or without radiation on prostate tumor cells and normal human rectal and lung cells.
Hoopes , P. Jack *,1, 2, Yeo, Tet-kin 1, Strawbridge, Rendall1, Sundaram , Sujatha 1, Gladstone , David 2, Paul, Brian 1, 2, Shenberger , Jeffrey 3, Myers , Jeniffer 3, Buckey, Jay 2, O'Hara, Julia2, Hug , Eugne 2, 1 Department of Surgery, Hanover, NH, USA2 Department of Medicine (Radiation Oncology), Hanover, NH, USA3 Department of Pediatrics, Hanover, NH, USA
(PP120) Hyperbaric oxygen improves survival of irradiated CNS astrocytes and neurons.
Hopewell, John*,1, Millar, William2, 1 Department of Clinical Oncology, Oxford, Oxon, UK2 Department of Radiation Oncology, Glasgow, Strathclyde, UK
(PP121) Effects of low dose-rate 90Sr/90Y exposure on the acute moist desquamtion response of pig skin.
Jaal, Jana*,1, Doerr, Wolfgang1, 1 Dept. of Radiotherapy and Radiation Oncology, Dresden, Saxony, Germany
(PP122) Effect of recombinant human keratinocyte growth factor (rHuKGF, Palifermin) on radiation-induced mouse urinary bladder dysfunction.
Kavanagh, Brian*,, Schefter, Tracey1, Gaspar, Laurie1, Zaemisch, Rebekah1, Gravdahl, Daniel1, Raben, David1, Frederick, Barbara1, 1 University of Colorado, Aurora, CO, USA
(PP123) Changes in serum vascular endothelial growth factor (VEGF) levels following stereotactic body radiation therapy (SBRT) to liver and lung tumors.
Khan, Atif*,1, Mehta, Par1, Foutch, Jennifer1, Kirk, Michael1, Chu, Jim 1, Abrams, Ross1, Blazek, Ed1, 1 Department of Radiation Oncology, Chicago, IL, USA
(PP124) Clonogenic survival does not uniformly increase with split time between halves of 2-Gy fractions: implications for IMRT.
Koch, Cameron*,1, Oprysko, Patricia1, 1 Radiation Oncology, Philadelphia, PA
(PP125) Use of 2-nitroimidazole binding to determine the lifetime of hypoxic cells.
Milas, Luka1, Koto, Masashi*,1, Valdecanas, David1, Mason, Kathy1, Hunter, Nancy1, Fan, Zhen2, Fang, Fu-Min1, Ang, Kian3, 1 Experimental Radiation Oncology and Division of Radiation Oncology, Houston, TX, USA2 Experimental Therapeutics, Houston, TX, USA3 Division of Radiation Oncology, Houston, TX, USA
(PP126) C225-induced enhancement of tumor radioresponse: Influence of timing of C225 administration.
Kozin, Sergey*,1, Winkler, Frank1, Tong, Ricky1, Chae, Sung-Suk1, Booth, Michael1, Xu, Lei1, Hicklin, Daniel2, Fukumura, Dai1, di Tomaso, Emmanuelle1, Munn, Lance1, Jain, Rakesh1, 1 Department of Radiation Oncology, Boston, MA, USA2 Department of Immunology, New York, NY, USA
(PP127) Kinetics of vascular normalization by VEGFR2 blockade governs the response of glioma xenografts to radiation.
Krager, Kimberly*,1, Niu, Gang1, Madsen, Mark2, Graham, Michael2, Stevenson, Gail3, Liu, Zhonglin3, Barrett, Harrison3, Domann, Frederick 1, 1 Radiation Oncology, Iowa City, IA, United States2 Department of Radiology, Iowa City, IA, United States3 Department of Radiology, Tucson, AZ, United States
(PP128) Quantitative dosimetry and biodistribution of radionuclide concentrator therapy in ad-NIS transduced head and neck carcinoma.
Krause, Mechthild*,1, Ostermann, Gernot1, Petersen, Cordula1, Harstrick, Andreas2, Yaromina, Ala1, Thames, Howard3, Baumann, Michael1, 1 Dept. of Radiation Oncology, Dresden, Saxony, Germany2 Merck KG aA, Darmstadt, Hessen, Germany3 Dept. of Biomathematics, Houston, Texas, USA
(PP129) Targeting of the EGFR by C225 improves local control of FaDu hSCC by decreased repopulation and increased reoxygenation during fractionated irradiation.
