RRS 2005

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PROGRAM

Plenary Sessions

SESSION A

Weissleder, Ralph¹, ¹ Center for Molecular Imaging Research, Charlestown, MA, USA
(PS001) Advances in Molecular Imaging.

SESSION B

Lavin, Martin¹, ¹ Cancer Research Unit, Brisbane, Australia
(PS002) Role of ATM in DNA Damage Recognition.

SESSION C

Bissell, Mina¹, ¹ Lawrence Berkely National Laboratory, Berkeley, CA, USA
(PS003) Tissue Context & Architecture Determine Functional Behavior and Response to Damage.

SIT: What's Hot (Joint RRS-ASTRO Plenary)

Folkman, Judah¹, ¹ Children's Hospital, Boston, MA, USA
(PS004) Angiogenesis and the Radiation Response.

Special Sessions

President's Symposium

Douple, Evan¹, ¹ The National Academies, Washington, DC, USA
(SS001) Radiation Risk Assessment and the Committee on Biological Effects of Ionizing Radiation (BEIR VII).

Dewey, William¹, ¹ University of California, San Francisco, San Francisco, CA, USA
(SS002) Biology and Genetics in the Biological Effects of Ionizing Radiation (BEIR VII).

Gilbert, Ethel¹, ¹ National Cancer Institute, Bethesda, MD, USA
(SS003) The Biological Effects of Ionizing Radiation (BEIR VII) Models for Estimating Cancer Risks.

Waldren, Charles^1,2, ¹ Radiation Effects Research Foundation (RERF), Hiroshima/Nagasaki, Japan² Environmental and Radiologic Health Sciences (ERHS), Fort Collins, CO, USA
(SS004) Radiation Mutagenesis: Size Matters.

Michael Fry Research Lecture

Lobrich, Markus^*,1, ¹ Biophysics Department, Homburg, Saar, Germany
(SS005) Pathways of Double-Strand Break Repair After Ionizing Irradiation.

Marie Curie Award Lecture

Topical Reviews

Enhancements of Medical Countermeasures for Nuclear and Radiological Events — A Biodosimetry Perspective

Blakely, William^*,1, ¹ Biological Dosimetry Team, Bethesda, MD, USA
(TR001) Enhancements of medical countermeasures for nuclear and radiological events — a biodosimetry perspective.

Tips from a Journal Editor on Writing Scientific Papers

Rockwell, Sara ¹, ¹ Department of Therapeutic Radiology, New Haven, CT, USA
(TR002) Tips from a journal editor on writing scientific papers.

Nuclear Architecture in Relation to Chromosome Damage and Cell Kill

Aten, Jacob ^*,1, ¹ Dept of Cell Biology and Histology, Amsterdam, The Netherlands
(TR003) Nuclear architecture in relation to chromosome damage and cell kill.

Telomeres and Double-Strand Breaks: Tying up Loose Ends

Bailey, Susan^*,1, ¹ Environmental & Radiological Health Sciences, Fort Collins, CO
(TR005) Telomeres and double-strand breaks: tying up loose ends.

Microbeams and Bystander effects

Prise, Kevin^*,1, ¹ Cell & Molecular Radiation Biology, Northwood, Middlesex, UK
(TR006) Microbeams and bystander effects.

Current Status of C. elegans Radiobiology

Nelson, Gregory^*,1, ¹ Radiobiology Program, Loma Linda, CA, USA
(TR007) Radiobiology of C. elegans.

Stem Cells in Radiation Biology

Greenberger, Joel^*,1, ¹ Radiation Oncology Department, Pittsburgh, PA, USA
(TR008) Stem cells in radiation biology.

Signal Transduction in Radiotherapy Treatment

McKenna, Gillies¹, ¹ Radiation Oncology & Biology, Oxford, United Kingdom
(TR009) Signal transduction in radiotherapy treatment.

Radio-Resistance and Sensitivity of Organisms in the Environment; the Cockroaches Bid for World Domination

Mothersill, Carmel¹, ¹ Medical Physics and Applied radiation Sciences, Hamilton, Ontario, Canada
(TR010) Radioresistent organisms - or the cockroaches' bid for world domination.

Direct Radiation Damage in DNA from Free Radical Formation to End Products

Bernhard, William^*,1, ¹ Biochemistry and Biophysics, Rochester, NY, USA
(TR011) Direct radiation damage in DNA from free radical formation to end products.

Engaging the Vascular Component of the Tumor Response

Kolesnick, Richard¹, ¹ Laboratory of Signal Transduction and Departments, New York, NY, USA
(TR012) Engaging the vascular component of the tumor response.

Symposia

DNA Repair: Recent Advances in the Base Excision Repair Pathway

Mitra, Sankar^*,1, Dou, Hong¹, Wiederhold, Lee¹, Mokkapati, Sanath¹, Chattopadhyay, Ranajoy¹, Bhakat, Kishor¹, Hazra, Tapas¹, ¹ Sealy Center for Molecular Science, Galveston, TX, USA
(SY001) Repair of oxidative damage in the mammalian genome: a complex picture.

Dianov, Grigory ^*,1, Dianova, Irina ¹, Parsons, Jason¹, ¹ Radiation & Genome Stability Unit, Harwell, Oxfordshire, United Kingdom
(SY002) Processing of 3'-end modified DNA strand breaks induced by ionizing radiation.

Satoh, Masahiko^*,1, ¹ Division of Health and Environmental Research, Ste-Foy, Quebec, Canada
(SY003) Molecular mechanism of BER-mediated double strand DNA break formation.

Brosh Jr., Robert ^*,1, ¹ Laboratory of Molecular Gerontology, Baltimore, MD, USA
(SY004) Biological functions of RecQ helicases mediated by their interactions with human Rad2 nucleases.

Molecular Targeting of Apoptotic Pathways

Mason, Kathy^*,1, ¹ Experimental Radiation Oncology/Division of Radiation Oncology, Houston, TX, USA
(SY005) Radiation enhancement using an antisense Bcl-2 strategy.

Verheij, Marcel^{*,1, 2}, Vink, Stefan¹, Van der Luit, Arnold², Van Blitterswijk, Wim², ¹ Department of Radiation Oncology, Amsterdam, NH, The Netherlands² Division of Cellular Biochemistry, Amsterdam, NH, The Netherlands
(SY006) Combined treatment of the alkyl-phosphocholine Perifosine and radiation: Apoptosis modulation from bench to bedside.

Meyn, Raymond^*,1, ¹ Experimental Radiation Oncology/Radiation Oncology, Houston, TX, USA
(SY007) Death receptor mediated cancer therapy using TNF-related apoptosis-inducing ligand.

Radiation-Induced Cell Cycle Checkpoints

O'Connell, Matthew¹, ¹ Department of Oncological Sciences, New York, NY
(SY008) Chk1 signaling in the G2 DNA damage checkpoint.

Muschel, Ruth ^{*,1, 2}, Fletcher, Lynda¹, Huang, Haomin ¹, Zhang, Wei¹, Kao, Gary², Yen, Tim³, ¹ Pathology, Philadelphia, PA, USA² Radiation Oncology, Philadelphia, PA, USA³ Institute for Cancer Research, Philadelphia, PA, USA
(SY009) DNA damage: Centrosome separation and cytokinesis.

Iliakis, George^*,1, Wang, Huichen², Rosidi, Bustanur¹, Wang, Minli¹, Windhofer, Frank¹, Zhang, Lihua¹, Wang, Ya, ¹ Institute of Medical Radiation Biology, Essen, NRW, Germany² Department of Radiation Oncology, Philadelphia, PA, USA
(SY010) Pathways of DNA double strand break repair and checkpoint response.

Syljuåsen, Randi^*,1, Sørensen, Claus¹, Lukas, Jiri¹, Bartek, Jiri¹, ¹ Department of Cell Cycle and Cancer, Institute of Cancer Biology, Copenhagen, Denmark, Denmark
(SY011) Targeting checkpoint kinases to modulate tumor radiosensitivity.

Ion Beams from Physics to Therapy

Adhikary, Amitava¹, Sevilla, Michael¹, Becker, David^*,1, ¹ Chemistry, Rochester, MI, United States
(SY012) Ion beam irradiation of DNA: LET effects on radiation production of sugar-phosphate backbone radicals.

Taucher-Scholz, Gisela^*,1, ¹ Biopysics, Darmstadt, Hessen, Germany
(SY013) Dynamics of repair-protein localization to particle tracks.

Chang, Polly^*,1, ¹ Molecular and Genetic Toxicology/Biosciences Division, Menlo Park, CA, USA
(SY014) Transgenic mouse mutation models and heavy ion effects.

Kraft, Gerhard¹, Debus, Jürgen^*,2,3, ¹ Biophysics, Darmstadt, Germany, Germany² Dept of Radiotherapy, 69120-Heidelberg, Germany³ Dept of Clinical Radiology, Heidelberg, Germany, Germany
(SY015) Radiotherapy with heavy ion beams.

Signaling Mediated by Reactive Oxygen Species

Tonks, Nicholas^*,1, ¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
(SY016) Reversible oxidation of protein tyrosine phosphatases and the regulation of signal transduction.

Gius, David^*,1, ¹ Molecular Radiation Oncology Section, Radiation Oncology Branch, Bethesda, MD, USA
(SY017) Chronic hypoxia/preferfusion induced Oxidative Stress activates methyltransferase activity to induce expression of the BAG pro-survival gene family via the testis specific insulator protein BORIS.

Bakin, Andrei¹, Sekhar, Konjeti², Arteaga, Carlos³, Freeman, Michael ^*,2, ¹ Cancer Genetics, Buffalo, NY, USA² Radiation Oncology, Nashville, TN, USA³ Medical Oncology, Nashville, TN, USA
(SY018) TGF beta suppression of Nrf2-mediated transcription elevates ROS.

Gene Therapy and the Radiation Response

Worthington, Jenny², McCarthy, Helen¹, Xiang, Juan-juan¹, Adams, Catherine¹, Barrett, Eimear², Scott, Simon³, Wagner, Ernst⁴, Robson, Tracy¹, Hirst, David^*,1, ² School of Biomedical Sciences, Coleraine, Co. Londonderry, UK¹ School of Pharmacy, Belfast, Co. Antrim, UK³ Division of Genomic Medicine, Sheffield, Yorkshire, UK⁴ Pharmaceutical Biology-Biotechnology, Munchen, Bavaria, Germany
(SY019) Nitric oxide in cancer therapy: small but effective.

Borrelli, Michael¹, ¹ Radiation Oncology Research Laboratories, Royal Oak, MI, USA
(SY020) Hyperthermic control of a radiomimetic suicide gene.

Lambin, Philipe¹, ¹ Department of Radiation Oncology, Maastricht, The Netherlands
(SY021) Tumor-specific gene delivery using genetically engineered bacteria.

Freytag, Svend^*,1, Kim, Jae Ho¹, Brown, Steve, Stricker, Hans², Pegg, Jan¹, Lu, Mei³, ¹ Department of Radiation Oncology, Detroit, MI, USA² Vattakuti Urology Institute, Detroit, MI, USA³ Department of Biostatistics, Detroit, MI, USA
(SY022) Clinical trials combining oncolytic viral therapy and suicide gene therapy with radiotherapy.

Latest on Radiation-Induced Carcinogenesis

Yuan, Zhi-Min ^*,1, ¹ Dept. of Genetics and Complex Disease, Boston, MA, USA
(SY023) Ionizing radiation disrupts epithelium-stroma interactions, a potential mechanism for IR-induced carcinogenesis.

Mitchel, Ron^*,1, ¹ Radiation Biology and Health Physics, Chalk River, Ontario, Canada
(SY024) Cancer and low dose responses in vivo: Implications for radiation protection.

Dontu, Gabriela ^*,1, Liu, Suling¹, Wicha, Max, ¹ Internal Medicine/Hematology-Oncology, Ann Arbor, MI
(SY025) Breast cancer stem cells - biology and therapeutic implications.

Barcellos-Hoff, Mary Helen ^*,1, ¹ Cancer Biology, Life Sciences Division, Berkeley, CA, USA
(SY026) Radiation reveals novel roles for TGFb1 as a tumor suppressor.

The Bystander Effect

Wright, Eric^*,1, ¹ Department of Molecular and Cellular Pathology, Dundee, Angus, Scotland, UK
(SY027) Bystander interactions in hemopoietic tissue responses to ionizing radiation.

Hall, Eric ^*,1, ¹ Center for Radiological Research, New York, NY, USA
(SY028) The bystander effect demonstrated by a charged particle microbeam.

Azzam, Edouard^*,1, Little, John², ¹ Department of Radiology/Division of Radiation Research, Newark, NJ, USA² Center for Radiation Sciences and Environmental Health, Boston, MA, USA
(SY029) The role of intercellular communication and oxidative metabolism in the propagation of low-level radiation effects.

Morgan, William ,
(SY030) A role for secreted soluble factors in communicating the radiation response to non-irradiated cells.

Biology and Potential Therapeutic Applications of Stem Cells

Hsu, Michael¹, Barchas, Laurel¹, Rossi, Derrick², Conboy, Michael³, Rando, Thomas³, Barcellos-Hoff, Mary-Helen⁴, Weissman, Irv³, Conboy, Irina^*,1, ¹ Bioengineering, Berkeley, CA² Pathology, Stanford, CA³ Neurology, Stanford, CA⁴ Cancer Biology, Berkeley, CA
(SY031) Understanding stem cell aging.

Hlatky, Lynn^*,1, ¹ Vascular Biology Program, Boston, MA, USA
(SY032) Radiation-induced modulation of circulating endothelial progenitors.

Greenberger, Joel^*,1, ¹ Radiation Oncology, School of Medicine, Pittsburgh, PA, USA
(SY033) Stem cells in radiation biology.

West, Michael^*,,
(SY034) Opportunities and challenges in the use of human embryonic stem cells and nuclear transfer.

Mitochondria and Radiation Damage

Pogozelski, Wendy^*,1, ¹ Department of Chemistry, Geneseo, NY, USA
(SY035) Introduction to mitochondria and mitochondrial DNA.

Bohr, Vilhelm^*,1, de Souza-Pinto, Nadja ¹, ¹ Laboratory of Molecular Gerontology, Baltimore, MD, USA
(SY036) DNA repair in mammalian mitochondria.

Pogozelski, Wendy¹, Steinberg, Mark², Hubbard, Karen³, Orlow, Irene⁴, Dermody, James⁵, Hill, Helene^*,5, ¹ Department of Chemistry, Geneseo, NY, US² Department of Chemistry, New York, NY, US³ Department of Biology, New York, NY, US⁴ Epidemiology and Biostatistics Department, New York, NY, US⁵ Department of Microbiology and Molecular Genetics, Newark, NJ, US
(SY037) Radiation and mitochondrial DNA deletions.

Slane, Benjamin¹, Aykin-Burns, Nukhet ¹, Domann, Frederick¹, Spitz, Douglas^*,1, ¹ Radiation Oncology, Free Radical & Radiation Biology Program, Iowa City, IA, USA
(SY038) A mutation in succinate dehydrogenase subunit C (SDHC) confers sensitivity to low dose ionizing radiation.

Turner, Joan¹, ¹ Experimental Oncology, Edmonton, AB, Canada
(SY039) Mitochondrial DNA mutations and cancer.

Radiation-Induced Genomic Instability

Mothersill, Carmel ^*,1, Seymour, Colin ¹, ¹ Medical Physics and Applied Radiation Sciences, Hamilton, Ontario, Canada
(SY040) Factors involved in sectoring to death or genomic instability in cells.

Sowa, Marianne ^*,1, Morgan, William², ¹ Chemical Structure and Dynamics, Richland, WA, USA² Radiation Oncology Research Laboratory, Baltimore, MD, USA
(SY041) Examining low-Let radiation induced genomic instability with microbeam irradiation techniques.

Sabatier, Laure², Murnane, John ^*,1, ² Laboratoire de Radiobiologie et Oncologie, Fonenay-aux Roses, BP6, France¹ Department of Radiation Oncology, San Francisco, CA, United States
(SY042) The consequences of telomere loss for chromosomal instability.

Niwa, Ohtsura^*,1, ¹ Radiation Biology Center, Kyoto, Kyoto, Japan
(SY043) Genetics meets epigenetics at the crossroads of chromatin.

Low Energy Electrons and DNA Damage

Ray, Supratim¹, Daube, Shirley², Naaman, Ron^*,1, ¹ Dep. of Chemical Physics, Rehovot, Israel, Israel² Chemical Research Support, Rehovot, Israel, Israel
(SY044) Capturing of low-energy electrons by DNA.

Li, Xifeng ¹, Sanche, Léon¹, Sevilla, Michael ^*,, ¹ Dept of Nuclear Medicine and Radiobiology, Sherbrooke, Quebec, Canada
(SY045) Density functional theory treatment of low energy electron attack on DNA.

Bass, Andrew^*,1, Sanche, Leon¹, ¹ Dept. of Nuclear Medicine and Radiobiology, Sherbrooke, QC, Canada
(SY046) Investigating secondary electron damage to DNA by electron stimulated desorption from thin films of DNA and its molecular components.

Ptasinska, Sylwia¹, Denifl, Stephan¹, Grill, Verena¹, Rondino, Flaminia¹, Zappa, Fabio¹, Illenberger, Eugen², Märk, Tilmann¹, Scheier, Paul^*,1, ¹ Institut für Ionenphysik, Innsbruck, Austria, Austria² Institut für Physikalische und Theoretische Chemie, Berlin, Germany, Germany
(SY047) Isotope and site labeling for the identification of resonances in dissociative electron attachment to biomolecules.

Chromatin Remodeling and DNA Repair

Kruhlak, Michael ¹, Celeste, Arkady¹, Capetillo, Oscar ¹, Dellaire, Graham ², Bazett-Jones, David², Nussenzweig, Andre^*,1, ¹ Experimental Immunology Branch, Bethesda, MD² Hospital for Sick-Kids, Tononto, Toronto, Canada
(SY048) Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.

Adams, Peter^*,1, ¹ Basic Science, Philadelphia, PA, USA
(SY049) Cellular responses to chromatin damage.

Huyen, Yentram¹, Zgheib, Omar¹, DiTullio, Richard¹, Stavridi, Elena¹, Halazonetis, Thanos^*,1, ¹ Molecular Oncogenesis Program, Philadelphia, PA, USA
(SY050) 53BP1 as a sensor of DNA double strand breaks.

Osley, Mary Ann¹, ¹ University of New Mexico, Albuquerque, NM, USA
(SY051) Chromatin remodeling during DSB repair.

Radiation Endotheliology

Kolesnick, Richard¹, ¹ Molecular Pharmacology and Chemistry, New York, New York, USA
(SY052) Reorganization of membrane rafts into large signaling platforms in endothelium initiates apoptosis.

