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PARENT SESSION

DNA Repair: Recent Advances in the Base Excision Repair Pathway

Sunday, October 16, 2005 10:15 AM-12:00 PM Room No. 601
Chair(s): Mitra, Sankar

(SY004) Biological functions of RecQ helicases mediated by their interactions with human Rad2 nucleases.

Brosh Jr., Robert *,1, 1 Laboratory of Molecular Gerontology, Baltimore, MD, USA

ABSTRACT- The human RecQ helicase disorders Werner syndrome and Bloom syndrome are characterized by elevated genomic instability, cancer, and/or premature aging. Biochemical, cellular, and genetic studies indicate that RecQ helicases modulate Rad2 (Flap Endonuclease-1, Exonuclease-1) nucleolytic processing of key DNA replication and repair intermediates to preserve genomic integrity.

Key words: Werner Syndrome, Bloom Syndrome, Flap Endonuclease 1, Exonuclease 1


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2005 RRS