Krishnan, Sunil*,1, Shentu, Shujun1, Schwartz, David1, Puduvalli, Vinay2, 1 MD Anderson Cancer Center, Houston, TX, United States2 MD Anderson Cancer Center, Houston, TX, United States
(PP130) Suberoyl anilide hyroxamic acid (SAHA) sensitizes pancreatic cancer cells to radiation therapy.
Leeper, D.*,1, Linek, J.1, Pollard, M.1, Pocceschi, M.1, Henderson, K.2, Boman, B.2, 1 Radiation Oncology, Philadelphia, PA, USA2 Genetics and Preventive Medicine, Philadelphia, PA, USA
(PP131) Radiation response and stem cell number of crypts of mouse small and large intestine.
Li, Fang *,1, Sovenaux, Pierre 1, Dewhirst, Mark , Li, Chuan, 1 Radiation Oncoloty, Durham, NC, U.S.A
(PP132) A noninvasive approach to image HIF-1a level in tumor response to radiation therapy.
Li, Wang*,1, Yan, Feng1, Xiaorong, Fu1, Xuwei, Cai1, 1 Fudan University, Shanghai, China
(PP133) The in vivo study on adenovirus mediate smad7 gene expression regulated by irradiation via Egr-1 promoter.
Liu, Shanling*,1, 2, Wang, He2, Yang, Zhonghui1, Kon, Takashi1, Zhu, Jiangao3, Cao, Yiting1, Nicchitta, Christopher4, Li, Chuan-Yuan1, 1 Radiation Oncology, Durham, NC, USA2 West China Second University Hospital, Chengdu, Sichuan, P.R.China3 Immunology, Durham, NC, USA4 Cell Biology, Durham, NC, USA
(PP134) Tumor radiation therapy enhanced by use of adenovirus-mediated GRP94/gp96 expression.
Luijk, P.*,1, Novakova-Jiresova, A.2, Steneker, M.N.J.1, Faber, H.2, Meertens, H.1, Kampinga, H.H.2, Coppes, R.P.1, 2, 1 Radiation Oncology, Groningen, Groningen, The Netherlands2 Radiation and Stress Cell Biology, Groningen, Groningen, The Netherlands
(PP135) The relation between structural and functional changes in the rat lung after irradiation.
Luo, Xian*,, Kim, Dong, Crapo, James, Pearlstein, Robert, Slater, James, Gridley, Daila,
(PP136) Differential modification of tumor and normal cell response to radiation by metalloporphyrin antioxidant.
Mendonca, Marc*,1, 2, Chin-Sinex, Helen1, Mead, Laura3, Yoder, Merv3, Ingram, David3, 1 Radiation Oncology / Radiation and Cancer Biology Labs, Indianapolis, IN, USA2 Medical and Molecular Genetics, Indianapolis, IN, USA3 Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, IN, USA
(PP137) Endothelial stem/progenitor cells are X-ray sensitive with limited repair capacity.
Milosevic, Michael*,1, 3, Skliarenko, Julia2, 3, Lunt, Sarah Jane2, 3, Fyles, Anthony1, 3, Hill, Richard2, 3, 1 Radiation Medicine Program, Toronto, ON, Canada3 University of Toronto, Toronto, ON, Canada2 Ontario Cancer Institute, Toronto, ON, Canada
(PP138) Interstitial permeability and elasticity in tumors: Possible biomarkers of response to targeted treatment?
Cotrim, Ana2, Hyodo, Fuminori1, Sowers, Anastasia1, Matsumoto, Ken-Ichiro1, Baum, Bruce2, Krishna, Murali1, Mitchell, James 1, 2 National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA1 National Cancer Institute, Bethesda, Maryland, USA
(PP139) MRI assessment of nitroxide-mediated selective normal tissue radioprotection.