Hallahan, Dennis^*,1, ¹ Department of Radiation Oncology, Nashville, TN
(SY053) Targeting drug delivery to radiation-inducible neoantigens within microvasculature of cancer.

Stewart, Fiona^*,,
(SY054) Radiation induced atherosclerosis: mechanisms and possible intervention strategies.

Hauer-Jensen, Martin^*,1, ¹ Arkansas Cancer Research Center, Little Rock, AR
(SY055) Modulating normal tissue radiation toxicity using endothelial-oriented approaches.

The Risks of Radiation at Low Doses

Mullenders, Leon¹, ¹ Leiden University Medical Center, Leiden, The Netherlands
(SY056) Early genomic and cellular responses to ionizing radiation.

Sabatier, Laure^*,1, ¹ Radiobiology and Oncology Unit, Fontenay-aux-Roses, IdF, FRANCE
(SY057) Delayed and epigenetic effect of ionizing radiation Contribution of cellular ageing and genomic instability to multi-stage tumour development.

Bouffler, Simon^*,1, ¹ Radiation Protection Division, Chilton, Oxfordshire, UK
(SY058) RISC RAD workpackage 3: pre-neoplastic lesions and tumour development.

Atkinson , Michael^*,1, ¹ RISCRAD Consortium, EURATOM, EU
(SY059) The RISCRAD study of the genetic risks of radiation carcinogenesis.

Paretzke, Herwig¹, ¹ Institute of Radiation Protection, Neuherberg, Germany
(SY060) Modeling for radiation risk assessment.

Chemistry and Biology of Deoxyribose Oxidation

Bryant-Friedrich, Amanda^*,1, Lahoud, Georges ¹, ¹ Department of Chemistry, Rochester, MI, United States
(SY061) The role of the C-3′-nucleotide radical in DNA damage.

Razskazovskiy, Yuriy^*,1, Roginskaya, Marina², Bernhard, William², ¹ Physics, Astronomy and Geology, Johnson City, TN, USA² Biochemistry and Biophysics, Rochester, NY, USA
(SY062) Yields and decomposition of 2′-deoxyribonolactone desions in irradiated DNA and chromatin.

Dedon, Peter^*,1, ¹ Biological Engineering Division, Cambridge, MA, USA
(SY063) Chemical approaches to defining the biological consequences of radical-mediated deoxyribose oxidation in DNA.

Demple, Bruce^*,1, ¹ Dept. of Genetics & Complex Diseases, School of Public Health, Boston, MA, USA
(SY064) Ape1, DNA polymerase-beta and the repair of oxidized abasic sites: Roadblocks, detours and divided highways.

Workshops

Career Development

Hallahan, Dennis¹, ¹ Department of Radiation Oncology, Nashville, TN, USA
(WS001) Grantsmanship & Mentoring Programs.

Stone, Helen¹, ¹ National Cancer Institute, Bethesda, MD, USA
(WS002) Organization of NIH.

Hong, Bo,
(WS003) Grant Review Process.

Gius, David¹, ¹ National Cancer Institute, Bethesda, MD, USA
(WS004) Current Priorities at NASA, DOD, DOE & DHS.

Space Explorations in the 21st Century

Chang-Diaz, Franklin¹, ¹ Advanced Space Propulsion Laboratory, Houston, TX, USA
(WS005) Near & deep space explorations--a broad view of planned programs.

Cucinotta, Francis¹, ¹ NASA Johnson Space Center, Houston, TX, USA
(WS006) Models of space radiation risks and uncertainties.

Fike, John¹, ¹ Department of Neurological Surgery, San Francisco, CA, USA
(WS007) High LET irradiation induces long-term reductions of neural precursor cells and their progeny.

Clark, Jonathan¹, ¹ National Space Biomedical Research Institute, Houston, TX, USA
(WS008) Space medicine in the 21st century.

Radiation and the Environment: Mechanistic Approaches to the Understanding of Low Dose Effects

Hinton, Tom ¹, ¹ Savannah River Ecology Laboratory, Aiken, SC, USA
(WS009) Determining the effects of radiation on the environment: A need to link molecular injury to population-level impacts.

Boreham, Doug¹, ¹ Medical Physics and Applied Radiation Sciences Unit, Hamilton, ON, Canada
(WS010) Development of molecular tools for investigation of radiation effects in the environment.

Dynan, William¹, ¹ Medical College of Georgia, Augusta, GA, USA
(WS011) DNA damage response and Ku80 function in the vertebrate embryo.

Lyng, Fiona,
(WS012) Low dose radiation effects in fish.

Preparing for Radiological Terrorism

Purucker, Mary ¹, ¹ Food & Drug Administration, Rockville, MD, USA
(WS013) Regulations affecting drug development.

Pesik, Nicki¹, ¹ Centers for Disease Control & Prevention, Atlanta, GA, USA
(WS014) Federal preparedness for radiation countermeasures.

Pellmar, Terry ¹, ¹ Armed Forces Radiobiology Research Institute, Bethesda, MD, USA
(WS015) Research efforts: Drugs in the pipeline.

Coleman, C Norman¹, ¹ National Institute of Health, Bethesda, MD, USA
(WS016) Medical countermeasures: Pre- and Post- exposure intervention.

Radiation Risk From Chronic Low-Dose Rate Radiation Exposures: The Role of Life-Time Animal Studies

Goodhead, Dudley¹, ¹ Radiation and Genome Stability Unit, Harwell, United Kingdom
(WS017) Review of the 'Committee Examining Radiation Risks of Internal Emitters'.

McLellan, Roger ¹, ¹ , Albuquerque, NM, USA
(WS018) Review of the health effects of internally deposited radioactive materials in the beagle.

Woloschak, Gayle¹, ¹ Northwestern University, Chicago, IL, USA
(WS019) The tissue and data from the long term animal studies: How useful are they in risk assessment?

Brooks, Antone ¹, ¹ Washington State University TriCities, Richland, WA, 99352
(WS020) Cell and molecular studies with internally deposited radioactive materials.

Mini-Symposia

Genomic Maintenance and Repair

Krempler, Andrea¹, Deckbar, Dorothee¹, Tchouandong, Leopoldine¹, Walker, Sarah², Jeggo, Penny², Lobrich, Markus^*,1, ¹ Biophysics Department, Homburg, Saar, Germany² Genome Damage and Stability Centre, East Sussex, BN, UK
(MS001) ATM-dependent double-strand break repair and checkpoint functions co-operate to maintain chromosomal stability after ionizing irradiation.

Lu, Hua-Rui¹, Wang, Ya¹, ¹ Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, philadelphia, PA, USA
(MS002) CHK1 interacts with PARP1 to respond to ionizing radiation-induced DNA damage.

Datta, Kamal^*,1, Neumann, Ronald¹, Winters, Thomas¹, ¹ Nuclear Medicine Department/ Warren Grant Magnuson Clinical Center, Bethesda, MD
(MS003) Upstream lesions are a more severe impediment to non-homologous end joining than blocked 3′-ends.

Zhang, Ying^*,1, Lim, Chang¹, Williams, Eli¹, Zhou, Junqing¹, Zhang, Qinming¹, Fox, Michael¹, Bailey, Susan ¹, Liber, Howard¹, ¹ Department of Environmental and Radiological Science, Ft. Collins, CO, USA
(MS004) NBS1 knockdown increases telomere association and radiation mutagenesis in human cells.

Uematsu, Naoya^*,1, Yajima, Hirohiko^*,1, Chen, Benjamin¹, Chen, David¹, ¹ Division of Molecular Radiation Biology, Department of Dadiation Oncology, Dallas, TX, US
(MS005) Live cell imaging of DNA-PK activation and localization at DSB sites induced by microbeam-laser irradiation.

Koturbash, Igor¹, Pogribny, Igor², Stevenson, Sandie¹, Kovalchuk, Olga^*,1, ¹ Department of Biological Sciences, Lethbridge, AB, Canada² Division of Biochemical Toxicology, Jefferson, AR, USA
(MS006) Chronic low dose radiation exposure profoundly alters DNA and histone methylation in murine thymus.

Han, Jianxun^*,1, Hendzel, Michael^{1, 2}, Turner, Joan^{1, 2}, ¹ Department of Oncology, Edmonton, Alberta, Canada² Division of Experimental Oncology, Edmonton, Alberta, Canada
(MS007) Extensive and asynchronous H2AX phosphorylation after ionizing irradiation.

Physico Chemical Events

Cai, Zhongli^*,1, Cloutier, Pierre ¹, Hunting , Darel ¹, Sanche, Leon ¹, ¹ Department of Nuclear Medicine and Radiobiology, Sherbrooke, Quebec, Canada
(MS008) DNA damage induced by low energy electrons and soft X-rays in air as a function of DNA hydration levels.

Roginskaya, Marina^*,1, Razskazovskiy, Yuriy², Bernhard, William¹, ¹ Department of Biochemistry and Biophysics, Rochester, NY, USA² Department of Physics, Johnson City, TN, USA
(MS009) 2'-Deoxyribonolactones are major lesions in DNA exposed to the direct effect of ionizing radiation.

Adhikary, Amitava^*,1, Pazdro, Robert ¹, Malkhasian, Aramice ^{1, 2}, Collins, Sean¹, Becker , David ^*,1, Sevilla, Michael^*,1, ¹ Department of Chemistry, Rochester, Mi, USA² Department of Chemistry, East Lansing, Mi, USA
(MS010) Photo-excitation of guanine radical cation in the near UV-VIS produces sugar radicals in DNA.

Purkayastha, Shubhadeep^*,1, Milligan, Jamie², Bernhard, William¹, ¹ Department of Biochemistry & Biophysics, Rochester, New York, United States² Department of Radiology, La Jolla, California, United States
(MS011) The effects of hydration on strand break formation due to direct ionization of plasmid DNA.

Hada, Megumi^{*,1, 2}, Sutherland, Betsy³, ¹ Division of Space Life Science, Houston, TX, USA² Radiation Biology, Houston, TX, USA³ Biology Department, Upton, NY, USA
(MS012) Clustered DNA damages induced by high LET ionizing radiation in T7 DNA.

Hill, Mark^*,1, Goodhead, Dudley¹, ¹ Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK
(MS013) Do low energy electrons produce lesions characteristic of high-LET or low-LET radiation?

Swartz, Harold^*,1, Iwasaki, Akinori¹, Walczak, Tadeusz¹, Demidenko, Eugene¹, Salikhov, Ildar¹, Romanyukha, Alex², Schauer, David², Starewicz, Piotr³, ¹ EPR Center for the Study of Viable Systems, Hanover, NH, USA² Dept. of Radiology & Radiological Sciences, Bethesda, MD, USA³ Resonance Research, Inc., Billerica, MA, USA
(MS014) Method to measure clinically significant exposures to ionizing radiation.

Experimental Therapeutics: Normal Tissue Response

Peschke, Peter^*,1, Karger, Christian ¹, Scholz, Michael², Sanchez-Brandelik, Rita¹, Huber, Peter^{1, 3}, Debus, Jürgen^{1, 3}, ¹ Dept. of Radiotherapy, 69120-Heidelberg, Germany, Germany² Dept. of Biophysics, Darmstadt, Germany, Germany³ Dept. of Clinical Radiology, Heidelberg, Germany, Germany
(MS015) Radiation-induced myelitis in the spinal cord of rats after single and split doses of photons and carbon ions.

Hamstra, Daniel^{*,1, 3}, Griffin, Laura^{1, 4}, Bhojani, Swaroop^{1, 4}, Ross, Brian^{2, 3, 4}, Rehemtulla, Alnawaz^{1, 2, 4}, ¹ Departments of Radiation Oncology, Ann Arbor, MI³ Department of Biochemistry, Ann Arbor, MI⁴ The Center for Molecular Imaging, Ann Arbor, MI² Department of Radiology, Ann Arbor, MI
(MS016) Non-invasive real time imaging of the oscillatory pattern of p53 dependent gene activation following chemoradiotherapy.

Fehrmann, Astrid¹, Doerr, Wolfgang^{*,1, 2}, ¹ Radiobiology Laboratory, Dresden, Saxony, Germany² Experimental Center, Dresden, Saxony, Germany
(MS017) Modulation of radiation-induced oral mucositis (mouse) by EGFR-inhibition.

Mendonca, Marc^{*,1, 2}, Chin-Sinex, Helen¹, Mead, Laura³, Yoder, Merv³, Ingram, David³, ¹ Radiation Oncology / Radiation and Cancer Biology Labs, Indianapolis, IN, USA² Medical and Molecular Genetics, Indianapolis, IN, USA³ Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, IN, USA
(MS018) Endothelial stem/progenitor cells are X-ray sensitive with limited repair capacity.

Cohen, Eric¹, Fish, Brian², Moulder, John^*,2, ¹ Medicine, Milwaukee, WI, USA² Radiation Oncology, Milwaukee, WI, USA
(MS019) Angiotensin II type-2 (AT2) receptor blockade in experimental radiation nephropathy.

Hopewell, John^*,1, Millar, William², ¹ Department of Clinical Oncology, Oxford, Oxon, UK² Department of Radiation Oncology, Glasgow, Strathclyde, UK
(MS020) Effects of low dose-rate ⁹⁰Sr/⁹⁰Y exposure on the acute moist desquamtion response of pig skin.

Wang, Junru^*,1, Qiu, Xiaohua¹, Kulkarni, Ashwini¹, Hauer-Jensen, Martin¹, ¹ Arkansas Cancer Research Center, Little Rock, AR
(MS021) Regulation of the acute intestinal radiation response by calcitonin gene-related peptide (CGRP) and substance P (SP).

RRS/ASTRO Minisymposium on Mechanisms of DNA Repair

Sun, Yingli^*,1, Price, Brendan¹, ¹ Radiation Oncology, Boston, MA, USA
(MS022) Tip60 Histone Acetyltransferase regulates the acetyaltion and activation of ATM following DNA damage.

McCann, Kelly^*,1, Spikacova, Tatiana^*,1, Game, John², Brown, J. Martin¹, ¹ Department of Radiation Oncology, Stanford, CA, USA² Life Sciences Division, Berkeley, CA, USA
(MS023) DNA repair response requires chromatin remodeling through histone modification.

Kachnic, Lisa^*,1, Willers, Henning¹, Li, Li¹, Treszezamsky, Alejandro¹, Powell, Simon^{1, 2}, ¹ Department of Radiation Oncology, Boston, MA, USA² Department of Radiation Oncology, St. Louis, MO, USA
(MS024) Differential sensitivity of FancA- and FancD2-deficient cells to complex DNA double strand damage.

Hinz, John^*,1, Tebbs, Robert¹, Urbin, Salustra¹, Nham, Peter¹, Salazar, Edmund¹, Kopf, Vicki¹, Yamada, N.¹, Thompson, Larry¹, ¹ Biosciences Directorate, Livermore, CA, USA
(MS025) Role of Rad51 paralogs in genomic stability and resistance to DNA damage.

Tran, Phuoc^*,1, Chen, Y¹, Koong, A.¹, Fey, J.², Liskay, R.², Gellon, L.³, Boiteux, S.³, ¹ Stanford Hospital, Stanford, CA, United States² Oregon Health & Science Univ., Portland, OR, United States³ CEA, Fontenay, France
(000) A Mutation in EXO1 Defines Separable Roles in DNA Mismatch Repair and a DNA Mismatch Repairindependent.

Gene, L.¹, Shinohara, E.¹, Hallahan, Dennis^*,1, ¹ Vanderbilt Univ., Nashville, TN, United States
(000) DNA-dependent protein kinase is a molecular target for the development of non-cytotoxic radiation sensitizing drugs.

Glazer, Peter^*,1, Bindra, R.¹, ¹ Yale Univ., New Haven, CT, United States
(000) Dysregulation of Brca1 in hypoxia.

RRS-ASTRO Minisymposium on Radiation-Induced Signaling

Kirshner, Julia^*,1, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer Biology/Life Sciences, Berkeley, CA
(MS026) TGF1 signaling mediates ATM and its downstream target activation in response to ionizing radiation.

Weidhaas, Joanne^*,1, Eisenmann, David¹, ¹ Therapeutic Radiology, New Haven, CT
(MS027) A C. elegans model of EGFR-mediated treatment resistance to cytotoxic therapy.

Semenenko, Vladimir^*,1, Dong, Shaozhong¹, Fan, Ming¹, Ahmed, Kazi¹, Li, Jian Jian ¹, ¹ Divisioin of Moledcular Radiobiology, West Lafayette, Indiana, USA
(MS028) NF-kappaB Mediated Signaling Network in the Radioresistance of Human Breast Cancer Cells.

Garg, Madhur^*,1, Shah, S.J.¹, Deb, N.J.¹, Liu, L.¹, Guha, C.¹, ¹ Montefiore Medical Center, Bronx, NY, United States
(000) Targeting the Tie2 receptor tyrosine kinase pathway for radiosensitization of prostate cancer.

Schneider, Robert^*,1, Braunstein, S.¹, Xi, Q.¹, Formenti, S.², ¹ NYU School of Medicine, New York, NY, United States² NYU School of Medicine, New York, NY, United States
(000) Ionizing radiation controls protein synthesis through a novel akt-independent pathway involving regulation.

Gupta, Anjali^*,1, Cerniglia, G.J.¹, McKenna, W. Gilles¹, Mick, R.², Muschel, R.J.³, ¹ Univ. of Pennsylvania, Philadelphia, PA, United States² Univ. of Pennyslvania, Philadelphia, PA, United States³ Children's Hospital of Philadelphia, Philadelphia, PA, United States
(000) Down-regulation of akt signaling with HIV-1 protease inhibitors.

Mutagenesis & Carcinogenesis

Ramaiah, Lila^*,1, Weil, Michael², Desaintes, Christian³, Ullrich, Robert², ¹ Department of Microbiology, Immunology, & Pathology, Fort Collins, CO, USA² Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA³ Radiobiology Unit, Boeretang, Mol, Belgium
(MS029) Dissecting the role of Prkdc^BALB polymorphisms in radiation-induced mammary cancer.

Dudgeon, Crissy ¹, Li, Henghong^*,2, Bulavin, Dmitry ³, Fornace, Albert ¹, ¹ Dept. of Genetics and Complex Diseases, Boston, MA, US² Center for Cancer Research, Bethesda, MD, US³
(MS030) Characterization of -radiation induced tumorigenesis with a humanized-p53 mouse model.

Loucas, Bradford^*,1, Cornforth, Michael¹, ¹ Department of Radiation Oncology, Galveston, TX, USA
(MS031) Are un-rejoined chromosome breaks always the result of an irreparable lesion?

