Stem Cells in Radiation Biology
Tuesday, October 18, 2005 7:45 AM-8:45 AM Room No. 603(TR008) Stem cells in radiation biology.
Greenberger, Joel*,1, 1 Radiation Oncology Department, Pittsburgh, PA, USA
ABSTRACT- The critical role of self-renewing stem cells in normal tissue and organ repair of ionizing irradiation damage is well established. New paradigms (some of which are highly controversial) have appeared in recent years. These include:1) transdifferentiation of bone marrow stromal cells(mesenchymal stem cells) into multiple lineages including chondrocyte, osteoblast, striated muscle, and adipocyte:2)epithelial differentiation capacity of bone marrow stem cells into lung, intestine, esophagus,neuroglia, cardiac and skeletal muscle and pancreas, including B-islet cells, skin, and other tissues;3)controversial new in vitro asays for stem cells, and 4) delineation of specific differences between embryonic and adult tissue stem cells. The radiation biology of stem cells is of obvious great importance in basic and clinical translational research..
Key words: stem cells, radiation, bone marrow