Moeller, Benjamin*,1, Dreher, Matthew2, Rabbani, Zahid3, Schroeder, Thies3, Cao, Yiting1, Dewhirst, Mark1, 2, 3, 1 Department of Pathology, Durham, NC, USA2 Department of Biomedical Engineering, Durham, NC, USA3 Department of Radiation Oncology, Durham, NC, USA
(PP140) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
Cohen, Eric1, Fish, Brian2, Moulder, John*,2, 1 Medicine, Milwaukee, WI, USA2 Radiation Oncology, Milwaukee, WI, USA
(PP141) Angiotensin II type-2 (AT2) receptor blockade in experimental radiation nephropathy.
Sharma, Mukut 1, McCarthy, Ellen1, Sharma, Ram1, Fish, Brian2, Savin, Virginia 1, Cohen, Eric1, Moulder, John*,2, 1 Nephrology Division, Milwaukee, WI, USA2 Department of Radiation Oncology, Milwaukee, WI, USA
(PP142) Ibuprofen prevents the early effects of ionizing radiation on normal glomeruli.
Niu, Gang*,1, Anderson, Richard4, Madsen, Mark2, 3, Graham, Michael 2, 3, Oberley, Larry1, 3, Domann, Frederick 1, 3, 1 Free Radical & Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA4 Viraquest Inc., North Liberty, IA2 Department of Radiology, Iowa City, IA3 Carver College of Medicine & Holden Comprehensive Cancer Center, Iowa City, IA
(PP143) Quantitative and non-invasive radiological imaging of tumor targeted p53 and MnSOD gene transfer and expression with dual expressing adenoviral vectors.
Gibbs, Summer1, O'Hara, Julia*,1, Chen, Bin*,1, Savellano, Mark1, Hoopes, P Jack1, 2, Pogue, Brian1, 1 Thayer School of Engineering, Hanover, NH, USA2 Dept of Surgery, Lebanon, NH, USA
(PP144) Tumor diagnosis or treatment using the prodrug, ALA: cell line dependence of protoporphyrin IX production.
O'Hara, M,*,2, Pollard, M.1, Pocceschi, M.1, Leeper, D.1, 2 Center for Devices and Radiological Health, Rockville, MD, USA1 Radiation Oncology, Philadelphia, PA, USA
(PP145) MIBG plus hyperglycemia sensitizes bone marrow CFU-F but not CFU-C to Cs-137 irradiation in Situ.
Oh, Yoon Kyeong*,1,3, Xu, H.1, Lee, T. B. 1, Choi, C. H. 1,2, 1 Chosun University, Gwangju, South Korea3 Chosun University Medical School, Gwangju, South Korea2 Chosun University Medical School, Gwangju, South Korea
(PP146) Radioresistance mechanisms of chemoresistant leukemic and lung cancer cell lines.
Pajonk, Frank*,1, Riedisser, Anja 2, McBride, William1, Fiebich, Bernd3, 1 Department of Radiation Onoclogy, Los Angeles, CA, USA2 Department of Radiation Oncology, Freiburg, BW, Germany3 Department of Psychiatry, Freiburg, BW, Germany
(PP147) Topically applied green tea extracts to treat radiation-induced skin toxicity - involvement of a caspase-dependent mechanism.
Palayoor, Sanjeewani*,1, Mitchell, James1, DeGraff, William1, Powis, Garth2, Kirkpatrick, Lynn3, Coleman, C.Norman1, 1 National Cancer Institute, Bethesda, MD, USA2 Arizona Cancer Center, Tucson, AZ, USA3
(PP148) Radiosensitivity of prostate carcinoma cells irradiated under normoxic and hypoxic conditions following treatment with HIF inhibitor PX-478.
Cowen, Rachel1, Wind, Natasha1, Telfer, Brian1, Stratford, Ian1, Papadopoulou, Maria*,2, Bloomer, William2, Williams, Kaye1, 1 School of Pharmacy and Pharmaceutical Sciences, Manchester, Greater Manchester, UK2 Department of Radiation Medicine, Evanston, Illinois, USA
(PP149) Exploiting cytochrome p450 reductase-mediated enhancement of NLCQ-1 hypoxic cytotoxicity for use in combination with radiotherapy.
