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Chair(s): Hauer-Jensen, Martin
(SY053) Targeting drug delivery to radiation-inducible neoantigens within microvasculature of cancer.
Hallahan, Dennis*,1, 1 Department of Radiation Oncology, Nashville, TN
ABSTRACT- Proteomic analysis of membrane proteins following irradiation have identified a number of cell adhesion molecules and receptors that are induced or activated in response to ionizing radiation. In addition to mediating radiation induced inflammation and blood flow, these receptors also represent targets for drug delivery. We have developed antibodies and peptide ligands that bind to these radiation inducible proteins on the surface of tumor vasculature. Antibodies targeted to these cell adhesion molecules (P-selective) achieve tumor specific binding following irradiation. These antibodies demonstrate rapid clearance from circulation and sustained binding with tumor vasculature. Peptide ligands to radiation activated receptors also achieve rapid clearance and sustained binding within tumor blood vessels. In addition to providing targeting technology, these peptide ligands also have biological efficacy in irradiated tumors.
Key words: tumor vasculature, radiation response, cell adhesion molecules, targeted drug delivery
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