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Chair(s): Mitra, Sankar
(SY004) Biological functions of RecQ helicases mediated by their interactions with human Rad2 nucleases.
Brosh Jr., Robert *,1, 1 Laboratory of Molecular Gerontology, Baltimore, MD, USA
ABSTRACT- The human RecQ helicase disorders Werner syndrome and Bloom syndrome are characterized by elevated genomic instability, cancer, and/or premature aging. Biochemical, cellular, and genetic studies indicate that RecQ helicases modulate Rad2 (Flap Endonuclease-1, Exonuclease-1) nucleolytic processing of key DNA replication and repair intermediates to preserve genomic integrity.
Key words: Werner Syndrome, Bloom Syndrome, Flap Endonuclease 1, Exonuclease 1
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