Paquette, Benoit*,1, Baptiste, Catherine 1, Therriault, Hélène 1, Arguin, Guillaume 2, Plouffe, Bianca 3, Lemay, Rosalie1, 1 Department of nuclear medicine and radiobiology, Sherbrooke, Québec, Canada2 Department of pharmacology, Sherbrooke, Québec, Canada3 Department of physiology, service of endocrinology, Sherbrooke, Québec, Canada
(PP150) Irradiation of basement membrane enhances the invasiveness of breast cancer cells.
Park, Heon Joo*,1, Choi, Eun Kytung2, Ji, In-Mi 1, Kim, Eun Jung1, Lee, So Ryung2, WIlliams, Brent 3, Griffin, Robert 3, Ha, Sung Whan4, Lim, Byung Uk1, Song, Chang Won3, 1 Dept of Microbiology, Inchon, South Korea, South Korea2 Dept of Radiation Oncology, Seoul, South Korea, South Korea3 Dept of Therapeutic Radiology-Radiation Oncology, Minneapolis, MN, USA4 Dept of Radiation Oncology, Seoul, South Korea, South Korea
(PP151) Radiation-induced activation of NQO1 potentiates the cytotoxicity of bio-reductive drugs.
Parmar, Kalindi*,1, Vergilio, Jo-Anne2, Clyne, James1, Sackstein, Robert3, Mauch, Peter1, 4, Down, Julian5, 1 Department of Radiation Oncology, Boston, MA, USA2 Department of Pathology, Boston, MA, USA3 Department of Dermatology and Medicine, Boston, MA4 Department of Radiation Oncology, Boston, MA5 Research, Cambridge, MA
(PP152) Primitive hematopoietic stem cells are sequestered in a hypoxic microenvironment within the bone marrow: implications for oxygen-dependent cytotoxic injury.
Pattillo, Christopher *,1, Sari-Sarraf, Farid1, Nallamothu, Ramakrishna2, Moore, Bob2, Wood, George2, Kiani, Mohammad1, 3, 1 Department of Mechanical Engineering, Philadelphia, PA, USA2 Department of Pharmaceutical Science, Memphis, TN, USA3 Department of Radiation Oncology, Philadelphia, PA, USA
(PP153) Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay.
Pena, Louis*,1, Lin, Xinhua1, Glass, John1, Crawford, Janet2, Zamora, Paul3, 1 Medical Department, Upton, NY, USA2 W.M. Keck Biotechnology Laboratory, New Haven, CT, USA3 BioSET Inc., College Park, MD, USA
(PP154) Radiation protection by FGF-2 mimetic, multi-domain peptides.
Pervan, Milena*,1, de Vos, Sven 2, Calimlim, Jeffrey2, Said, Jonathan2, McBride, William1, 1 Radiation Oncology Department, Los Angeles, CA2 Hem/Onc Department, Los Angeles, CA
(PP155) Proteasome inhibitor Bortezomib enhances effectiveness of radioimmunotherapy of diffuse large B-cell lymphoma.
Peschke, Peter*,1, Karger, Christian 1, Scholz, Michael2, Sanchez-Brandelik, Rita1, Huber, Peter1, 3, Debus, Jürgen1, 3, 1 Dept. of Radiotherapy, 69120-Heidelberg, Germany, Germany2 Dept. of Biophysics, Darmstadt, Germany, Germany3 Dept. of Clinical Radiology, Heidelberg, Germany, Germany
(PP156) Radiation-induced myelitis in the spinal cord of rats after single and split doses of photons and carbon ions.
Pickett, Heather*,1, Sandison, George1, Li, Jian Jian1, 1 Molecular Radiobiology Division, West Lafayette, Indiana, USA
(PP157) Effects of radiation and cryotherapy on tumorigenic and non-tumorigenic human prostrate cell lines.
Plastaras, John*,1, Gudonis, Deborah2, Ahmed, Mona1, Cerniglia, George1, Frank, Ian2, Gupta, Anjali1, 1 University of Pennsylvania Hospital, Philadelphia, PA, United States2 University of Pennsylvania Hospital, Philadelphia, PA, United States
(PP158) Validation of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans.