Elmore, Eugene^*,1, Lao, Xiao-Yan¹, Ko, Micki¹, Kapadia, Rubina¹, Rightnar, Steven², Nelson, Gregory², Redpath, Les ¹, ¹ Radiation Oncology, Irvine, CA, USA² Loma Linda University Proton Therapy Facility, Loma Linda, CA, USA
(MS032) Neoplastic transformation in vitro induced by low doses of 232 MeV protons.

Zhang, Qinming^*,1, LIU, YUNFENG², ZHOU, JUNQING¹, ZHANG, YING¹, LIBER, HOWARD^*,1, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Graduate Degree Program in Cell and Molecular Biology, Fort Collins, CO, USA
(MS033) Wild-type p53 has dominant effects over mutant p53 to maintain genomic stability in human lymphoblast cell.

LaRue, Susan^*,1, Trncic, Nadira ¹, Holmes, Adam², Vanais, Diane³, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, Colorado, USA² Cell & Molecular Biology Graduate Program, Fort Collins, Colorado, USA³ Radiation Effects Research Foundation, Hiroshima City, Japan, Japan
(MS034) Severe tumor hypoxia induces mutagenesis.

Burns, Fredric^*,1, Zhang, Ronghe¹, Chen, Shuaili¹, Uddin, Ahmed¹, Wu, Feng, ¹ Environmental Medicine, New York, NY, USA
(MS035) Comparison of gene expression in rat skin following comparable doses of electron or 56Fe ion radiation.

Radiation Signaling in Normal Tissues

Zhao, Weiling^*,1, Kooshki, Mitra¹, Payne, Valerie¹, Robbins, Mike ¹, ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC, USA
(MS036) Transthyretin, a cellular defense gene expressed in traumatic brain injury and Alzheimer′s disease, is upregulated 6 months after brain irradiation.

Boerma, Marjan^*,1, Kennedy, Richard², Kulkarni, Ashwini¹, Joseph, Jacob³, Wondergem, Jan⁴, Wang, Junru¹, Hauer-Jensen, Martin¹, ¹ Departments of Surgery and Pathology, Little Rock, AR, USA² Loyola University Medical Center, Maywood, IL, USA³ Cardiology Section, West Roxbury, MA, USA⁴ Leiden University Medical Center, Leiden, NL, The Netherlands
(MS037) Interactions between mast cells and the endothelin system in radiation-induced heart disease.

Worgul, Basil^*,1, Kleiman, Norman², David, Janice¹, ¹ Eye Radiation & Environmental Reseach, Dept. Ophthalmology, New York, NY, US² Environmental Health Sciences, New York, NY, US
(MS038) A positive and negative bystander effect influences cataractogenesis in lenses exposed to low doses of x-rays.

Williams, Jacqueline^*,1, Hernady, Eric¹, Johnston, Carl², Reed, Christina², Finkelstein, Jacob², ¹ Radiation Oncology, Rochester, NY, USA² Pediatrics/Neonatology, Rochester, NY, USA
(MS039) An investigation into the relationship between IL-1, IL-1, MCP-1, and radiation late effects in the lung.

Schuller, Bradley^*,1, Ma, Ling², Hawthorne, Frederick², Binns, Peter³, Riley, Kent ³, Coderre, Jeffrey ¹, ¹ Department of Nuclear Science and Engineering, Cambridge, MA, USA² Department of Chemistry and Biochemistry, Los Angeles, CA, USA³ Nuclear Reactor Laboratory, Cambridge, MA, USA
(MS040) Selective irradiation of the vascular endothelium.

Milliat, Fabien^{*,1, 2}, François, Agnès^{*,1, 2}, Isoir, Muriel^*,1, Sabourin, Jean-Christophe^*,3, Benderitter, Marc ^*,1, ¹ Laboratory of Radiopatholgy, Fontenay aux Roses, France² UPRES EA2710 Radiosensitivity of tumor and normal tissues, Villejuif, France³ Department of Pathology, Villejuif, France
(MS041) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation.

Greenberger, Joel^*,1, Zhang, Xichen¹, Hricisak, Lauren¹, Epperly, Michael¹, ¹ Radiation Oncology/Medicine, Pittsburgh, PA, USA
(MS042) Absence of the Smad3 gene product increases radiation resistance of bone marrow stromal cells.

Low Dose Risks and Modeling

Wroe, Andrew^*,1, Rosenfeld, Anatoly¹, Schulte, Reinhard², Cornelius, Iwan¹, ¹ Centre for Medical Radiation Physics, Wollongong, NSW, Australia² Department of Radiation Medicine, Loma Linda, CA, USA
(MS043) Preliminary investigation of microdosimetric spectra within heterogeneous structures.

Ostrovskaya, Natela¹, Ford, John^*,1, ¹ Department of Nuclear Engineering, College Station, TX, U.S.
(MS044) Modeling of tissue kinetics and radiation response to the epithelial layer of human bronchiole.

de Toledo, Sonia^*,1, Asaad, Nesrin¹, Venkatachalam, Perumal¹, Li, Ling², Howell, Roger¹, Spitz, Douglas², Azzam, Edouard¹, ¹ Department of Radiology/Division of Radiation Research, Newark, NJ, USA² Department of Radiation Oncology/Holden Comprehensive Cancer Center, Iowa City, IA, USA
(MS045) Mechanisms underlying ionizing radiation induced adaptive responses in normal human cells grown in three-dimensional architecture.

Ratnayake, Ruwan^*,1, Stewart, Robert², ¹ School of Health Science, West Lafayette, IN, USA² School of Health Science, West Lafayette, IN, USA
(MS046) Analysis of medium transfer, microbeam and broad parallel beam experiments using intercellular signaling models.

Hattis, Dale¹, Russ, Abel¹, Ericson, Jennifer¹, Cox, Catherine¹, Langlois, Ann¹, Parakh, Seema¹, Seth, Divya¹, Goble, Robert^*,1, ¹ George Perkins Marsh Institute, Worcester, MA, USA
(MS047) Tales from the crypt: hierarchical modeling of genomic defense mechanisms related to radiation-induced cancers.

Neriishi, Kazuo^*,1, Nakashima, Eiji², Fujiwara, Saeko¹, ¹ Department of Clinical Studies, Hiroshima, Japan, Japan² Department of Statistics, Hiroshima, Japan, Japan
(MS048) Postoperative cataract in atomic-bomb survivors; Dose response relationship, indirect effect factors and threshold.

ASTRO/RRS Joint Sessions

ASTRO/RRS Panels

The Importance of Hypoxia in Radiobiology and Radiotherapy

Molecular Targeting in RT-EGFR and Beyond

⁴

Update of Normal Tissue Radiobiology in the IMRT Era

⁴

⁵

⁴

⁵

⁴

ASTRO/RRS Mini-Symposia

Hypoxia and Vasculature

Protection of Normal Tissues

Molecular Signaling

Poster Discussion Sessions

Poster Discussion on Radiation Signaling and the Cell Cycle

Sitko, John^*,1, McBride, William¹, ¹ Radiation Oncology, Los Angeles, CA, USA
(PD001) Suppressors of Cytokine Signaling as Modulators of Radiation Response.

Plesca, Dragos^{*,1, 2}, Mazumder, Suparna¹, Almasan, Alex^{1, 2, 3}, ¹ Department of Cancer Biology, Cleveland, OH, USA² School of Biomedical Sciences, Kent, OH, USA³ Department of Radiation Oncology, Cleveland, OH
(PD002) The interaction of the proteolytic fragment of Cyclin E with Ku70 enhances apoptosis by inhibiting DNA repair.

Seo, Haeng-Ran¹, Lee, Dae-Hoon ¹, Bae, Sangwoo ¹, Soh, Jae-Won ², Lee, Yun-Sil ¹, ¹ Laboratory of Radiation Effect, Seoul, Nowon-Ku, Korea² Laboratory of Signal Transduction,Department of Chemistry, Incheon, Nam-Ku, Korea
(PD003) Cyclin G1 Facilitates Radiation-Induced G2-M Transition and Cell death through Transcriptional Activation of Cyclin B1.

Crosby, Meredith ^{*,1, 2}, Jacobberger, James¹, Macklis, Roger ³, Almasan, Alexandru^{2, 3}, ¹ Department of Environmental Health Sciences, Cleveland, OH, USA² Department of Cancer Biology, Cleveland, OH, USA³ Department of Radiation Oncology, Cleveland, OH, USA
(PD004) E2F4/p130 complexes serve as critical regulators of the ionizing radiation-induced G2 cell cycle arrest.

Fisher, Carolyn^*,1, Goswami, Prahbat¹, ¹ Free Radical and Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA, USA
(PD005) Increased radioresistance and G2 delay in manganese superoxide dismutase overexpressing human pancreatic cancer cells.

Natarajan, Mohan ¹, Nallathamby, Prakash², Xu, Nancy², ¹ Department of Radiation Oncology, San Antonio, Texas, USA² Department of Chemistry and Biochemistry, Norfolk, VA, USA
(PD006) Molecular imaging of TNF-a trafficking from irradiated to un-irradiated cells using silver (Ag) nanoprobes.

Andarawewa, Kumari ^*,1, Erickson, Anna ¹, Chou, William ¹, Bissell , Mina ¹, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer biology, berkeley, CA, USA
(PD007) Ionizing Radiation Predisposes Human Mammary Epithelial Cells to TGF induced Epithelial to Mesenchymal Transition.

Guo, Chang ^*,1, Brautigan, David², Larner, James^*,1, ¹ Dept. of Radiation Oncology, Charlottesville, VA, USA² Center for Cell Signaling, Charlottesville, VA, USA
(PD008) IR Inhibits Centrosome Separation Through Nek2 and PP1.

Khodarev, Nikolai^*,1, Labay, Edwardine¹, Darga, Thomas, Beckett, Michael¹, Mauceri, Helena ¹, Halpern, Arielle¹, Bickenbach, Kai ², Veerapong, Jula², Schmidt, P. Henry², Bernard, Roizman³, Weichselbaum, Ralph¹, ¹ Department of Radiation and Cellular Oncology, Chicago, IL, USA² Department of Surgery, Chicago, IL, USA³ Marjorie B. Kovler Viral Oncology Laboratories, Chicago, IL, USA
(PD009) Stat1 dependent pathway as a mediator of tumor response to ionizing radiation and integrator of ionizing radiation and interferon induced pathways.

Experimental Therapeutics Poster Discusson on Tumor Targeting

Milas, Luka¹, Koto, Masashi^*,1, Valdecanas, David¹, Mason, Kathy¹, Hunter, Nancy¹, Fan, Zhen², Fang, Fu-Min¹, Ang, Kian³, ¹ Experimental Radiation Oncology and Division of Radiation Oncology, Houston, TX, USA² Experimental Therapeutics, Houston, TX, USA³ Division of Radiation Oncology, Houston, TX, USA
(PD010) C225-induced enhancement of tumor radioresponse: Influence of timing of C225 administration.

Cowen, Rachel¹, Wind, Natasha¹, Telfer, Brian¹, Stratford, Ian¹, Papadopoulou, Maria^*,2, Bloomer, William², Williams, Kaye¹, ¹ School of Pharmacy and Pharmaceutical Sciences, Manchester, Greater Manchester, UK² Department of Radiation Medicine, Evanston, Illinois, USA
(PD011) Exploiting cytochrome p450 reductase-mediated enhancement of NLCQ-1 hypoxic cytotoxicity for use in combination with radiotherapy.

Moeller, Benjamin^*,1, Dreher, Matthew², Rabbani, Zahid³, Schroeder, Thies³, Cao, Yiting¹, Dewhirst, Mark^{1, 2, 3}, ¹ Department of Pathology, Durham, NC, USA² Department of Biomedical Engineering, Durham, NC, USA³ Department of Radiation Oncology, Durham, NC, USA
(PD012) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

Ponce, Ana^*,1, Viglianti, Benjamin¹, Yarmolenko, Pavel², Bally, Marcel³, Woo, Janet³, Dewhirst, Mark², ¹ Dept of Biomedical Engineering, Durham, NC² Dept of Radiation Oncology, Durham, NC³ BC Cancer Agency, Vancouver, BC
(PD013) Liposomal drug distribution and anti-tumor effect: drug dose painting with hyperthermia using MRI.

Wiedenmann, Nicole^{*,1, 2}, Neal, Robert¹, Hunter, Nancy¹, Raju, Uma¹, Milas, Luka¹, Mason, Kathy¹, ¹ Department of Experimental Radiation Oncology, Houston, TX, USA² Department of Radiation Oncology, Munich, D, Germany
(PD014) In vivo interaction of single dose radiation with G3139, a Bcl-2 antisense oligonucleotide.

Xu, Mai¹, Wu, M², Crooks, Peter³, Freeman, Michael⁴, Roti Roti, Joseph^*,1, ¹ Radiation and Cancer Biology Division, St. Louis, MO, USA² Department of Radiation Oncology, Taipei, Taiwan, China³ College of Pharmacy, Lexington, KY, USA⁴ Department of Radiation Oncology, Nashville, TN
(PD015) Radiosensitization by the combination of 41°C hyperthermia and indomethacin analogs.

Burd, Randy ^*,1, Lavorgna, Stephanie ¹, Thangasamy, Thilakavathy¹, Kong, Xianguo¹, Lenaz, Luigi ², Chawla, Shanta², Reddy, Guru², Wachsberger, Phylis ¹, Dicker, Adam¹, ¹ Radiation Oncology, Philadelphia, PA, USA² Oncology, Irvine, CA, USA
(PD016) Enhancement of radiation response in tumors by the bioreductive agent Apaziquone (EO9, EOquin).

Krause, Mechthild^*,1, Ostermann, Gernot¹, Petersen, Cordula¹, Harstrick, Andreas², Yaromina, Ala¹, Thames, Howard³, Baumann, Michael¹, ¹ Dept. of Radiation Oncology, Dresden, Saxony, Germany² Merck KG aA, Darmstadt, Hessen, Germany³ Dept. of Biomathematics, Houston, Texas, USA
(PD017) Targeting of the EGFR by C225 improves local control of FaDu hSCC by decreased repopulation and increased reoxygenation during fractionated irradiation.

Poster Discussion on Genomic Damage and Repair

Chan, Norman^*,1, Meng, Alice¹, Jalali, Farid¹, Bindra, Ranjit², Glazer, Peter², Powell, Simon³, Bristow, Rob¹, ¹ Department of Medical Biophysics, Toronto, Ontario, Canada² Department of Therapeutic Radiology, New Haven, CT, USA³ Department of Radiation Oncology, St. Louis, MO, USA
(PD018) DNA double strand break repair and hypoxia-mediated genetic instability.

Bindra, Ranjit^{*,1, 2}, Gibson, Shannon^{1, 7}, Meng, Alice^{5, 6}, Jasin, Maria ³, Pierce, Andrew⁴, Bristow, Robert^{5, 6}, Classon, Marie⁷, Glazer, Peter^{1, 8}, ¹ Department of Therapeutic Radiology, New Haven, CT, USA² Department of Experimental Pathology, New Haven, CT, USA⁷ MGH Cancer Center, Charlestown, MA, USA⁵ Ontario Cancer Institute, Toronto, Ontario, Canada⁶ Department of Medical Biophysics, Toronto, Ontario, Canada³ Molecular Biology Program, New York, NY, USA⁴ Department of Microbiology, Immunology and Molecular Genetics, Lexington, KY, USA⁸ Department of Genetics, New Haven, CT, USA
(PD019) Stress-induced regulation of BRCA1 expression by E2Fs.

Byrne, Shaun¹, Bellon, Sophie¹, Lomax, Martine¹, O'Neill, Peter^*,1, ¹ DNA Damage Group, Harwell, Oxon, UK
(PD020) Clustered damage: 5,6-dihydrothymine retards base excision repair of an AP site by xrs5 nuclear extracts.

Gibbons, Catherine^{*,1, 2}, Natarajan, Mohan³, Mohan, Sumathy⁴, Pandeswara, S³, Moore, Stephen¹, Grosovsky, Andrew², Kadhim, Munira¹, ¹ Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK² Environmental Toxicology Graduate Program, Riverside, CA, USA³ Department of Radiation Oncology, San Antonio, TX, USA⁴ Department of Pathology, San Antonio, TX, USA
(PD021) TNF as a potential signaling mediator of genomic instability and the bystander effect.

George, Kerry^{*,1, 3}, Durante, Marco ², Cucinotta, Francis³, ¹ Wyle Laboratories, Houston, TX, USA³ NASA, Lyndon B. Johnson Space Center, Houston, TX, USA² University Federico II, Naples, Italy
(PD022) Chromosome aberrations in the progeny of human lymphocytes exposed to energetic heavy ions.

Lee, Kyung-Jong ^*,1, Yajima, Hirohiko¹, Qin, Jun², Chen, Benjamin¹, Chen, David¹, ¹ Division of Molecular Radiation Biology, Department of Radiation Oncology, Dallas, TX, USA² Department of Molecular and Cellular Biology, Houston, TX, USA
(PD023) Implication of interaction between catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and BRCA1.

Bahary, Nathan^*,2, Epperly, Michael¹, Quadar, Mubina¹, Greenberger, Joel¹, ² Molecular Genetics and Biochemistry, Pittsburgh, PA, USA¹ Radiation Oncology, Pittsburgh, PA, USA
(PD024) Small molecule antioxidants prevent ionizing irradiation-induced fibrosis in the adult zebrafish.

Meng, Xiangbing^*,1, Shen, Zhiyuan¹, ¹ Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PD025) Knockdown of BCCIP impairs p53-transactivation activity in response to irradiation.

Poster Sessions

Physico-Chemical Events

Ashburn, John ^*,1, Cui, Nuan¹, Fettinger, Michael¹, Mohiuddin, Mohammed¹, Ahmed, Mansoor¹, ¹ Radiation Medicine and Radiation Biology Department, Lexington, KY, USA
(PP001) Comparative response of cancer cells to pulsed magnetic fields in the .1 - 5 tesla range.

Balagurumoorthy, Pichumani^*,1, Chen, Kai¹, Bash, Ralph², Adelstein, S. James¹, Kassis, Amin¹, ¹ Department of Radiology, Boston, MA, USA² The Biodesign Institute, Tempe, AZ, USA
(PP002) Linear DNA has greater susceptibility than supercoiled DNA to double-strand breaks caused by Auger electrons.

Balagurumoorthy, Pichumani^*,1, Chen, Kai¹, Adelstein, S. James¹, Kassis, Amin¹, ¹ Department of Radiology, Boston, MA, USA
(PP003) DNA strand breaks in supercoiled DNA after decay of ¹²³I-labeled Hoechst 33342.

Balagurumoorthy, Pichumani^*,1, Chen, Kai¹, Bash, Ralph², Adelstein, S. James¹, Kassis, Amin¹, ¹ Department of Radiology, Boston, MA, USA² The Biodesign Institute, Tempe, AZ, USA
(PP004) Insight into the mechanisms leading to the production of double-strand breaks in supercoiled DNA by ¹²⁵I-Hoechst.

