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Chair(s): Hall, Eric
(SY030) A role for secreted soluble factors in communicating the radiation response to non-irradiated cells.
Morgan, William ,
ABSTRACT- Radiation induced genomic instability and bystander effects are two of a number of non-targeted effects associated with exposure to ionizing radiation. In this presentation the hypothesis that cellular exposure to ionizing radiation can result in the secretion of soluble factors by irradiated cells and/or their progeny, and that these factors can elicit responses in other cells thereby initiating and perpetuating ongoing genomic instability will be presented. The evidence for a role for secreted soluble factors in communicating the radiation response that leads to delayed chromosomal instability, induced bystander effects, clastogenic factors, death inducing effects and abscopal effects in non-irradiated cells will be covered. This work was supported by the Biological and Environmental Research Program (BER), U.S. Department of Energy, Grant No. DE-FG02-01ER63230 and National Institute of Health Awards CA73924 and CA 83872.
Key words: genomic instabillity, non-targeted effects, death inducing effect, secreted soluble factors
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