Ponce, Ana*,1, Viglianti, Benjamin1, Yarmolenko, Pavel2, Bally, Marcel3, Woo, Janet3, Dewhirst, Mark2, 1 Dept of Biomedical Engineering, Durham, NC2 Dept of Radiation Oncology, Durham, NC3 BC Cancer Agency, Vancouver, BC
(PP159) Liposomal drug distribution and anti-tumor effect: drug dose painting with hyperthermia using MRI.
Powell, Alaina*,1, Che, Mingxin3, Marples, Brian 2, Joiner, Michael2, Wilson, George 2, 1 Graduate Programs in Cancer Biology, Detroit, MI, United States3 Department of Pathology, Detroit, MI, United States2 Department of Radiation Oncology, Detroit, MI
(PP160) The prevalence of hypoxic markers in prostate tumors.
Quennet, Verena*,1, Walenta, Stefan1, Zips, Daniel2, Yaromina, Ala2, Baumann, Michael 2, Mueller-Klieser, Wolfgang1, 1 Institute of Physiology and Pathophysiology, Mainz, RLP, Germany2 Department of Radiotherapy and Oncology, Medical Faculty, Dresden, RLP, Germany
(PP161) Characterization of the glucose metabolism in xenotransplanted human squamous cell carcinomas.
Rhee, Juong*,1, Gu, Yeun2, Lee, Yong3, 1 Radiation Oncology, Baltimore, MD, U.S.A.2 Graduate School of Helath Science, Suzuca, Mie, Japan3 Surgery, Pittsburgh, PA, U.S.A.
(PP162) Uneven distribution of green fluorescence positive cells within multicell spheroids following adenoviral transduction.
Rhoades, Samuel*,1, 2, Blough, Melissa1, 2, Hevezi, James1, 3, 1 Dept of Radiological Sciences, San Antonio, TX2 Dept of Medical Physics, San Antonio, TX3
(PP163) A pilot study evaluating the prevention of abdominal adhesions via administration of beta radiation from a 90Sr/90Y applicator.
Lehnert, Shirley1, Owusu, Abraham 1, Li, Yongbiao1, Bump, Edward2, Riddoch, Bill2, 1 Oncology/Radiation Oncology, Montréal, Québec, Canada2 Radiopharmaceuticals, Kirkland, Québec, Canada
(PP164) Intra-tumoral delivery of radiolabeled iododeoxyuridine.
Robbins, Mike*,1, Gilliam-Davis, Shea2, Payne, Valerie1, Tommasi, Ellen2, Diz, Debra2, 1 Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC2 Hypertension & Vascular Disease Center, General Surgery, Winston-Salem, NC
(PP165) Whole brain irradiation reduces insulin, leptin and body weight in Fisher 344 rats one year post-treatment: effects of AT1-receptor blockade.
Rockwell, Sara *,1, Liu, Yanfeng1, Gilmore-Hebert, Maureen1, Tomasz, Maria2, 1 Department of Therapeutic Radiology, New Haven, CT2 Department of Chemistry, New York, NY
(PP166) Response of aerobic and hypoxic Fanconi Anemia cells to mitomycin c and decarbamoyl mitomycin c.
Xu, Mai1, Wu, M2, Crooks, Peter3, Freeman, Michael4, Roti Roti, Joseph*,1, 1 Radiation and Cancer Biology Division, St. Louis, MO, USA2 Department of Radiation Oncology, Taipei, Taiwan, China3 College of Pharmacy, Lexington, KY, USA4 Department of Radiation Oncology, Nashville, TN
(PP167) Radiosensitization by the combination of 41°C hyperthermia and indomethacin analogs.
Sabapathi, Sathishkumar*,1, Mohiuddin, Mohammed 1, Ahmed, Mansoor1, 1 Radiation Medicine, Lexington, KY, USA
(PP168) Radiation-induced negative regulators of Sphingomyelin pathway: A potential target to overcome radioresistance in prostate cancer.
Sang, Mei*,1, Kang, Yun1, Patel, Nalini1, Travis, Elizabeth1, Terry, Nicholas1, 1 Experimental Radiation Oncology, Houston, Texas, USA
(PP169) Postirradiation treatment with recombinant human keratinocyte growth factor (rHuKGF) may ameliorate radiation-induced pneumonitis in mice.