Rayadurgam, Sripriya ¹, Liu, Haifeng ¹, Wang, Xudong ¹, Xia, Zhenghua¹, Braby, Leslie^*,1, ¹ Nuclear Engineering, College Station, Texas, USA
(PP005) Microdosimetry for two site sizes.

Cai, Zhongli^*,1, Cloutier, Pierre ¹, Hunting , Darel ¹, Sanche, Leon ¹, ¹ Department of Nuclear Medicine and Radiobiology, Sherbrooke, Quebec, Canada
(PP006) DNA damage induced by low energy electrons and soft X-rays in air as a function of DNA hydration levels.

Cardenas-Navia, Laura^*,1, Dewhirst, Mark², ¹ Biomedical Engineering, Durham, NC, USA² Radiation Oncology, Durham, NC, USA
(PP007) Fluctuating oxygen in tumors alters tirapazamine pharmacodynamics.

Dingfelder, Michael^*,1, Jorjishvili, Irakli¹, Gersh, Jacob¹, Toburen, Larry¹, ¹ Department of Physics, Greenville, NC, USA
(PP008) Track structure simulations of relativistic heavy charged particles.

Gersh, Jacob^*,1, Dingfelder, Michael¹, Toburen, Larry¹, ¹ Department of Physics, Greenville, NC, USA
(PP009) Interface-induced dose perturbation in trabecular bone - a Monte Carlo approach.

Grygoryev, Dmytro^*,1, Zimbrick, John¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP010) Release of unaltered bases in irradiated aqueous solutions of purines and pyrimidines.

Hada, Megumi^{*,1, 2}, Sutherland, Betsy³, ¹ Division of Space Life Science, Houston, TX, USA² Radiation Biology, Houston, TX, USA³ Biology Department, Upton, NY, USA
(PP011) Clustered DNA damages induced by high LET ionizing radiation in T7 DNA.

Hill, Mark^*,1, Goodhead, Dudley¹, ¹ Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK
(PP012) Do low energy electrons produce lesions characteristic of high-LET or low-LET radiation?

Hiz, Zekiye^*,,
(PP013) Radiation reveals the biological structure-function relationships.

Kan, Chu-Cheng^*,1, Koon, Shirley¹, Shah, Shetal¹, Sood, Brij ¹, Li, Gloria², Nori, Dattatreyudu¹, ¹ Radiation Oncology/Randazzo Cell Biology Laboratory, Flushing, NY, USA² Medical Physics/hyperthermia and radiation biology laboratory, New York, NY
(PP014) The effect of statins on LNCaP prostate cancer cells and U87MG glioblastoma cells.

Meade, Aidan^{*,1, 3}, Byrne, Hugh², Lyng, Fiona^{2, 3}, ¹ School of Physics, Dublin, Dublin 8, Ireland³ Radiation and Environmental Science Centre (RESC), Dublin, Dublin 8, Ireland² FOCAS Institute, Dublin, Dublin 8, Ireland
(PP015) Vibrational spectroscopy and radiobiological assays of HaCaT keratinocytes post exposure to ionising radiation.

Ly, Anne¹, Tran, Nancy¹, Milligan, Jamie^*,1, ¹ Department of Radiology, La Jolla, CA
(PP016) Mechanism of guanine oxidation by the methylperoxyl radical.

Emfietzoglou, Dimitris , Cucinotta, Francis, Nikjoo, Hooshang^*,,
(PP017) A complete dielectric response model for liquid water: a solution of the Bethe Ridge problem.

Uehara, Shuzo¹, Nikjoo, Hooshang^*,2, ¹ School of Health Sciences, Fukuoka, Fukuoka Prefecture, Japan² Center for Advanced Space Studies, USRA, Houston, Texas, USA
(PP018) Monte Carlo simulation of water radiolysis for low-energy charged particles.

Pasciak, Alexander¹, ¹ Department of Nuclear Engineering, College Station, TX
(PP019) Ultra-high speed Monte Carlo computing using field programmable gate arrays.

Purkayastha, Shubhadeep^*,1, Milligan, Jamie², Bernhard, William¹, ¹ Department of Biochemistry & Biophysics, Rochester, New York, United States² Department of Radiology, La Jolla, California, United States
(PP020) The effects of hydration on strand break formation due to direct ionization of plasmid DNA.

Richardson, Rachel^*,1, Gamcsik, Michael², Biaglow, John³, Dewhirst, Mark, ¹ Radiation Oncology, Durham, NC, USA² Medicine, Durham, NC, USA³ Radiation Oncology, Philadelphia, PA, USA
(PP021) Lactate consumption by the rat R3230 mammary adenocarcinoma.

Roginskaya, Marina^*,1, Razskazovskiy, Yuriy², Bernhard, William¹, ¹ Department of Biochemistry and Biophysics, Rochester, NY, USA² Department of Physics, Johnson City, TN, USA
(PP022) 2'-Deoxyribonolactones are major lesions in DNA exposed to the direct effect of ionizing radiation.

Pan, Xiaoning¹, Sanche, Léon^*,1, ¹ Department of Nuclear Medicine and Radiobiology, Sherbrooke, Quebec, Canada
(PP023) Direct damage to DNA by low-energy electrons.

Schulte, Reinhard^*,1, Bashkirov, Vladimir¹, Schulte, Birgit¹, Milligan, Jamie², ¹ Radiation Medicine, Loma Linda, CA, USA² Radiology, La Jolla, CA, USA
(PP024) Complex lesion yields in plasmid DNA produced by protons in the therapeutic energy range.

Sellami, Lamia^*,1, Deng, Zongwu¹, Huels, Michael¹, ¹ Dept. of Nuclear Medicine and Radiobiology, Faculty of Medicine, Sherbrooke, Quebec, Canada
(PP025) Radiation damage to DNA components induced by hyperthermal heavy ions.

Adhikary, Amitava^*,1, Pazdro, Robert ¹, Malkhasian, Aramice ^{1, 2}, Collins, Sean¹, Becker , David ^*,1, Sevilla, Michael^*,1, ¹ Department of Chemistry, Rochester, Mi, USA² Department of Chemistry, East Lansing, Mi, USA
(PP026) Photo-excitation of guanine radical cation in the near UV-VIS produces sugar radicals in DNA.

Sharma, Kiran^*,1, Purkayastha, Shubhadeep¹, Naumenko, Katerina¹, Swarts, Steven¹, Bernhard, William¹, ¹ Biochemistry & Biophysics, Rochester, New York, USA
(PP027) Distribution of products formed by the direct radiation damage to DNA films: the d(CGCGCG)₂ duplex.

Gillard, Nathalie ¹, Begusova, Marie², Castaing, Bertrand¹, Culard, Francoise¹, Spotheim-Maurizot, Melanie ^*,1, ¹ Centre de Biophysique Moleculaire, Orleans, France, France² Department of Radiation Dosimetry, Prague 8, Czech Republic, Czech Republic
(PP028) Radiolysis of DNA-binding proteins : experiment versus calculation.

Swartz, Harold^*,1, Iwasaki, Akinori¹, Walczak, Tadeusz¹, Demidenko, Eugene¹, Salikhov, Ildar¹, Romanyukha, Alex², Schauer, David², Starewicz, Piotr³, ¹ EPR Center for the Study of Viable Systems, Hanover, NH, USA² Dept. of Radiology & Radiological Sciences, Bethesda, MD, USA³ Resonance Research, Inc., Billerica, MA, USA
(PP029) Method to measure clinically significant exposures to ionizing radiation "after-the-fact" suitable for terrorist incidents or accidents.

Zheng, Yi^*,1, Cloutier, Pierre¹, Hunting, Darel ¹, Wagner, Richard¹, Sanche, Léon¹, ¹ Dept. of Nuclear Medicine & Radiobiology/ Canadian Institutes of Health Research Group in the Radiation Sciences, Sherbrooke, Quebec, Canada
(PP030) Electron transfer in DNA by low-energy electrons: effect of a stable abasic site on cleavage in model tetramers.

Risks and Modeling at Low Doses

Ahmed, Kazi^*,1, Fan, Ming¹, Dong, Shaozhong¹, Yu, Cheng-Rong², Spitz, Douglas³, Li, Jian Jian ¹, ¹ Division of Molecular Radiobiology, West Lafayette, Indiana, USA² Laboratory of Immunology, Bethesda, Maryland, USA³ Department of Radiation Oncology, Iowa City, Iowa, USA
(PP031) Adaptive response of mouse skin epithelial cells to low dose ionizing radiation: induction of NF-kappaB, MnSOD, 14-3-3zeta and cyclin B1.

Blake-James, Molly^*,1, Mill, Andrew¹, Hill, Mark², ¹ Radiation Biophysics Group, Birmingham, West Midlands, England² Radiation and Genome Stability Unit, Harwell, Oxon, England
(PP032) Radiation-induced bystander effects in CGL cells for cell killing and neoplastics transformation: implications for radiotherapy.

Cassidy, Cheryl^*,1, Lemon, Jen¹, Boreham, Doug¹, ¹ Medical Physics and Applied Radiation, Hamilton, Ontario, Canada
(PP033) Effects of low-dose gamma-radiation on chromosome damage in non-human biota.

Costes, Sylvain^*,1, Boissiere, Arnaud¹, Rydberg, Bjorn¹, Ravani, Shraddha¹, Romano, Raquel¹, Parvin, Bahram¹, Barcellos-Hoff, Mary Helen¹, ¹ Division of Cancer Biology, Berkeley, CA, USA
(PP034) High-throughput image analysis to model radiation induced nuclear foci.

de Toledo, Sonia^*,1, Asaad, Nesrin¹, Venkatachalam, Perumal¹, Li, Ling², Howell, Roger¹, Spitz, Douglas², Azzam, Edouard¹, ¹ Department of Radiology/Division of Radiation Research, Newark, NJ, USA² Department of Radiation Oncology/Holden Comprehensive Cancer Center, Iowa City, IA, USA
(PP035) Mechanisms underlying ionizing radiation induced adaptive responses in normal human cells grown in three-dimensional architecture.

Ostrovskaya, Natela¹, Ford, John^*,1, ¹ Department of Nuclear Engineering, College Station, TX, U.S.
(PP036) Modeling of tissue kinetics and radiation response to the epithelial layer of human bronchiole.

Goldberg, Zelanna^*,1, Rocke, David², Schwietert, Chad¹, Stern, Robin¹, Lehmann, Joerg¹, Jones, Angela¹, Santana, Alison¹, ¹ Dept. of Radiation Oncology, Sacramento, CA, USA² Division of Biostatistics, Sacramento, CA, USA
(PP037) Transcriptional responses in humans following in vivo exposure to ionizing radiation.

Griffith, William^*,1, DeFrank, Nicole¹, Gohlke, Julia¹, Gribble, Elizabeth¹, Faustman, Elaine¹, ¹ Institute for Risk Analysis and Risk Communication, Seattle, WA, USA
(PP038) Computational model for radiation effects at low doses in the developing neocortex.

Hamilton, Sarah ^*,1, Gridley , Daila ², Pecaut, Michael ², Harris , Lisa ³, Howard , Hunter ¹, Bateman, Ted ¹, ¹ Bioengineering Department, Clemson, SC, USA² Department of Radiation Medicine, Loma Linda, CA, USA³ Southern Illinois University, Springfield, IL, USA
(PP039) Osteoblast and osteoclast response to radiation induced bone loss.

Jacob, Peter ^*,1, Meckbach, Reinhard¹, Romanov, Sergey², Vasilenko, Evgeni³, ¹ Institute of Radiation Protection, Neuherberg, Germany, Germany² ³
(PP040) Lung cancer in Mayak workers: interaction of smoking and plutonium exposure.

Kuhne, Wendy^*,1, Whicker, F.¹, Bedford, Joel¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP041) Transgenerational radiation genetics: low dose-rate effects and adaptive response in Japanese Medaka (Oryzias latipes).

Kulkarni, Rohan^*,1, Thomas, Robert¹, Bailey, Nicole¹, Najib, Asma¹, Bommeneni, Arya¹, Tucker, James¹, ¹ Dept. of Biological Sciences, Detroit, Michigan, USA
(PP042) Transcriptional changes in human b-cells exposed to low-dose ionizing radiation.

Li, Xifeng^*,1, Sanche, Leon¹, Sevilla, Michael², ¹ Département de Médecine Nucléaire et Radiobiologie, Sherbrooke, Quebec, Canada² Chemistry, Rochester, Michigan, USA
(PP043) Low energy electron induced base release in nucleosides: a DFT theoretical study.

Mao, Xiao Wen^*,1, Archambeau, Pierre ¹, Baqai, Waheed¹, Archambeau, John¹, ¹ Radiobiology Program/Radiation Medicine, Loma Linda, CA, USA
(PP044) A quantification study of brain vasculature parameter to proton and iron irradiation using stereology methods.

Meltz, Martin^*,1, ¹ Dept. of Radiation Oncology, San Antonio, TX, USA
(PP045) Radiological Event Preparedness Registry (REPR): A database for radiation experts to assist local terrorism response personnel.

Neriishi, Kazuo^*,1, Nakashima, Eiji², Fujiwara, Saeko¹, ¹ Department of Clinical Studies, Hiroshima, Japan, Japan² Department of Statistics, Hiroshima, Japan, Japan
(PP046) Postoperative cataract in atomic-bomb survivors; Dose response relationship, indirect effect factors and threshold.

Neti, Prasad^*,1, Howell, Roger¹, ¹ Dept. of Radiology, Division of Radiation Research, Newark, New Jersey, US
(PP047) Multicellular dosimetry as an approach to predict the biological response to nonuniform distributions of Po-210.

Okayasu, Ryuichi^*,1, Okada, Maki¹, Okabe, Atsushi¹, Uchihori, Yukio¹, Suzuki, Masao¹, Takahashi, Sentaro, ¹ International Space Radiation Lab., Chiba, Chiba-ken, Japan
(PP048) Extreme low dose rate irradiation with heavy ions induces accelerated senescence in primary human cells .

Ponomarev, Artem^*,1, Nikjoo, Hooshang², Cucinotta, Francis³, ¹ Division of Space Life Sciences, Houston, TX, USA² Center for Advanced Space Studies, Houston, TX, USA³ Johnson Space Center, Houston, TX
(PP049) Are DNA loops and domains important factors determining the distribution of DNA fragment-sizes induced by high-LET radiation?

Ratnayake, Ruwan^*,1, Stewart, Robert², ¹ School of Health Science, West Lafayette, IN, USA² School of Health Science, West Lafayette, IN, USA
(PP050) Analysis of medium transfer, microbeam and broad parallel beam experiments using intercellular signaling models.

Rocke, David^*,1, Goldberg, Zelanna², Schweitert, Chad², Santana, Alison², Jones, Angela², Stern, Robin, Lehmann, Joerg², ¹ Division of Biostatistics, Davis, CA, USA² Department of Radiation Oncology, Davis, CA, USA
(PP051) Fold change does not accurately assess transcriptional change due to radiation exposure.

Ryan, Lorna^*,1, Lavoie, Josee¹, Schnarr, Kara¹, Boreham, Douglas¹, ¹ Medical Physics and Applied Radiation Sciences, Hamilton, Ontario, Canada
(PP052) Evaluation of the adaptive response of human lymphocytes to different radiation qualities using chromosomal aberrations and apoptosis.

Thorleifson, Erika^*,1, Segura, Tamika ², Prud'homme-Lalonde, Louise², Lachapelle, Sylvie², Qutob, Sami¹, Mullins, Dana ², Wilkinson, Diana², ¹ Consumer and Clinical Radiation Protection, Ottawa, ON, Canada² Radiological Analysis and Defence, Ottawa, ON, Canada
(PP053) Comparison of the mitotic indices and dose prediction when using bromodeoxyuridine or cytochalasin B in the dicentric chromosome assay.

Mullins, Dana¹, Prud'homme-Lalonde, Louise¹, Qutob, Sami², Lachapelle, Sylvie¹, Segura, Tamika¹, Thorleifson, Erika², Wilkinson, Diana^*,1, ¹ Department of National Defence, Ottawa, Ontario, Canada² Health Canada, Ottawa, Ontario, Canada
(PP054) CD4⁺ and CD8⁺ T-cell responses to ionizing radiation.

Wroe, Andrew^*,1, Rosenfeld, Anatoly¹, Schulte, Reinhard², Cornelius, Iwan¹, ¹ Centre for Medical Radiation Physics, Wollongong, NSW, Australia² Department of Radiation Medicine, Loma Linda, CA, USA
(PP055) Preliminary investigation of microdosimetric spectra within heterogeneous structures.

Mutagenesis/Clastogenesis/Carcinogenesis

Bacher, Jeff^*,1, Halberg, Richard¹, Megid, Wael¹, Kent, Marijo¹, Prolla, Tom², ¹ Genetic Analysis, Madison, WI, USA² Genetics-Biotechnology Center, Madison, WI, USA
(PP056) A novel biodosimetry method for measuring radiation-induced genetic damage.

Banath, Judit^*,1, MacPhail, Susan¹, Larrivee, Bruno¹, Olive, Peggy¹, ¹ Medical Biophysics Dept., Vancouver, BC, Canada
(PP057) Multicellular resistance and HPRT mutation in the tumor microenvironment.

Brooks, Antone^*,1, ¹ Environmental Science and Regional Planning, Richland, Washington, USA
(PP058) How bad is a dirty bomb? Cellular and carcinogenic effects of internally deposited radioactive materials.

Bryant, Peter^*,1, Campbell, Elaine¹, Comrie, Muriel¹, ¹ Bute Medical School, St Andrews, Fife, Scotland
(PP059) Radiation-induced chromatid breaks: are they formed by errors in chromatid deconcatenation?

Burns, Fredric^*,1, Zhang, Ronghe¹, Chen, Shuaili¹, Uddin, Ahmed¹, Wu, Feng, ¹ Environmental Medicine, New York, NY, USA
(PP060) Comparison of gene expression in rat skin following comparable doses of electron or 56Fe ion radiation.

Eberle, Richard¹, Loucas, Bradford¹, Cornforth, Michael^*,1, ¹ Radiation Oncology/ Biology Division, Galveston, TX, USA
(PP061) Long-term transmissibility of radiation-induced chromosome aberrations in human fibroblasts.

Elmore, Eugene^*,1, Lao, Xiao-Yan¹, Ko, Micki¹, Kapadia, Rubina¹, Rightnar, Steven², Nelson, Gregory², Redpath, Les ¹, ¹ Radiation Oncology, Irvine, CA, USA² Loma Linda University Proton Therapy Facility, Loma Linda, CA, USA
(PP062) Neoplastic transformation in vitro induced by low doses of 232 MeV protons.

Ross, Carley¹, Keysar, Stephen¹, French, C. Tenley², Fox, Michael^{1, 2, 3}, ¹ Cell and Molecular Biology Program, Fort Collins, CO, USA² Cytomation, GTX, Fort Collins, CO, USA³ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP063) Analysis of CD59 mutants in CHO A_L cells by flow cytometry after gamma radiation or EMS treatment.

Girdhani, Swati^*,1, Ahmed, Mansoor ², Mishra, Kaushala¹, ¹ Radiation Biology and Health Sciences Division, Mumbai, Maharashtra, India² Weis Centre for Research, Danville, PA, U.S.A
(PP064) Enhancement of ionizing radaition effects on MCF-7 breast cancer cell line by curcumin.

Hada, Megumi^{*,1, 2}, Desai, Nirav^{2, 3}, Cucinotta, Francis², Gonda, Steve², Wu, Honglu², ¹ Division of Space Life Science, Houston, TX, USA² Human Adaptation and Countermeasures Office, Houston, TX, USA³ Radiation Biology, Houston, TX, USA
(PP065) M-BAND analysis of chromosome aberrations induced by heavy ion radiations in human epithelia cells.

Hubbard, Karen¹, Pogozelski, Wendy², Steinberg, Mark³, Orlow, Irene⁴, Dermody, James⁵, Hill, Helene⁶, ¹ Department of Biology, New York, NY, US² Dpartment of Chemistry, Geneseo, NY, US³ Department of Chemistry, New York, NY, US⁴ Epidemiology and Biostatistics Department, New York, NY, US⁵ Department of Microbiology and Molecular Genetics, Newark, NJ, US⁶ Department of Radiology, Newark, NJ, US
(PP066) Enumeration of total and deleted mitochondria in DNA from human skin adjacent to melanomas.

Ianzini, Fiorenza ^{*,1, 2, 3}, Domann, Frederick², Kosmacek, Elizabeth³, Mackey, Michael ^{1, 3}, ¹ Department of Pathology, Iowa City, IA, USA² Department of Radiaiton Oncology, Iowa City, IA, USA³ Department of Biomedical Engineering, Iowa City, IA, USA
(PP067) Radiation-induced mitotic catastrophe in human glioblastoma U87MG cells transduced with a dominant negative p53 adenovirus construct.

Kronenberg, Amy^*,1, Gauny, Stacey¹, Connolly, Lanelle², Turker, Mitchell², ¹ Biophysics Department, Berkeley, CA, USA² CROET, Portland, Oregon, USA
(PP068) Impact of the tissue microenvironment on cell killing and autosomal mutagenesis in murine epithelial cells exposed to 1 GeV/amu Fe ions.

Lenarczyk, Marek ^*,1, Lasater, Sarah¹, Jordan, Robert ², Schwartz, Jeffrey ², Liber, Howard ¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Department of Radiation Oncology, Seattle, WA, USA
(PP070) Persistent genomic instability induced in human lymphoblastoid cells exposed to —rays.

Dudgeon, Crissy ¹, Li, Henghong^*,2, Bulavin, Dmitry ³, Fornace, Albert ¹, ¹ Dept. of Genetics and Complex Diseases, Boston, MA, US² Center for Cancer Research, Bethesda, MD, US³
(PP071) Characterization of -radiation induced tumorigenesis with a humanized-p53 mouse model.

Zhang, Qinming^*,1, Liu, Yunfeng², Zhou, Junqing¹, Zhang, Ying ¹, Liber, Howard^*,1, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Graduate Degree Program in Cell and Molecular Biology, Fort Collins, CO, USA
(PP072) Wild-type p53 has dominant effects over mutant p53 to maintain genomic stability in human lymphoblast cell.

Loucas, Bradford^*,1, Cornforth, Michael¹, ¹ Department of Radiation Oncology, Galveston, TX, USA
(PP073) Are un-rejoined chromosome breaks always the result of an irreparable lesion?

Manti, Lorenzo^*,1, Court, Jonathan², Durante, Marco¹, Grossi, Gianfranco¹, Pugliese, Gabriella¹, Scampoli, Paola¹, Gialanella, Giancarlo¹, ¹ Physical Sciences, Radiation Biophysics Laboratory, Naples, Italy² Cancer Research Wales Laboratory, Velindre Cancer Centre, Cardiff, Wales, United Kingdom
(PP074) Dependence of radiation clastogenicity upon competence for cytokinesis.

Marozik, Pavel^{*,1, 2}, Mosse, Irma², Seymour, Colin³, Mothersill, Carmel³, ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Laboratory of Radiation Genetics, Minsk, Minsk, Belarus³ Science, Hamilton, Ontario, Canada
(PP075) Modification of radiation-induced bystander effect with melanin.

Marozik, Pavel^*,1, Marozik, Mikhail², Melnov, Sergei², ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Human Biology, Minsk, Minsk, Belarus
(PP076) The level of clastogenic factors as marker of mutation pressure in human population.

Murphy, James^*,1, Nugent, Sharon¹, Seymour, Colin², Mothersill, Carmel², ¹ Radiation and Environmental Science Centre, Dublin, Dublin, Ireland² Medical Physics & Applied Radiation Sciences, Hamilton, Ontario, Canada
(PP077) Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells.

Parker, Sharon^*,1, Tucker, Jennifer², Pore, Nabendu, Nguyen, Vu², Mullins, Mary², Maity, Amit¹, Kao, Gary¹, ¹ Radiation Oncology, Philadelphia, PA, USA² Cell and Developmental Biology, Philiadelphia, PA, USA
(PP078) Rapid detection of the effects of radiation and histone deacetylase inhibitors on Zebrafish embryonic development.

Ramaiah, Lila^*,1, Weil, Michael², Desaintes, Christian³, Ullrich, Robert², ¹ Department of Microbiology, Immunology, & Pathology, Fort Collins, CO, USA² Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA³ Radiobiology Unit, Boeretang, Mol, Belgium
(PP079) Dissecting the role of Prkdc^BALB polymorphisms in radiation-induced mammary cancer.

Elmore, Eugene¹, Lao, Xiao-Yan¹, Kapadia, Rubina¹, Roa, Dante¹, Sehgal, Varun¹, Al-Ghazi, Matthew¹, Redpath, Les ^*,1, ¹ Department of Radiation Oncology, Irvine, CA, USA
(PP080) Neoplastic transformation in vitro by low doses of low-LET radiation delivered at low dose-rate.

Sirisalee, Tonya ^*,1, Ray, F. Andrew¹, Weil, Michael ¹, Bedford, Joel¹, Schimenti, John², Ullrich, Robert¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Biomedical Sciences, Ithaca, NY, USA
(PP081) Using an embryonic stem cell mutagenesis model to identify radiation sensitivity genes.

Steinberg, Mark^*,1, Hill, Helene², Pierre, Zdenka ¹, Liu, Suqing ¹, Hwang, Bor-Jang ¹, Ji, Fang¹, Hubbard, Karen³, Dermody, James⁴, ¹ Department of Chemistry, New York, NY, US² Department of Radiology, Newark, NJ, US³ Department of Biology, New York, NY, US⁴ Department of Microbiology and Molecular Genetics, Newark, NJ
(PP082) Novel UVB-induced mitochondrial deletions in human epithelial cells.

Sutherland, Betsy^*,1, Bennett, Paula ¹, Cuomo, Noelle¹, Yang, Hongying², Held, Kathryn², ¹ Biology Department, Upton, NY, US² Department of Radiation Oncology, Boston, MA, US
(PP083) DNA damage clusters in bystander cells.

Suzuki, Masao^*,1, Tsuruoka, Chizuru¹, Yasuda, Nakahiro¹, Okayasu, Ryuichi¹, ¹ International Space Radiation Laboratory, Chiba, Chiba, Japan
(PP084) Bystander cellular effects in normal human fibroblasts irradiated with low-energy carbon ions.

Tsai, Mong-Hsun^{*,1, 3}, Tseng, Jennifer², Chuang, Eric^{1, 3, 4}, ¹ Center for Genomic Medicine, Taipei, Taiwan, Taiwan³ Radiation Oncology Science Program/ Center for Cancer Research, Bethesda, MD, US² Molecular, Cellular and Developmental Biology Department, Ann Arbor, MI, US⁴ Department of Electrical Engineering, Taipei, Taiwan, Taiwan
(PP085) Synergistic effect in presence of 17AAG followed by X—ray radiation exposure in human lymphoblastoid cells.

Ueno, Akiko^{*,1, 2}, Vannais, Diane², Waldren, Charles³, ¹ National Institute of Radiological Sciences, Chiba, Japan, Japan² Environmental & Radiological Health Sciences, Fort Collins, CO, USA³ Radiation Effects Research Foundation (RERF), Hiroshima/Nagasaki, Japan, Japan
(PP086) Mutagenicity of fractionated radiations.

Zhou, Xinfeng^*,1, Chen, Bingzi¹, Yi, Huilan¹, Jiang, Tao¹, Dedon, Peter¹, ¹ Biological Engineering Division, Cambridge, MA, USA
(PP087) Novel methods for quantifying ionizing radiation-induced deoxyribose oxidation in DNA.

Grygoryev, Dmytro¹, Moskalenko, Oleksandr¹, Zimbrick, John^*,1, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP088) DNA damage induced by combined cadmium and radiation exposure in vitro and in cultured medaka fish cells.

Experimental and Clinical Therapeutics

Bai, Aiping^*,1, Brown, Stephen², Meier, G.Patrick³, Zhou, Daohong¹, ¹ Department of Pathology & Lab Medicine, Charleston, SC² Department of Medicine, Lexington, KY³ Department of Chemistry, Pullman, WA
(PP089) Prodrug modification increases the antioxidant and radioprotective activity of potassium tricyclo[5.2.1.0^2,6]-decan-8-yl dithiocarbonate (D609).

Bakken, Nicholas^*,1, Evans, Mark², Kovacs, Charles², Cariveau, Mickael², Allison, Ron², Johnke, Roberta², ¹ Department of Physics, Greenville, NC, USA² Department of Radiation Oncology, Greenville, NC, USA
(PP090) Differential response of two melanoma cell lines following exposure to the photodynamic therapy drug Photofrin.

Balcer-Kubiczek, Elizabeth^*,1, Regine, William ², Attarpour, Mona ¹, Jiang, Jing¹, Joiner, Michael³, ¹ Radiation Oncology/Radiation Oncology Research Laboratory, Baltimore, MD² Radiation Oncology, Baltimore, MD³ Karmanos Cancer Institute, Detroit, MI
(PP091) Combination of docetaxel and fractionated low-dose irradiation in cell lines exhibiting low-dose hypersensitivity in vitro.

Baumann, Michael^*,1, Hessel, Franziska¹, Aue, Kristin¹, Krause, Mechthild¹, Zips, Daniel¹, Doerfler, Annegret¹, Eicheler, Wolfgang¹, Heider, Karl-Heinz², ¹ Dept. of Radiation Oncology, Dresden, Saxony, Germany²
(PP092) Antibody-guided chemotherapy with bivatuzumab mertansine improves the results of fractionated radiotherapy of human FaDu squamous cell carcinoma in nude mice.

Choudhury, Ananya^{*,1, 2}, Jalali, Farid¹, Kiltie, Anne ², Bristow, Robert ^*,1, ¹ Dept. of Radiation Oncology and Medical Biophysics, Toronto, Ontario, Canada² Division of Cancer Medicine Research, Leeds, West Yorkshire, UK
(PP093) RAD51: A DNA repair target for increasing the therapeutic potential in the treatment of bladder cancer.

Bai,, Aiping¹, Meier,, G. Patrick², Zhou,, Daohong ¹, Brown,, Stephen^{*,3, 4}, ¹ Department of Pathology and Laboratory Medicine, Charleston, South Carolina, USA² Department of Chemistry, Pullman, Washington, USA³ Department of Internal Medicine, Lexington, Kentucky, USA⁴ Research Service, Lexington, Kentucky, USA
(PP094) Comparison of the protective effects of different potassium tricyclo[5.2.1.0^2,6]-decan-8-yl dithiocarbonate diastereoisomers against ionizing radiation.

Burd, Randy ^*,1, Lavorgna, Stephanie ¹, Thangasamy, Thilakavathy¹, Kong, Xianguo¹, Lenaz, Luigi ², Chawla, Shanta², Reddy, Guru², Wachsberger, Phylis ¹, Dicker, Adam¹, ¹ Radiation Oncology, Philadelphia, PA, USA² Oncology, Irvine, CA, USA
(PP095) Enhancement of radiation response in tumors by the bioreductive agent Apaziquone (EO9, EOquin).

Bussink, Jan^*,1, Troost, Esther¹, Kaanders, Johannes¹, van Eerd, Julliette², Peters, Johannes¹, Rijken, Paul¹, Boerman, Otto², van der Kogel, Albert¹, ¹ Dept. of Radiation Oncology, Nijmegen, The Netherlands, The Netherlands² Dept. of Nuclear Medicine, Nijmegen, The Netherlands, The Netherlands
(PP096) Quantification of CAIX by immunohistochemistry, autoradiography and SPECT analysis in three human tumor lines.

Chen, Fang-Hsin^{*,1, 2}, Liu, Wei-Chung ¹, Hsieh, Kai-Fong¹, Hong, Ji-Hong ², Chiang, Chi-Shiun¹, ¹ Department of Atomic Science, Hsinchu, Taiwan(R.O.C.)² Department of Radiation Oncology, Taoyuan, Taiwan(R.O.C.)
(PP097) Oral consumption of Cordyceps sinensis promotes the recovery of radiation-induced bone marrow and intestinal injuries in mice.

Chen, Miao-fen^*,1, Chen, Wen-cheng¹, Wu, Chun-te¹, Mazzatti, Dawn², Hu, Yueh-chiang², Liao, Shuen-kuei¹, Keng, Peter², ¹ Radiation Oncology, Taipei, Taiwan, Republic of China² Radiation Oncology, Rochester, NY, USA
(PP098) Antisense to human peroxiredoxin I enhances radiation sensitivity of lung cancer cells.

Chernikova, Sophia^*,1, Peters, Katherine¹, Kovacs, Mary¹, Brown, J. Martin¹, ¹ Radiation Oncology, Stanford, CA, USA
(PP099) Mechanism of sensitization of hypoxic cells to cisplatin by tirapazamine.

McDonough, James¹, Arguiri, Evguenia², Solomides, Charalambos², Cengel, Keith¹, Christofidou-Solomidou, Melpo², ¹ University of Pennsylvania, Philadelphia, PA, USA² Department of Medicine, Philadelphia, PA, USA
(PP100) Curcumin ameliorates radiation-induced pulmonary fibrosis and decreases tumor burden in a C57/Bl6/Lewis lung carcinoma model system.

Storck, Christopher¹, Wahl, Miriam², Leeper, Dennis¹, Coss, Ronald^*,1, ¹ Department of Radiation Oncology, Philadelphia, PA, USA² Department of Pathology, Durham, NC, USA
(PP101) Acute acidification reduces the heat shock response and sensitizes human melanoma cells grown at low pH to thermal therapy.

Dahle, Jostein^*,1, Borrebæk, Jørgen², Salberg, Gro², Bruland, Øyvind Sverre³, Olsen, Dag Rune¹, Larsen, Roy Hartvig², ¹ Radiation Biology, Oslo, NORWAY, NORWAY² Research, Oslo, NORWAY, NORWAY³ Clinical Oncology, Oslo, NORWAY, NORWAY
(PP102) Biodistribution of ²²⁷Th, ²²⁷Th-DOTA and ²²⁷Th-DOTA-rituximab in Balb/c mice.

Davis, Mary^*,1, Lawrence, Theodore¹, ¹ Radiation Oncology, Ann Arbor, MI
(PP103) Radiosensitization of hepatic cancers by the combination of gemcitabine and fluorodeoxyuridine.

Busto, Eduardo², Vallerga, Maria¹, Sardi, Mabel Edith^3,2, Di Giorgio, Marina¹, ² Radiation Oncology and Otorhinolaringology, Buenos Aires, Argentina¹ Autoridad Regulatoria Nuclear, Buenos Aires, Argentina³ Mevaterapia, Buenos Aires, Argentina
(PP104) DNA repair capacity as a predictive radiation sensitivity test. Inferences for clinical practice and radiation protection.

Dynlacht, Joseph^*,1, Valluri, Shailaja², DesRosiers, Colleen¹, Greer, Falon¹, Caperell-Grant, Andrea³, Mendonca, Marc¹, Lopez, Jennifer¹, Bigsby, Robert³, ¹ Radiation Oncology, Indianapolis, Indiana, United States of America² Ophthalmology, Indianapolis, Indiana, United States of America³ Obstetrics and Gynecology, Indianapolis, Indiana, United States of America
(PP105) Inhibition of radiation-induced cataractogenesis by estrogen.

Evans, Sydney^*,1, Schrlau, Amy¹, Chalian, Ara², Zhang, Paul³, Koch, Cameron¹, ¹ Radiation Oncology, Philadelphia, Pa., USA² Otorhinolaryngology, Philadelphia, Pa., USA³ Pathology, Philadelphia, Pa., USA
(PP106) Hypoxia in human skin as measured by EF5 binding.

Fan, G^*,1, Atencio, D¹, Ho, A¹, Green, S¹, Formenti, S², Haffty, B³, Bernstein, J⁴, Iyengar, P¹, Stock, R¹, Cesaretti, J¹, Rosenstein, B^{1, 2}, ¹ Department of Radiation Oncology, New York, NY, USA² Department of Radiation Oncology, New York, NY, USA³ Department of Therapeutic Radiology, New Haven, CT, USA⁴ Department of Epidemiology and Biostatistics, New York, NY, USA
(PP107) Genetic predictors of adverse radiotherapy effects in African-American breast cancer patients.

Feng, Felix^*,1, Chun, Patrick ¹, Davis, Mary¹, Lawrence, Theodore ¹, Nyati, Mukesh¹, ¹ Radiation Oncology, Ann Arbor, MI, USA
(PP108) Achievement of prolonged tumor regression in head and neck cancer using gefitinib, gemcitabine, and radiation.

Fenton, Bruce^*,1, Paoni, Scott¹, ¹ Department of Radiation Oncology, Rochester, NY, USA
(PP109) Pathophysiological effects of antibodies to IGF-1R and VEGFR-2 plus fractionated radiation in DU145 prostate carcinoma xenografts.

Freeman, Michael ^*,1, Sekhar, Konjeti¹, Rogers, Buck², Crooks, Peter³, Xu, Mai², Moros, Eduardo², Roti Roti, Joseph², ¹ Vanderbilt University, Nashville, TN, United States² Washington University School of Medicine, St. Louis, MO, United States³ University of Kentucky, Lexington, KY, United States
(PP110) Development of enhancers of thermal radiosensitization.

Fernainy, Pamela¹, Geara, Fady^*,2, Itani, Wafika¹, Haddadin, Makhluf³, Ghali-Muhtasib, Hala¹, ¹ Department of Biology, Beirut, Lebanon, Lebanon² Department of Radiation Oncology, Beirut, Lebanon, Lebanon³ Department of Chemistry, Beirut, Lebanon, Lebanon
(PP111) Molecular mechanisms of the radiosensitizing effects of a quinoxaline dioxide derivative.

Geldof, Albert^*,1, Kuipers, Gitta³, Sminia, Peter³, Lafleur, M. Vincent³, Zerp, Shuraila⁴, Yang, Dajun⁵, Lippman, Mark⁵, Slotman, Berend³, Verheij, Marcel³, ¹ VU Medical Center, Amsterdam, Netherlands³ VU Medical Center, Amsterdam, Netherlands⁴ The Netherlands Cancer Inst., Amsterdam, Netherlands⁵ University of Michigan, Ann Arbor, MI, United States
(PP112) Gossypol, a small molecule inhibitor of Bcl-2, affects radiation sensitivity in human prostate cancer cells.

Gerweck, Leo^*,1, Vijayappa, Shashirekha¹, ¹ Massachusetts General Hospital, Boston, MA, United States
(PP113) Assessing tumor pH as a determinant of the efficacy weak acid and base chemotherapeutics in-vivo.

Greco, Olga^*,1, Ireson, Christopher², Coralli, Claudia², Dachs, Gabi², Shima, David³, Steele, Andrew², Kanthou, Chryso^{1, 2}, Tozer, Gillian^{1, 2}, ¹ Tumour Microcirculation Group, Sheffield, South Yorkshire, UK² Tumour Microcirculation Group, Northwood, Middlesex, UK³ Eyetech Research Center, Woburn, MA, USA
(PP114) Role of VEGF and angiopoietins on tumour response to vascular disrupting agents and radiation.

Griffin, Robert^*,1, Williams, Brent¹, Park, Heon Joo¹, Song, Chang¹, ¹ Radiation Biology Section, Department of Radiation Oncology, Minneapolis, MN, USA
(PP115) Thermoradiotherapy enhancement with anti-vascular strategy.

Yacoub, Adly¹, Dent, Paul¹, Hagan, Michael ^*,1, ¹ Radiation Oncology, Richmond, VA, USA
(PP116) Together, active EGFR and EGFR trans-activated by irradiation over-activate PARP depleting NAD+ and increasing cell-killing.

Hamstra, Daniel^{*,1, 3}, Griffin, Laura^{1, 4}, Bhojani, Swaroop^{1, 4}, Ross, Brian^{2, 3, 4}, Rehemtulla, Alnawaz^{1, 2, 4}, ¹ Departments of Radiation Oncology, Ann Arbor, MI³ Department of Biochemistry, Ann Arbor, MI⁴ The Center for Molecular Imaging, Ann Arbor, MI² Department of Radiology, Ann Arbor, MI
(PP117) Non-invasive real time imaging of the oscillatory pattern of p53 dependent gene activation following chemoradiotherapy.

Debucquoy, Annelies¹, Goethals, Laurence¹, McBride, William², Haustermans, Karin^*,1, ¹ Department of Radiation Oncology and Experimental Therapy, Leuven, Vlaams Brabant, Belgium² Department of Radiation Oncology, Los Angeles, California, USA
(PP118) The effect of COX-2 inhibition on molecular responses of rectal cancer to preoperative chemoradiation in a Phase II randomized, double-blind, placebo-controlled clinical trial.

Hill, Colin ^*,1, Dagliyan, Grant¹, Kumar, Parvesh¹, ¹ Dept of Radaition Oncology, Los Angeles, CA, USA
(PP119) Effects of 13-cis-retinoic acid and Interferon with or without radiation on prostate tumor cells and normal human rectal and lung cells.

Hoopes , P. Jack ^{*,1, 2}, Yeo, Tet-kin ¹, Strawbridge, Rendall¹, Sundaram , Sujatha ¹, Gladstone , David ², Paul, Brian ^{1, 2}, Shenberger , Jeffrey ³, Myers , Jeniffer ³, Buckey, Jay ², O'Hara, Julia², Hug , Eugne ², ¹ Department of Surgery, Hanover, NH, USA² Department of Medicine (Radiation Oncology), Hanover, NH, USA³ Department of Pediatrics, Hanover, NH, USA
(PP120) Hyperbaric oxygen improves survival of irradiated CNS astrocytes and neurons.

Hopewell, John^*,1, Millar, William², ¹ Department of Clinical Oncology, Oxford, Oxon, UK² Department of Radiation Oncology, Glasgow, Strathclyde, UK
(PP121) Effects of low dose-rate ⁹⁰Sr/⁹⁰Y exposure on the acute moist desquamtion response of pig skin.

Jaal, Jana^*,1, Doerr, Wolfgang¹, ¹ Dept. of Radiotherapy and Radiation Oncology, Dresden, Saxony, Germany
(PP122) Effect of recombinant human keratinocyte growth factor (rHuKGF, Palifermin) on radiation-induced mouse urinary bladder dysfunction.

Kavanagh, Brian^*,, Schefter, Tracey¹, Gaspar, Laurie¹, Zaemisch, Rebekah¹, Gravdahl, Daniel¹, Raben, David¹, Frederick, Barbara¹, ¹ University of Colorado, Aurora, CO, USA
(PP123) Changes in serum vascular endothelial growth factor (VEGF) levels following stereotactic body radiation therapy (SBRT) to liver and lung tumors.

Khan, Atif^*,1, Mehta, Par¹, Foutch, Jennifer¹, Kirk, Michael¹, Chu, Jim ¹, Abrams, Ross¹, Blazek, Ed¹, ¹ Department of Radiation Oncology, Chicago, IL, USA
(PP124) Clonogenic survival does not uniformly increase with split time between halves of 2-Gy fractions: implications for IMRT.

Koch, Cameron^*,1, Oprysko, Patricia¹, ¹ Radiation Oncology, Philadelphia, PA
(PP125) Use of 2-nitroimidazole binding to determine the lifetime of hypoxic cells.

Milas, Luka¹, Koto, Masashi^*,1, Valdecanas, David¹, Mason, Kathy¹, Hunter, Nancy¹, Fan, Zhen², Fang, Fu-Min¹, Ang, Kian³, ¹ Experimental Radiation Oncology and Division of Radiation Oncology, Houston, TX, USA² Experimental Therapeutics, Houston, TX, USA³ Division of Radiation Oncology, Houston, TX, USA
(PP126) C225-induced enhancement of tumor radioresponse: Influence of timing of C225 administration.

Kozin, Sergey^*,1, Winkler, Frank¹, Tong, Ricky¹, Chae, Sung-Suk¹, Booth, Michael¹, Xu, Lei¹, Hicklin, Daniel², Fukumura, Dai¹, di Tomaso, Emmanuelle¹, Munn, Lance¹, Jain, Rakesh¹, ¹ Department of Radiation Oncology, Boston, MA, USA² Department of Immunology, New York, NY, USA
(PP127) Kinetics of vascular normalization by VEGFR2 blockade governs the response of glioma xenografts to radiation.

Krager, Kimberly^*,1, Niu, Gang¹, Madsen, Mark², Graham, Michael², Stevenson, Gail³, Liu, Zhonglin³, Barrett, Harrison³, Domann, Frederick ¹, ¹ Radiation Oncology, Iowa City, IA, United States² Department of Radiology, Iowa City, IA, United States³ Department of Radiology, Tucson, AZ, United States
(PP128) Quantitative dosimetry and biodistribution of radionuclide concentrator therapy in ad-NIS transduced head and neck carcinoma.

Krause, Mechthild^*,1, Ostermann, Gernot¹, Petersen, Cordula¹, Harstrick, Andreas², Yaromina, Ala¹, Thames, Howard³, Baumann, Michael¹, ¹ Dept. of Radiation Oncology, Dresden, Saxony, Germany² Merck KG aA, Darmstadt, Hessen, Germany³ Dept. of Biomathematics, Houston, Texas, USA
(PP129) Targeting of the EGFR by C225 improves local control of FaDu hSCC by decreased repopulation and increased reoxygenation during fractionated irradiation.

Krishnan, Sunil^*,1, Shentu, Shujun¹, Schwartz, David¹, Puduvalli, Vinay², ¹ MD Anderson Cancer Center, Houston, TX, United States² MD Anderson Cancer Center, Houston, TX, United States
(PP130) Suberoyl anilide hyroxamic acid (SAHA) sensitizes pancreatic cancer cells to radiation therapy.

Leeper, D.^*,1, Linek, J.¹, Pollard, M.¹, Pocceschi, M.¹, Henderson, K.², Boman, B.², ¹ Radiation Oncology, Philadelphia, PA, USA² Genetics and Preventive Medicine, Philadelphia, PA, USA
(PP131) Radiation response and stem cell number of crypts of mouse small and large intestine.

Li, Fang ^*,1, Sovenaux, Pierre ¹, Dewhirst, Mark , Li, Chuan, ¹ Radiation Oncoloty, Durham, NC, U.S.A
(PP132) A noninvasive approach to image HIF-1a level in tumor response to radiation therapy.

Li, Wang^*,1, Yan, Feng¹, Xiaorong, Fu¹, Xuwei, Cai¹, ¹ Fudan University, Shanghai, China
(PP133) The in vivo study on adenovirus mediate smad7 gene expression regulated by irradiation via Egr-1 promoter.

Liu, Shanling^{*,1, 2}, Wang, He², Yang, Zhonghui¹, Kon, Takashi¹, Zhu, Jiangao³, Cao, Yiting¹, Nicchitta, Christopher⁴, Li, Chuan-Yuan¹, ¹ Radiation Oncology, Durham, NC, USA² West China Second University Hospital, Chengdu, Sichuan, P.R.China³ Immunology, Durham, NC, USA⁴ Cell Biology, Durham, NC, USA
(PP134) Tumor radiation therapy enhanced by use of adenovirus-mediated GRP94/gp96 expression.

Luijk, P.^*,1, Novakova-Jiresova, A.², Steneker, M.N.J.¹, Faber, H.², Meertens, H.¹, Kampinga, H.H.², Coppes, R.P.^{1, 2}, ¹ Radiation Oncology, Groningen, Groningen, The Netherlands² Radiation and Stress Cell Biology, Groningen, Groningen, The Netherlands
(PP135) The relation between structural and functional changes in the rat lung after irradiation.

Luo, Xian^*,, Kim, Dong, Crapo, James, Pearlstein, Robert, Slater, James, Gridley, Daila,
(PP136) Differential modification of tumor and normal cell response to radiation by metalloporphyrin antioxidant.

Mendonca, Marc^{*,1, 2}, Chin-Sinex, Helen¹, Mead, Laura³, Yoder, Merv³, Ingram, David³, ¹ Radiation Oncology / Radiation and Cancer Biology Labs, Indianapolis, IN, USA² Medical and Molecular Genetics, Indianapolis, IN, USA³ Pediatrics, Herman B. Wells Center for Pediatric Research, Indianapolis, IN, USA
(PP137) Endothelial stem/progenitor cells are X-ray sensitive with limited repair capacity.

Milosevic, Michael^{*,1, 3}, Skliarenko, Julia^{2, 3}, Lunt, Sarah Jane^{2, 3}, Fyles, Anthony^{1, 3}, Hill, Richard^{2, 3}, ¹ Radiation Medicine Program, Toronto, ON, Canada³ University of Toronto, Toronto, ON, Canada² Ontario Cancer Institute, Toronto, ON, Canada
(PP138) Interstitial permeability and elasticity in tumors: Possible biomarkers of response to targeted treatment?

Cotrim, Ana², Hyodo, Fuminori¹, Sowers, Anastasia¹, Matsumoto, Ken-Ichiro¹, Baum, Bruce², Krishna, Murali¹, Mitchell, James ¹, ² National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA¹ National Cancer Institute, Bethesda, Maryland, USA
(PP139) MRI assessment of nitroxide-mediated selective normal tissue radioprotection.

Moeller, Benjamin^*,1, Dreher, Matthew², Rabbani, Zahid³, Schroeder, Thies³, Cao, Yiting¹, Dewhirst, Mark^{1, 2, 3}, ¹ Department of Pathology, Durham, NC, USA² Department of Biomedical Engineering, Durham, NC, USA³ Department of Radiation Oncology, Durham, NC, USA
(PP140) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

Cohen, Eric¹, Fish, Brian², Moulder, John^*,2, ¹ Medicine, Milwaukee, WI, USA² Radiation Oncology, Milwaukee, WI, USA
(PP141) Angiotensin II type-2 (AT2) receptor blockade in experimental radiation nephropathy.

Sharma, Mukut ¹, McCarthy, Ellen¹, Sharma, Ram¹, Fish, Brian², Savin, Virginia ¹, Cohen, Eric¹, Moulder, John^*,2, ¹ Nephrology Division, Milwaukee, WI, USA² Department of Radiation Oncology, Milwaukee, WI, USA
(PP142) Ibuprofen prevents the early effects of ionizing radiation on normal glomeruli.

Niu, Gang^*,1, Anderson, Richard⁴, Madsen, Mark^{2, 3}, Graham, Michael ^{2, 3}, Oberley, Larry^{1, 3}, Domann, Frederick ^{1, 3}, ¹ Free Radical & Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA⁴ Viraquest Inc., North Liberty, IA² Department of Radiology, Iowa City, IA³ Carver College of Medicine & Holden Comprehensive Cancer Center, Iowa City, IA
(PP143) Quantitative and non-invasive radiological imaging of tumor targeted p53 and MnSOD gene transfer and expression with dual expressing adenoviral vectors.

Gibbs, Summer¹, O'Hara, Julia^*,1, Chen, Bin^*,1, Savellano, Mark¹, Hoopes, P Jack^{1, 2}, Pogue, Brian¹, ¹ Thayer School of Engineering, Hanover, NH, USA² Dept of Surgery, Lebanon, NH, USA
(PP144) Tumor diagnosis or treatment using the prodrug, ALA: cell line dependence of protoporphyrin IX production.

O'Hara, M,^*,2, Pollard, M.¹, Pocceschi, M.¹, Leeper, D.¹, ² Center for Devices and Radiological Health, Rockville, MD, USA¹ Radiation Oncology, Philadelphia, PA, USA
(PP145) MIBG plus hyperglycemia sensitizes bone marrow CFU-F but not CFU-C to Cs-137 irradiation in Situ.

Oh, Yoon Kyeong^*,1,3, Xu, H.¹, Lee, T. B. ¹, Choi, C. H. ^1,2, ¹ Chosun University, Gwangju, South Korea³ Chosun University Medical School, Gwangju, South Korea² Chosun University Medical School, Gwangju, South Korea
(PP146) Radioresistance mechanisms of chemoresistant leukemic and lung cancer cell lines.

Pajonk, Frank^*,1, Riedisser, Anja ², McBride, William¹, Fiebich, Bernd³, ¹ Department of Radiation Onoclogy, Los Angeles, CA, USA² Department of Radiation Oncology, Freiburg, BW, Germany³ Department of Psychiatry, Freiburg, BW, Germany
(PP147) Topically applied green tea extracts to treat radiation-induced skin toxicity - involvement of a caspase-dependent mechanism.

Palayoor, Sanjeewani^*,1, Mitchell, James¹, DeGraff, William¹, Powis, Garth², Kirkpatrick, Lynn³, Coleman, C.Norman¹, ¹ National Cancer Institute, Bethesda, MD, USA² Arizona Cancer Center, Tucson, AZ, USA³
(PP148) Radiosensitivity of prostate carcinoma cells irradiated under normoxic and hypoxic conditions following treatment with HIF inhibitor PX-478.

Cowen, Rachel¹, Wind, Natasha¹, Telfer, Brian¹, Stratford, Ian¹, Papadopoulou, Maria^*,2, Bloomer, William², Williams, Kaye¹, ¹ School of Pharmacy and Pharmaceutical Sciences, Manchester, Greater Manchester, UK² Department of Radiation Medicine, Evanston, Illinois, USA
(PP149) Exploiting cytochrome p450 reductase-mediated enhancement of NLCQ-1 hypoxic cytotoxicity for use in combination with radiotherapy.

Paquette, Benoit^*,1, Baptiste, Catherine ¹, Therriault, Hélène ¹, Arguin, Guillaume ², Plouffe, Bianca ³, Lemay, Rosalie¹, ¹ Department of nuclear medicine and radiobiology, Sherbrooke, Québec, Canada² Department of pharmacology, Sherbrooke, Québec, Canada³ Department of physiology, service of endocrinology, Sherbrooke, Québec, Canada
(PP150) Irradiation of basement membrane enhances the invasiveness of breast cancer cells.

Park, Heon Joo^*,1, Choi, Eun Kytung², Ji, In-Mi ¹, Kim, Eun Jung¹, Lee, So Ryung², WIlliams, Brent ³, Griffin, Robert ³, Ha, Sung Whan⁴, Lim, Byung Uk¹, Song, Chang Won³, ¹ Dept of Microbiology, Inchon, South Korea, South Korea² Dept of Radiation Oncology, Seoul, South Korea, South Korea³ Dept of Therapeutic Radiology-Radiation Oncology, Minneapolis, MN, USA⁴ Dept of Radiation Oncology, Seoul, South Korea, South Korea
(PP151) Radiation-induced activation of NQO1 potentiates the cytotoxicity of bio-reductive drugs.

Parmar, Kalindi^*,1, Vergilio, Jo-Anne², Clyne, James¹, Sackstein, Robert³, Mauch, Peter^{1, 4}, Down, Julian⁵, ¹ Department of Radiation Oncology, Boston, MA, USA² Department of Pathology, Boston, MA, USA³ Department of Dermatology and Medicine, Boston, MA⁴ Department of Radiation Oncology, Boston, MA⁵ Research, Cambridge, MA
(PP152) Primitive hematopoietic stem cells are sequestered in a hypoxic microenvironment within the bone marrow: implications for oxygen-dependent cytotoxic injury.

Pattillo, Christopher ^*,1, Sari-Sarraf, Farid¹, Nallamothu, Ramakrishna², Moore, Bob², Wood, George², Kiani, Mohammad^{1, 3}, ¹ Department of Mechanical Engineering, Philadelphia, PA, USA² Department of Pharmaceutical Science, Memphis, TN, USA³ Department of Radiation Oncology, Philadelphia, PA, USA
(PP153) Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay.

Pena, Louis^*,1, Lin, Xinhua¹, Glass, John¹, Crawford, Janet², Zamora, Paul³, ¹ Medical Department, Upton, NY, USA² W.M. Keck Biotechnology Laboratory, New Haven, CT, USA³ BioSET Inc., College Park, MD, USA
(PP154) Radiation protection by FGF-2 mimetic, multi-domain peptides.

Pervan, Milena^*,1, de Vos, Sven ², Calimlim, Jeffrey², Said, Jonathan², McBride, William¹, ¹ Radiation Oncology Department, Los Angeles, CA² Hem/Onc Department, Los Angeles, CA
(PP155) Proteasome inhibitor Bortezomib enhances effectiveness of radioimmunotherapy of diffuse large B-cell lymphoma.

Peschke, Peter^*,1, Karger, Christian ¹, Scholz, Michael², Sanchez-Brandelik, Rita¹, Huber, Peter^{1, 3}, Debus, Jürgen^{1, 3}, ¹ Dept. of Radiotherapy, 69120-Heidelberg, Germany, Germany² Dept. of Biophysics, Darmstadt, Germany, Germany³ Dept. of Clinical Radiology, Heidelberg, Germany, Germany
(PP156) Radiation-induced myelitis in the spinal cord of rats after single and split doses of photons and carbon ions.

Pickett, Heather^*,1, Sandison, George¹, Li, Jian Jian¹, ¹ Molecular Radiobiology Division, West Lafayette, Indiana, USA
(PP157) Effects of radiation and cryotherapy on tumorigenic and non-tumorigenic human prostrate cell lines.

Plastaras, John^*,1, Gudonis, Deborah², Ahmed, Mona¹, Cerniglia, George¹, Frank, Ian², Gupta, Anjali¹, ¹ University of Pennsylvania Hospital, Philadelphia, PA, United States² University of Pennsylvania Hospital, Philadelphia, PA, United States
(PP158) Validation of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans.

Ponce, Ana^*,1, Viglianti, Benjamin¹, Yarmolenko, Pavel², Bally, Marcel³, Woo, Janet³, Dewhirst, Mark², ¹ Dept of Biomedical Engineering, Durham, NC² Dept of Radiation Oncology, Durham, NC³ BC Cancer Agency, Vancouver, BC
(PP159) Liposomal drug distribution and anti-tumor effect: drug dose painting with hyperthermia using MRI.

Powell, Alaina^*,1, Che, Mingxin³, Marples, Brian ², Joiner, Michael², Wilson, George ², ¹ Graduate Programs in Cancer Biology, Detroit, MI, United States³ Department of Pathology, Detroit, MI, United States² Department of Radiation Oncology, Detroit, MI
(PP160) The prevalence of hypoxic markers in prostate tumors.

Quennet, Verena^*,1, Walenta, Stefan¹, Zips, Daniel², Yaromina, Ala², Baumann, Michael ², Mueller-Klieser, Wolfgang¹, ¹ Institute of Physiology and Pathophysiology, Mainz, RLP, Germany² Department of Radiotherapy and Oncology, Medical Faculty, Dresden, RLP, Germany
(PP161) Characterization of the glucose metabolism in xenotransplanted human squamous cell carcinomas.

Rhee, Juong^*,1, Gu, Yeun², Lee, Yong³, ¹ Radiation Oncology, Baltimore, MD, U.S.A.² Graduate School of Helath Science, Suzuca, Mie, Japan³ Surgery, Pittsburgh, PA, U.S.A.
(PP162) Uneven distribution of green fluorescence positive cells within multicell spheroids following adenoviral transduction.

Rhoades, Samuel^{*,1, 2}, Blough, Melissa^{1, 2}, Hevezi, James^{1, 3}, ¹ Dept of Radiological Sciences, San Antonio, TX² Dept of Medical Physics, San Antonio, TX³
(PP163) A pilot study evaluating the prevention of abdominal adhesions via administration of beta radiation from a ⁹⁰Sr/⁹⁰Y applicator.

Lehnert, Shirley¹, Owusu, Abraham ¹, Li, Yongbiao¹, Bump, Edward², Riddoch, Bill², ¹ Oncology/Radiation Oncology, Montréal, Québec, Canada² Radiopharmaceuticals, Kirkland, Québec, Canada
(PP164) Intra-tumoral delivery of radiolabeled iododeoxyuridine.

Robbins, Mike^*,1, Gilliam-Davis, Shea², Payne, Valerie¹, Tommasi, Ellen², Diz, Debra², ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC² Hypertension & Vascular Disease Center, General Surgery, Winston-Salem, NC
(PP165) Whole brain irradiation reduces insulin, leptin and body weight in Fisher 344 rats one year post-treatment: effects of AT1-receptor blockade.

Rockwell, Sara ^*,1, Liu, Yanfeng¹, Gilmore-Hebert, Maureen¹, Tomasz, Maria², ¹ Department of Therapeutic Radiology, New Haven, CT² Department of Chemistry, New York, NY
(PP166) Response of aerobic and hypoxic Fanconi Anemia cells to mitomycin c and decarbamoyl mitomycin c.

Xu, Mai¹, Wu, M², Crooks, Peter³, Freeman, Michael⁴, Roti Roti, Joseph^*,1, ¹ Radiation and Cancer Biology Division, St. Louis, MO, USA² Department of Radiation Oncology, Taipei, Taiwan, China³ College of Pharmacy, Lexington, KY, USA⁴ Department of Radiation Oncology, Nashville, TN
(PP167) Radiosensitization by the combination of 41°C hyperthermia and indomethacin analogs.

Sabapathi, Sathishkumar^*,1, Mohiuddin, Mohammed ¹, Ahmed, Mansoor¹, ¹ Radiation Medicine, Lexington, KY, USA
(PP168) Radiation-induced negative regulators of Sphingomyelin pathway: A potential target to overcome radioresistance in prostate cancer.

Sang, Mei^*,1, Kang, Yun¹, Patel, Nalini¹, Travis, Elizabeth¹, Terry, Nicholas¹, ¹ Experimental Radiation Oncology, Houston, Texas, USA
(PP169) Postirradiation treatment with recombinant human keratinocyte growth factor (rHuKGF) may ameliorate radiation-induced pneumonitis in mice.

Sarkaria, Jann^*,1, Carlson, Brett¹, Schroeder, Mark², Ballman, Karla³, James, C. David², ¹ Department of Oncology, Rochester, MN, USA² Department of Pathology, Rochester, MN, USA³ Department of Biostatistices, Rochester, MN, USA
(PP170) EGFR amplification does not correlate with radiation response of GBM xenografts.

Schaue, Dorthe^*,1, Liao, Yu-Pei¹, Comin-Anduix, Begonya², Ribas, Antoni², Debucquoy, Annelies³, Haustermans, Karin³, McBride, William¹, ¹ Department of Radiation Oncology, Los Angeles, CA, USA² Department of Surgery, Division of Surgical Oncology, Los Angeles, CA, USA³ Department of Radiation Oncology, Leuven, V.Brabant, Belgium
(PP171) The effect of radiation therapy on tumor-specific immune responses.

Schnarr, Kara ^*,1, Dayes, Ian², Sathya, Jinka², McFarlane, Nicole¹, Boreham, Douglas¹, ¹ Medical Physics and Applied Radiation Sciences, Hamilton, ON, CANADA² Department of Radiation Oncology, Hamilton, ON, CANADA
(PP172) Radiation - induced apoptosis of lymphocytes to predict normal tissue late toxicity from radiotherapy.

Scott, Simon^*,1, Greco, Olga ², Murdoch, Craig¹, Lewis, Claire¹, ¹ Division of Genomic Medicine, Sheffield, S. Yorks, United Kingdom² Division of Clinical Sciences, Sheffield, S. Yorks, United Kingdom
(PP173) Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages.

Seed, T^*,1, Inal , C², Deen , J², Aguilar, K¹, ¹ Vitreous State Laboratory, Washington, DC, USA² Radiation Casualty Management, Bethesda, MD, USA
(PP174) Radioprotective effects of low dose amifostine prophylaxis on hematopoietic tissues.

Shah, Pratish^*,1, Shajahan, Shahin¹, Shareef, Mohammed¹, Samayoa, Luis², Kudrimoti, Mahesh¹, Rowland, Randall³, Mohiuddin, Mohammed¹, Ahmed, Mansoor¹, ¹ Department of Radiation Medicine, Lexington, KY, USA² Department of Pathology, Lexington, KY, USA³ Department of Surgery (Division of Urology), Lexington, KY, USA
(PP175) Detection of PSA and Cytokeratin positive prostate tumor cells in post-brachytherapy peripheral blood samples by real-time quantitative RT-PCR and Flow Cytometry.

Nichols, Karen^*,1, Crouse, David^*,1, Sharp, John^*,1, ¹ School of Allied Health Professions, College of Medicine, Omaha, Nebraska, U.S.A.
(PP176) Evaluation of a radiation biology course taught in a computer-based distance learning accessible format.

Shi, Lei^*,1, Sonntag, William², Carter, Christy², Robbins, Michael ³, Long, Ashley¹, Bennett, Colleen ², Brunso-Bechtold, Judy¹, ¹ Department of Neurobiology and Anatomy, Winston-Salem, NC² Department of Physiology and Pharmacology, Winston-Salem, NC³ Department of Radiation Oncology, Winston-Salem, NC
(PP177) Whole brain irradiation leads to cognitive impairment in Fischer 344 X Brown Norway rats.

Siddiqui, Farzan^*,1, Avery, Paul², LaRue, Susan¹, Hauck, Marlene ³, Dewhirst, Mark⁴, Li, Chuan- Yuan⁴, Ullrich, Robert¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Department of Microbiology, Immunology and Pathology, CO, Fort Collins, CO, USA³ Department of Clinical Sciences, Raleigh, NC⁴ Department of Radiation Oncology, Durham, NC, USA
(PP178) A Phase I Hyperthermia- induced Interleukin- 12 gene- therapy trial in spontaneously arising feline soft tissue sarcomas.

Singh, Vijay^*,1, Shafran, Randi¹, Sree Kumar, K¹, ¹ Radiation Casualty Management Team, Bethesda, MD, USA
(PP179) Induction of hematopoietic cytokines and chemokines by radioprotectant tocols.

Smith, Pameeka^*,1, Zhao, Weiling ¹, Robbins, Mike, ¹ Brain Tumor Center of Excellence & Department of Radiation Oncology, Winston-Salem, NC, USA
(PP180) Targeting antioxidant enzymes in anti-glioma therapies.

Singh, Vijay¹, Shafran, Randi¹, Hieber, Kevin¹, Seed, Thomas¹, Sree Kumar, K.¹, ¹ Radiation Casualty Management Team, Bethesda, MD
(PP181) Radioprotective efficacy and cytokine profile induced by a novel radioprotectant, ON01210.

Stieber, Volker^*,1, Robbins, Michael ¹, Balamucki, Christopher³, de Guzman, Alan¹, Tatter, Stepehn², Ekstrand, Kenneth¹, Munley, Michael¹, Branch, Charles², Shaw, Edward¹, Bourland, J.², Lovato, James⁴, Ellis, Thomas², ¹ Wake Forest University, Winston-Salem, NC, United States³ Wake Forest University, Winston-Salem, NC, United States² Wake Forest University, Winston-Salem, NC, United States⁴ Wake Forest University, Winston-Salem, NC, United States
(PP182) Calculation of repair half-time of the trigeminal nerve after gamma knife radiosurgery (GKRS) using clinical data from 256 procedures for trigeminal neuralgia.

Sultanov, Marianna^*,1, Mohiuddin, Mohammed¹, Ahmed, Mansoor¹, ¹ Radiation Medicine, Lexington, KY, USA
(PP183) Effect of high-dose spatially fractionated GRID radiation on regression of distant human lung tumor xenografts.

Hou, Huagang¹, Khan, Nadeem¹, Yu, Hongsheng¹, Demidenko, Eugene¹, O'Hara, Julia¹, Swartz, Harold^*,1, ¹ EPR Center for the Study of Viable Systems, Hanover, NH, USA
(PP184) Observation of increase of oxygen in experimental murine tumors approximately 20 minutes after x-ray irradiation.

Du, Min¹, Zhou, Xinhui¹, Ramdas, Latha¹, Allard, John², Peltz, Gary², Travis, Elizabeth^*,1, ¹ Experimental Radiation Oncology/Radiation Oncology, Houston, TX, USA² Genetics and Genomics, Palo Alto, CA, USA
(PP185) The biological pathways for radiation-induced lung injury in mice.

Trncic, Nadira ^*,1, Kraft, Susan¹, Dewhirst, Mark², LaRue, Susan¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, Colorado, USA² Department of Radiation Oncology, Durham, Nort Carolina, USA
(PP186) Tumor microenvironment and reoxygenation.

Mason, Kathy¹, Valdecanas, David^*,, Neal, Robert, Hunter, Nancy, Ang, Kian², Milas, Luka, ¹ Experimental Radiation Oncology, Houston, TX, USA² Radiation Oncology, Houston, TX, USA
(PP187) CpG oligodeoxynucleotides (CpG ODNs) enhance response of murine tumors to docetaxel.

Buckley, Michael¹, Emmolo, Joanna¹, Devitt, Mary¹, Roth, Jennifer¹, Dewyngaert, J Keith¹, Peter, Brooks², Liebes, Leonard^1,3, Formenti, C Silvia^1,3, Vlachaki, Maria Theodoros^*,1, ¹ Radiation Oncology, New York, NY, USA² Cell Biology, New York, NY, USA³ New York University Cancer Institute, New York, NY, USA
(PP188) Para-aminobenzoic acid (PABA) and high radiation dose rates modulate response to ionizing radiation in experimental lung cancer models.

Wachsberger, Phyllis ^*,1, Burd, Randy¹, Marrero, Nichol¹, Rossetti, Dianne¹, Strickler, Tara ¹, Yancopoulos, George², Holash, Jocelyn², Dicker, Adam¹, ¹ Department of Radiation Oncology, Philadelphia, PA, USA² Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA
(PP189) Improvement of fractionated radiation therapy by combination with a VEGF blocker, VEGF Trap.

Wang, Junru^*,1, Qiu, Xiaohua¹, Kulkarni, Ashwini¹, Hauer-Jensen, Martin¹, ¹ Arkansas Cancer Research Center, Little Rock, AR
(PP190) Regulation of the acute intestinal radiation response by calcitonin gene-related peptide (CGRP) and substance P (SP).

Mayr, Nina¹, Nag, Subir¹, Montebello, Joseph¹, Gupta, Nilendu¹, Kanellitsas, Christos¹, Samsami, Nina¹, Wang, Jian¹, ¹ Department of Radiation Medicine, Columbus, OH, USA
(PP191) Effect of edema, relative biological effectiveness and dose heterogeneity on prostate brachytherapy.

Wang, Tao^*,1,2, Languino, Lucia^2,3, FitzGerald, Thomas^1,4, ¹ Univ. of Massachusetts Medical School, Worcester, MA, United States² Univ. of Massachusetts Medical School, Worcester, MA, United States³ Univ. of Massachusetts Medical School, Worcester, MA, United States⁴ Univ. of Massachusetts Medical School, Worcester, MA, United States
(PP192) Low dose ionizing radiation does not affect the expression of 1 integrin and EGF receptor in DU-145 and PC3 prostate cancer cells.

Wang, Zhong-He^*,1, Wang, Ming-Guo¹, Hu, Hai-Sheng¹, ¹ Shanghai Second Medical University, Shanghai, China
(PP193) Enhanced anit-tumor effect of mab225 in combination with radiation for humon tongue squamous cell carcinoma cell line.

Welsh, James^*,1, ¹ University of Wisconsin-Madison, Wisconsin Rapids, WI, USA
(PP194) Periodic irradiation from the cosmos over geologic history: potential biological impact.

Whitehead, Timothy ^*,1, Deasy, Joseph ¹, Roti Roti, Joseph ¹, ¹ Radiation Oncology, St Louis, MO, USA
(PP195) Simulating tumor response to fractionated radiotherapy using a bioreactor.

Wiedenmann, Nicole^{*,1, 2}, Neal, Robert¹, Hunter, Nancy¹, Raju, Uma¹, Milas, Luka¹, Mason, Kathy¹, ¹ Department of Experimental Radiation Oncology, Houston, TX, USA² Department of Radiation Oncology, Munich, D, Germany
(PP196) In vivo interaction of single dose radiation with G3139, a Bcl-2 antisense oligonucleotide.

Wlodarczyk, Waldemar^*,1, Gellermann, Johanna¹, Nadobny, Jacek¹, Felix, Roland ¹, Wust, Peter¹, ¹ Charite Medical University, Berlin, Germany
(PP197) Magnetic resonance monitoring of temperature distributions in patients undergoing regional hyperthermia: accuracy and guidance in clinical routine.

Hossain, Moazzem¹, Atkinson, Shelley¹, Li, Yu Qing¹, Wong, Shun^*,1, ¹ Radiation Oncology, Toronto, Ontario, Canada
(PP198) Systemically administered erythropoietin protects the irradiated brain through anti-inflammatory mechanisms.

Mocanu, Joseph¹, Au, P. Y.², Sleep, Gillian¹, Yeh, Wen-Chen², Gilbert, Ralph³, O Sullivan, Brian⁴, Gullane, Patrick³, Bastianutto, Carlo¹, Liu, Fei-Fei^1,4, Yip, Kenneth^*,1, ¹ Applied Molecular Oncology, Toronto, ON, Canada² Advanced Medical Discovery Institute, Toronto, ON, Canada³ Surgical Oncology, Toronto, ON, Canada⁴ Radiation Oncology, Toronto, ON, Canada
(PP199) Combination Bcl-2 antisense and radiation therapy for nasopharyngeal cancer.

Yong, Kwon-Joong^*,1, Velena, Alfredo ¹, Chen, Bin², Petukhov, Pavel², Kozikowski, Alan², Dritschilo, Anatoly ¹, Jung, Mira¹, ¹ Department of Radiation Medicine, Lombadi Cancer Center, Washington, D.C., USA² Department of Medical Chemistry and Pharmacognosy, Chicago, IL, USA
(PP200) Identification of Novel HDAC Inhibitors with Radiosensitizing Properties.

Song, Jie-Young ¹, Lim, Hee-Soon ¹, Kim, Hyung-Doo , Han, Youngsoo¹, Son, Hyeog-Jin ¹, Yun, Yeon-Sook¹, ¹ Laboratory of Radiation Immunology, nowon-ku, Seoul, Republic of Korea
(PP201) Development of biomarkers in radiation-induced lung damages.

Cell and Tissue Signaling

Albanese, Joseph ^*,1, Dainiak, Nicholas^{2, 3}, ¹ Center for Emergency Preparedness and Disaster Response, New Haven, CT, USA² Department of Medicine, Bridgeport, CT³ Yale University School of Medicine, New Haven, CT, USA
(PP202) Ionizing radiation (IR)-induced transcriptional and translational up-regulation of TNFRSF6 and TNFSF6 in a human bone marrow stromal cell line: Potential biomarkers for radiation exposure.

Andarawewa, Kumari ^*,1, Erickson, Anna ¹, Chou, William ¹, Bissell , Mina ¹, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer biology, berkeley, CA, USA
(PP203) Ionizing radiation predisposes human mammary epithelial cells to TGF induced epithelial to mesenchymal transition.

Ansari, Ramin^*,1, Gaber, M.Waleed ², Wang, Bin¹, Kiani, Mohammad ¹, ¹ Departments of Mechanical Engineering and Radiation Oncology, Philadelphia, PA, USA² Department of Biomedical Engineering, Memphis, TN, USA
(PP204) Radiation-induced bystander effect in normal brain tissue.

Anzenberg, Vered^*,1, Yang, Hongying¹, Held, Kathryn¹, ¹ Radiation Oncology, Charlestown, MA, USA
(PP205) Bystander effect by medium mediated intercellular communication after x-ray and Fe ion beam irradiation in human keratinocytes.

Milliat, Fabien^{*,1, 2}, François, Agnès^{*,1, 2}, Isoir, Muriel^*,1, Sabourin, Jean-Christophe^*,3, Benderitter, Marc ^*,1, ¹ Laboratory of Radiopatholgy, Fontenay aux Roses, France² UPRES EA2710 Radiosensitivity of tumor and normal tissues, Villejuif, France³ Department of Pathology, Villejuif, France
(PP206) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation.

Blakely, Eleanor ^*,1, Schwarz, Richard¹, Thompson, Al², Bjornstad, Kathleen¹, Chang, Polly^{1, 4}, Rosen, Chris¹, Sudar, Damir¹, Romano, Raquel³, Parvin, Bahram³, ¹ Life Sciences Division, Berkeley, CA, USA² Advanced Light Souce Division, Berkeley, CA, USA⁴ Biosciences Division, Menlo Park, CA, USA³ Computational Research Division, Berkeley, CA
(PP207) X-ray microbeam bystander studies with human mammary epithelial cells and fibroblasts.

Boerma, Marjan^*,1, Kennedy, Richard², Kulkarni, Ashwini¹, Joseph, Jacob³, Wondergem, Jan⁴, Wang, Junru¹, Hauer-Jensen, Martin¹, ¹ Departments of Surgery and Pathology, Little Rock, AR, USA² Loyola University Medical Center, Maywood, IL, USA³ Cardiology Section, West Roxbury, MA, USA⁴ Leiden University Medical Center, Leiden, NL, The Netherlands
(PP208) Interactions between mast cells and the endothelin system in radiation-induced heart disease.

Burrell, Cheryl^*,1, Ortloff, Leticia², Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, California, U.S.A.² Radiobioloy Program - Radiation Medicine, Loma Linda, California, U.S.A.³ Research, Loma Linda, California, U.S.A.
(PP209) The role of TGF-beta 1 as a result of repeated subculturing and radiation in FRTL-5 cells.

Cai, Xu Wei^*,1, Fu, Xiao Long¹, ¹ Fudan University Cancer Hospital, Shanghai, China
(PP210) Inhibiting the effects of TGF-1 on increasing collagen formation in fibroblast: the application of replication-defective adenovirus containing radio-inducible Egr-1 promoter and smad7 cDNA under ionizing radiation.

Wang, Rong^{1, 2}, Coderre, Jeffrey^*,1, ¹ Department of Nuclear Science and Engineering, Cambridge, MA, USA² Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA
(PP211) A bystander effect in alpha-particle irradiations of human prostate tumor cells.

Collins-Underwood, J. Racquel^{*,1, 2}, Zhao, Weiling¹, Kooshki, Mitra¹, Robbins, Michael¹, ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC, USA² Department of Cancer Biology, Winston-Salem, NC
(PP212) Role of NADPH oxidase in radiation-induced brain injury.

Cook, John^*,1, Chuang, Yao-Yu¹, Coffin, Deborah¹, DeGraff, William¹, Zhao, Shuping¹, Yan, Hailing¹, Cherukuri, Murali¹, Mitchell, James¹, ¹ Radiation Biology Branch, Bethesda, MD, USA
(PP213) Comparison of gene regulation by nitroxides, hydrogen peroxide, t-butylhydroperoxide, and menadione using microarray time analysis.

Storck, Christopher¹, Vemuri, Srinath¹, Leeper, Dennis, Coss, Ronald^*,1, ¹ Department of Radiation Oncology, Philadelphia, PA, USA
(PP214) The phosphorylated state of Hsp27 in human melanoma cells following thermal therapy.

Crosby, Meredith ^{*,1, 2}, Jacobberger, James¹, Macklis, Roger ³, Almasan, Alexandru^{2, 3}, ¹ Department of Environmental Health Sciences, Cleveland, OH, USA² Department of Cancer Biology, Cleveland, OH, USA³ Department of Radiation Oncology, Cleveland, OH, USA
(PP215) E2F4/p130 complexes serve as critical regulators of the ionizing radiation-induced G2 cell cycle arrest.

Fisher, Carolyn^*,1, Goswami, Prahbat¹, ¹ Free Radical and Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA, USA
(PP216) Increased radioresistance and G2 delay in manganese superoxide dismutase overexpressing human pancreatic cancer cells.

Freyer, James^*,1, Albertini, Rebecca¹, Guerra, Anabel¹, ¹ Bioscience Division, Los Alamos, NM, USA
(PP217) A new model of the tumor microenvironment.

Glazer, Peter^*,1, Bindra, Ranjit¹, ¹ Department of Therapeutic Radiology, New Haven, CT, USA
(PP218) Dysregulation of DNA repair genes in hypoxia.

Greenberger, Joel^*,1, Zhang, Xichen¹, Hricisak, Lauren¹, Epperly, Michael¹, ¹ Radiation Oncology/Medicine, Pittsburgh, PA, USA
(PP219) Absence of the Smad3 gene product increases radiation resistance of bone marrow stromal cells.

Howe, Orla^*,1, White, Christine¹, McClean, Brendan², Lyng, Fiona¹, ¹ Radiation and Environmental Science Centre, Focas Institute, Dublin, Dublin, Ireland²
(PP220) Correlation of intrinsic radiosensitivity with bystander factor production.

Jackson, Isabel^*,1, Batinic-Haberle, Ines¹, Sonveaux, Pierre¹, Vujaskovic, Zeljko¹, ¹ Duke University Medical Center, Durham, NC, United States
(PP221) Hypoxia induced production of ROS by macrophages is associated with TGF-activation.

Johnke, Roberta^*,1, Smith, Elizabeth¹, Kovacs, Charles¹, Evans, Mark¹, Cariveau, Mickael¹, Allison, Ron¹, ¹ Department of Radiation Oncology, Greenville, NC, USA
(PP222) Radioprotection of the murine gastrointestine by IL-1 involves downregulation of apoptotic caspases.

Balfour, Eric², Singh, Anu², Jolly, Puneet^*,1, Velana, Alfredo¹, Jung, Mira¹, Gagnon, Gregory^1,2, ² Georgetown University Hospital, Washington, DC, United States¹ Georgetown University School of Medicine, Washington, DC, United States
(PP223) In vitro comparison of CyberKnife® stereotactic radiosurgery and standard external-beam radiotherapy.

Kadhim, Munira^*,1, Kelly, James¹, Moor, Stephen¹, Smyth, Sharon¹, Goodwin, Edwin², ¹ Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK² Biosciences Division, Los Alamos, New Mexico, USA
(PP224) Comparison of initial and long term damage in irradiated and bystander populations.

Kassis, Amin^*,1, Kishikawa, Hiroko¹, Wang, Ketai¹, Adelstein, S. James¹, ¹ Department of Radiology, Boston, MA
(PP225) Inhibitory (¹²⁵I) and stimulatory (¹²³I) bystander effects produced by radiolabeled tumor cells: in vitro and in vivo studies.

Khodarev, Nikolai^*,1, Labay, Edwardine¹, Darga, Thomas, Beckett, Michael¹, Mauceri, Helena ¹, Halpern, Arielle¹, Bickenbach, Kai ², Veerapong, Jula², Schmidt, P. Henry², Bernard, Roizman³, Weichselbaum, Ralph¹, ¹ Department of Radiation and Cellular Oncology, Chicago, IL, USA² Department of Surgery, Chicago, IL, USA³ Marjorie B. Kovler Viral Oncology Laboratories, Chicago, IL, USA
(PP226) Stat1 dependent pathway as a mediator of tumor response to ionizing radiation and integrator of ionizing radiation and interferon induced pathways.

Kim, Kwanghee^*,1, Iwamoto, Kei¹, McBride, William¹, ¹ Radiation Oncology, Los Angeles, CA, U.S.A.
(PP227) Proteasomal subunit composition of U87 cells is altered by irradiation.

Kirshner, Julia^*,1, Barcellos-Hoff, Mary Helen ¹, ¹ Cancer Biology/Life Sciences, Berkeley, CA
(PP228) TGF1 signaling mediates ATM and its downstream target activation in response to ionizing radiation.

Bi, Meixia¹, Naczki, Christine ¹, Fels, Diane ¹, Koritzinsky, Marianne ², Wouters, Bradly², Koumenis, Constantinos^*,1, ¹ Radiation Oncology, WInston-Salem, NC, USA² Radiotherapy, Maastricht, 6200, Netherlands
(PP229) An ER stress-regulated translational control program confers hypoxia tolerance and promotes tumor growth.

Guo, Chang ^*,1, Brautigan, David², Larner, James^*,1, ¹ Dept. of Radiation Oncology, Charlottesville, VA, USA² Center for Cell Signaling, Charlottesville, VA, USA
(PP230) IR inhibits centrosome separation through Nek2 and PP1.

Kwon, Seok¹, Song, Jae¹, Lee, Yong^*,1, ¹ Department of Surgery, Pittsburgh, PA, USA
(PP231) HIF-1 phosphorylation and its role in the interaction with pVHL.

Lee, Yoon-JIn^*,1, Kim, Dae-Yong¹, Chung, Da Yeon ¹, Bae, Sang-Woo¹, Lee, Su-Jae², Lee, Dae-Hoon¹, Jhon, Gil-Ja³, Lee, Yun-Sil¹, ¹ Laboratory of Radiation Effect, Seoul, Gongneugdong, Korea² Laboratory of Experimental Radiation Therapeutics, Seoul, Gongneugdong, Kores³ Division of Molecular Life Science, Seoul, Daehundong, Korea
(PP232) Enhanced radiosensitization by oleamide in p53 mutant cells.

Seo, Haeng Ran¹, Lee, Dae-Hoon ¹, Bae, Sangwoo¹, Soh, Jae-Won ², Lee, Yun-Sil ¹, ¹ Laboratory of Radiation Effect, Seoul, Nowon-Gu, Korea² Laboratory of Signal Transduction, Incheon, Nam-Gu, Korea
(PP233) Cyclin G1 dacilitates radiation-induced G2-M transition and cell death through transcriptional activation of Cyclin B1.

Giedzinski, Erich¹, Baure, Jennifer¹, Rola, Radoslaw², Fike, John^{1, 2}, Limoli, Charles^*,1, ¹ Radiation Oncology, San Francisco, CA² Neurological Surgery, San Francisco, CA
(PP234) Modifying the radioresponse of neural precursor cells through changes in oxidative stress.

Liu, Zhengfeng^*,1, Prestwich, William¹, Byun, Soo Hyun¹, Mothersill, Carmel¹, McNeill, Fiona¹, Seymour, Collin¹, ¹ Medical Physics and Applied Radiation Sciences, Hamilton, Ontario, Canada
(PP235) The study of low-dose accelerator based neutrons for bystander effects.

Gupta, Damodar ¹, Thakkar, Vipul ², Almasan, Alex³, Macklis, Roger⁴, ¹ Cancer Biology and Radiation Oncology, Cleveland, Ohio, USA² Radaition Oncology, Cleveland, Ohio, USA³ Cancer Biology, Cleveland, Ohio, USA⁴ Radiation Oncology, Cleveland, Ohio, USA
(PP236) Increased expression of CD20 and associated transcription factors by low dose radiation.

Mukherjee, Abhik¹, Martin, Stewart^*,1, ¹ University of Nottingham, Dept of Clinical Oncology, Nottingham, Notts, UK
(PP237) Targeting the thioredoxin system with AW464: hypoxic cytotoxicity, antiangiogenic activity and chemo-/radiosensitisation.

Maslowski, Amy^*,1, Ford, John¹, Braby, Lesley¹, ¹ Nuclear Engineering, College Station, TX, USA
(PP238) Low dose radiation interactions with the TGF- pathway through ECM components.

Meyer, Joshua^*,1, Fitzgerald, T², Altieri, Dario¹, ¹ Department of Cancer Biology, Worcester, MA, USA² Department of Radiation Oncology, Worcester, MA, USA
(PP239) Irradiation upregulates EGFR and survivin in non small cell lung cancer cells.

Mohiuddin, Majid^*,1, Held, Kathryn¹, ¹ Radiation Oncology, Boston, MA, USA
(PP240) Bystander effect on p53 wild-type and mutant colon cancer cell lines at low radiation doses.

D'Cruz, Genevieve^{1, 2}, Gius, David ^{1, 4}, Morgan, William^{1, 2, 3}, ¹ Molecular and Cell Biology Graduate Program, Baltimore, Maryland, USA² Department of Radiation Oncology, Baltimore, Maryland, USA⁴ Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA³ Marlene and Stewart Greenbaum Cancer Center, Baltimore, Maryland, USA
(PP241) Role of molecular chaperone Bag-3/ CAIR-1 in the regulation of Akt and its related proteins following irradiation.

Natarajan, Mohan ^*,1, Mohan, Sumathy², Gibbons, Catherine³, Kadhim, Munira⁴, ¹ Department of Radiation Oncology, San Antonio, Texas, USA² Department of Pathology, Saqn Antonio, Texas, USA³ Environmental Toxicology Graduate Program, Riverside, CA, USA⁴ Radiation and Genomic Stability Unit, Didcot, Oxfordshire, UK
(PP242) Soluble factor mediated bystander response from irradiated human smooth muscle cells to unirradiated endothelium.

O'Dowd, Colm ^*,1, Mothersill, Carmel², Cairns, Micheal³, Austin, Brian⁴, Murphy, James¹, ¹ Radiation and Environmental Science Centre, Dublin, Ireland, Ireland.² School of Medical Physics and Applied Radiation Science, Hamilton, Ontario, Canada.³ Gene Regulation Group, Galway, Ireland, Ireland⁴ School of Life Sciences, Edinburgh, Scotland, UK
(PP243) An investigation of altered cellular response of the epithelioma papillosum cyprinii (EPC) cell line to media from irradiated tissue of rainbow trout (Oncorhynchus mykiss).

Oancea, Marcela^{*,1, 2}, Singhi, Aatur Singhi³, Chumakov, Peter ³, Gudkov, Andrei ³, Almasan, Alex ^{2, 4}, ¹ Department of Chemistry, Cleveland, OH, USA² Department of Cancer Biology, Cleveland, OH, USA³ Department of Molecular Genetics, Cleveland, OH, USA⁴ Department of Radiation Oncology, Cleveland, OH, USA
(PP244) The role of puma, a BH3-only protein, in radiation induced apoptosis.

Oh, Haejin^*,1, Seong, Jinsil¹, An, Jeunghee¹, Kim, Wonwoo¹, ¹ Radiation Oncology, Brain Korea 21 project for Medical Sciences, Seoul, Korea, Korea, south
(PP245) Proteomic analysis for regulation of radiation-induced apoptosis in murine tumors.

Okabe, Atsushi^{1, 2}, Takakura, Kaoru², Okayasu, Ryuichi¹, ¹ International Space Radiation Laboratory, Chiba, Chiba, Japan² Division of Natural Sciences, Mitaka, Tokyo, Japan
(PP246) The autophosphorylation of DNA-PKcs in irradiated human cells.

Pandey, Badri^{*,1, 2}, Gordon, Donna³, de Toledo, Sonia¹, Pain, Debkumar³, Azzam, Edouard¹, ¹ Department of Radiology, Newark, NJ, USA² Radiation Biology and Health Sciences Division, Mumbai, MH, India³ Department of Pharmacology and Physiology, Newark, NJ, USA
(PP247) Low and high dose ionizing radiation differentially modulate mitochondrial function in normal human cells and their progeny.

Pandya, Pinal^*,1, Bianski, Brandon², Ortloff, Leticia², Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, CA, USA² Radiobiology Program-Radiation Medicine, Loma Linda, CA, USA³ Research, Loma Linda, CA, USA
(PP248) Radiation-induced alteration of protein kinase C expression in thyroid follicular cells.

Perez-Nunez, Delia^*,1, Ford, John ¹, Braby, Leslie¹, ¹ NUCLEAR ENGINEERING, COLLEGE STATION, TEXAS, USA
(PP249) Effects in PKcs suppressed AG 1522 cells.

Plesca, Dragos^{*,1, 2}, Mazumder, Suparna¹, Almasan, Alex^{1, 2, 3}, ¹ Department of Cancer Biology, Cleveland, OH, USA² School of Biomedical Sciences, Kent, OH, USA³ Department of Radiation Oncology, Cleveland, OH
(PP250) The interaction of the proteolytic fragment of Cyclin E with Ku70 enhances apoptosis by inhibiting DNA repair.

Portess, Daniel ^*,1, Hill, Mark¹, Bauer, Georg², O'Neill, Peter¹, ¹ Radiation and Genome Stability Unit, Didcot, Oxfordshire, United Kingdom² Abteilung Virologie, Freiburg, Breisgau, Germany
(PP251) Radiation induced signalling leads to apoptotic response in transformed cells: involvement of cytokines and ROS.

Qutob, Sami^*,1, Lachapelle, Sylvie², Thorleifson, Erika¹, Segura, Tamika², Mullins, Dana², Prud'homme-Lalonde, Louise, Wilkinson, Diana², ¹ Consumer and Clinical Radiation Protection Bureau, Ottawa, Ontario, Canada² Radiological Analysis and Defence, Ottawa, Ontario, Canada
(PP252) Identification of radiation responsive biomarkers using a rotary bioreactor to simulate an in vivo environment.

Aguilera, Joe³, Chou, David², Milligan, Jamie², Zhang, Lingxiao³, Lee, Guk Haeng⁵, Yoo, Hyung Jun⁴, Pardo, Francisco^2,3, Rajni, Sethi^*,1, ³ Moores Cancer Center, San Diego, CA, USA² Department of Radiation, San Diego, CA, USA⁵ Department of Otolaryngology, Korea, South Korea⁴ Department of Radiation Oncology, