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Chair(s): Pogozelski, Wendy; Hill, Helene
(SY039) Mitochondrial DNA mutations and cancer.
Turner, Joan1, 1 Experimental Oncology, Edmonton, AB, Canada
ABSTRACT- Mitochondrial (mt) DNA mutations have been reported in a variety of human tumors, with the D-loop and Complex I genes being mutational hotspots. The current paradigm suggests a pathogenic role for mtDNA mutations in human cancer through altered redox balance, leading to increased ROS production and a state of continuous oxidative stress. Ultimately, these conditions may lead to the development of a more aggressive tumor phenotype and poor clinical outcome. We will review evidence in support of a relationship between mtDNA mutations, tumor treatment response and prognosis, and discuss novel strategies that focus on mitochondria as potential therapeutic targets.
Key words: mitochondria, mtDNA mutations
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