Sarkaria, Jann*,1, Carlson, Brett1, Schroeder, Mark2, Ballman, Karla3, James, C. David2, 1 Department of Oncology, Rochester, MN, USA2 Department of Pathology, Rochester, MN, USA3 Department of Biostatistices, Rochester, MN, USA
(PP170) EGFR amplification does not correlate with radiation response of GBM xenografts.
Schaue, Dorthe*,1, Liao, Yu-Pei1, Comin-Anduix, Begonya2, Ribas, Antoni2, Debucquoy, Annelies3, Haustermans, Karin3, McBride, William1, 1 Department of Radiation Oncology, Los Angeles, CA, USA2 Department of Surgery, Division of Surgical Oncology, Los Angeles, CA, USA3 Department of Radiation Oncology, Leuven, V.Brabant, Belgium
(PP171) The effect of radiation therapy on tumor-specific immune responses.
Schnarr, Kara *,1, Dayes, Ian2, Sathya, Jinka2, McFarlane, Nicole1, Boreham, Douglas1, 1 Medical Physics and Applied Radiation Sciences, Hamilton, ON, CANADA2 Department of Radiation Oncology, Hamilton, ON, CANADA
(PP172) Radiation - induced apoptosis of lymphocytes to predict normal tissue late toxicity from radiotherapy.
Scott, Simon*,1, Greco, Olga 2, Murdoch, Craig1, Lewis, Claire1, 1 Division of Genomic Medicine, Sheffield, S. Yorks, United Kingdom2 Division of Clinical Sciences, Sheffield, S. Yorks, United Kingdom
(PP173) Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages.
Seed, T*,1, Inal , C2, Deen , J2, Aguilar, K1, 1 Vitreous State Laboratory, Washington, DC, USA2 Radiation Casualty Management, Bethesda, MD, USA
(PP174) Radioprotective effects of low dose amifostine prophylaxis on hematopoietic tissues.
Shah, Pratish*,1, Shajahan, Shahin1, Shareef, Mohammed1, Samayoa, Luis2, Kudrimoti, Mahesh1, Rowland, Randall3, Mohiuddin, Mohammed1, Ahmed, Mansoor1, 1 Department of Radiation Medicine, Lexington, KY, USA2 Department of Pathology, Lexington, KY, USA3 Department of Surgery (Division of Urology), Lexington, KY, USA
(PP175) Detection of PSA and Cytokeratin positive prostate tumor cells in post-brachytherapy peripheral blood samples by real-time quantitative RT-PCR and Flow Cytometry.
Nichols, Karen*,1, Crouse, David*,1, Sharp, John*,1, 1 School of Allied Health Professions, College of Medicine, Omaha, Nebraska, U.S.A.
(PP176) Evaluation of a radiation biology course taught in a computer-based distance learning accessible format.
Shi, Lei*,1, Sonntag, William2, Carter, Christy2, Robbins, Michael 3, Long, Ashley1, Bennett, Colleen 2, Brunso-Bechtold, Judy1, 1 Department of Neurobiology and Anatomy, Winston-Salem, NC2 Department of Physiology and Pharmacology, Winston-Salem, NC3 Department of Radiation Oncology, Winston-Salem, NC
(PP177) Whole brain irradiation leads to cognitive impairment in Fischer 344 X Brown Norway rats.
Siddiqui, Farzan*,1, Avery, Paul2, LaRue, Susan1, Hauck, Marlene 3, Dewhirst, Mark4, Li, Chuan- Yuan4, Ullrich, Robert1, 1 Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA2 Department of Microbiology, Immunology and Pathology, CO, Fort Collins, CO, USA3 Department of Clinical Sciences, Raleigh, NC4 Department of Radiation Oncology, Durham, NC, USA
(PP178) A Phase I Hyperthermia- induced Interleukin- 12 gene- therapy trial in spontaneously arising feline soft tissue sarcomas.
Singh, Vijay*,1, Shafran, Randi1, Sree Kumar, K1, 1 Radiation Casualty Management Team, Bethesda, MD, USA
(PP179) Induction of hematopoietic cytokines and chemokines by radioprotectant tocols.
Smith, Pameeka*,1, Zhao, Weiling 1, Robbins, Mike, 1 Brain Tumor Center of Excellence & Department of Radiation Oncology, Winston-Salem, NC, USA
(PP180) Targeting antioxidant enzymes in anti-glioma therapies.
Singh, Vijay1, Shafran, Randi1, Hieber, Kevin1, Seed, Thomas1, Sree Kumar, K.1, 1 Radiation Casualty Management Team, Bethesda, MD
(PP181) Radioprotective efficacy and cytokine profile induced by a novel radioprotectant, ON01210.
Stieber, Volker*,1, Robbins, Michael 1, Balamucki, Christopher3, de Guzman, Alan1, Tatter, Stepehn2, Ekstrand, Kenneth1, Munley, Michael1, Branch, Charles2, Shaw, Edward1, Bourland, J.2, Lovato, James4, Ellis, Thomas2, 1 Wake Forest University, Winston-Salem, NC, United States3 Wake Forest University, Winston-Salem, NC, United States2 Wake Forest University, Winston-Salem, NC, United States4 Wake Forest University, Winston-Salem, NC, United States
(PP182) Calculation of repair half-time of the trigeminal nerve after gamma knife radiosurgery (GKRS) using clinical data from 256 procedures for trigeminal neuralgia.
Sultanov, Marianna*,1, Mohiuddin, Mohammed1, Ahmed, Mansoor1, 1 Radiation Medicine, Lexington, KY, USA
(PP183) Effect of high-dose spatially fractionated GRID radiation on regression of distant human lung tumor xenografts.
Hou, Huagang1, Khan, Nadeem1, Yu, Hongsheng1, Demidenko, Eugene1, O'Hara, Julia1, Swartz, Harold*,1, 1 EPR Center for the Study of Viable Systems, Hanover, NH, USA
(PP184) Observation of increase of oxygen in experimental murine tumors approximately 20 minutes after x-ray irradiation.
Du, Min1, Zhou, Xinhui1, Ramdas, Latha1, Allard, John2, Peltz, Gary2, Travis, Elizabeth*,1, 1 Experimental Radiation Oncology/Radiation Oncology, Houston, TX, USA2 Genetics and Genomics, Palo Alto, CA, USA
(PP185) The biological pathways for radiation-induced lung injury in mice.
Trncic, Nadira *,1, Kraft, Susan1, Dewhirst, Mark2, LaRue, Susan1, 1 Department of Environmental and Radiological Health Sciences, Fort Collins, Colorado, USA2 Department of Radiation Oncology, Durham, Nort Carolina, USA
(PP186) Tumor microenvironment and reoxygenation.
Mason, Kathy1, Valdecanas, David*,, Neal, Robert, Hunter, Nancy, Ang, Kian2, Milas, Luka, 1 Experimental Radiation Oncology, Houston, TX, USA2 Radiation Oncology, Houston, TX, USA
(PP187) CpG oligodeoxynucleotides (CpG ODNs) enhance response of murine tumors to docetaxel.
Buckley, Michael1, Emmolo, Joanna1, Devitt, Mary1, Roth, Jennifer1, Dewyngaert, J Keith1, Peter, Brooks2, Liebes, Leonard1,3, Formenti, C Silvia1,3, Vlachaki, Maria Theodoros*,1, 1 Radiation Oncology, New York, NY, USA2 Cell Biology, New York, NY, USA3 New York University Cancer Institute, New York, NY, USA
(PP188) Para-aminobenzoic acid (PABA) and high radiation dose rates modulate response to ionizing radiation in experimental lung cancer models.
Wachsberger, Phyllis *,1, Burd, Randy1, Marrero, Nichol1, Rossetti, Dianne1, Strickler, Tara 1, Yancopoulos, George2, Holash, Jocelyn2, Dicker, Adam1, 1 Department of Radiation Oncology, Philadelphia, PA, USA2 Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA
(PP189) Improvement of fractionated radiation therapy by combination with a VEGF blocker, VEGF Trap.
Wang, Junru*,1, Qiu, Xiaohua1, Kulkarni, Ashwini1, Hauer-Jensen, Martin1, 1 Arkansas Cancer Research Center, Little Rock, AR
(PP190) Regulation of the acute intestinal radiation response by calcitonin gene-related peptide (CGRP) and substance P (SP).
Mayr, Nina1, Nag, Subir1, Montebello, Joseph1, Gupta, Nilendu1, Kanellitsas, Christos1, Samsami, Nina1, Wang, Jian1, 1 Department of Radiation Medicine, Columbus, OH, USA
(PP191) Effect of edema, relative biological effectiveness and dose heterogeneity on prostate brachytherapy.
Wang, Tao*,1,2, Languino, Lucia2,3, FitzGerald, Thomas1,4, 1 Univ. of Massachusetts Medical School, Worcester, MA, United States2 Univ. of Massachusetts Medical School, Worcester, MA, United States3 Univ. of Massachusetts Medical School, Worcester, MA, United States4 Univ. of Massachusetts Medical School, Worcester, MA, United States
(PP192) Low dose ionizing radiation does not affect the expression of 
1 integrin and EGF receptor in DU-145 and PC3 prostate cancer cells.
Wang, Zhong-He*,1, Wang, Ming-Guo1, Hu, Hai-Sheng1, 1 Shanghai Second Medical University, Shanghai, China
(PP193) Enhanced anit-tumor effect of mab225 in combination with radiation for humon tongue squamous cell carcinoma cell line.
Welsh, James*,1, 1 University of Wisconsin-Madison, Wisconsin Rapids, WI, USA
(PP194) Periodic irradiation from the cosmos over geologic history: potential biological impact.
Whitehead, Timothy *,1, Deasy, Joseph 1, Roti Roti, Joseph 1, 1 Radiation Oncology, St Louis, MO, USA
(PP195) Simulating tumor response to fractionated radiotherapy using a bioreactor.
Wiedenmann, Nicole*,1, 2, Neal, Robert1, Hunter, Nancy1, Raju, Uma1, Milas, Luka1, Mason, Kathy1, 1 Department of Experimental Radiation Oncology, Houston, TX, USA2 Department of Radiation Oncology, Munich, D, Germany
(PP196) In vivo interaction of single dose radiation with G3139, a Bcl-2 antisense oligonucleotide.
Wlodarczyk, Waldemar*,1, Gellermann, Johanna1, Nadobny, Jacek1, Felix, Roland 1, Wust, Peter1, 1 Charite Medical University, Berlin, Germany
(PP197) Magnetic resonance monitoring of temperature distributions in patients undergoing regional hyperthermia: accuracy and guidance in clinical routine.
Hossain, Moazzem1, Atkinson, Shelley1, Li, Yu Qing1, Wong, Shun*,1, 1 Radiation Oncology, Toronto, Ontario, Canada
(PP198) Systemically administered erythropoietin protects the irradiated brain through anti-inflammatory mechanisms.
Mocanu, Joseph1, Au, P. Y.2, Sleep, Gillian1, Yeh, Wen-Chen2, Gilbert, Ralph3, O Sullivan, Brian4, Gullane, Patrick3, Bastianutto, Carlo1, Liu, Fei-Fei1,4, Yip, Kenneth*,1, 1 Applied Molecular Oncology, Toronto, ON, Canada2 Advanced Medical Discovery Institute, Toronto, ON, Canada3 Surgical Oncology, Toronto, ON, Canada4 Radiation Oncology, Toronto, ON, Canada
(PP199) Combination Bcl-2 antisense and radiation therapy for nasopharyngeal cancer.
Yong, Kwon-Joong*,1, Velena, Alfredo 1, Chen, Bin2, Petukhov, Pavel2, Kozikowski, Alan2, Dritschilo, Anatoly 1, Jung, Mira1, 1 Department of Radiation Medicine, Lombadi Cancer Center, Washington, D.C., USA2 Department of Medical Chemistry and Pharmacognosy, Chicago, IL, USA
(PP200) Identification of Novel HDAC Inhibitors with Radiosensitizing Properties.
Song, Jie-Young 1, Lim, Hee-Soon 1, Kim, Hyung-Doo , Han, Youngsoo1, Son, Hyeog-Jin 1, Yun, Yeon-Sook1, 1 Laboratory of Radiation Immunology, nowon-ku, Seoul, Republic of Korea
(PP201) Development of biomarkers in radiation-induced lung damages.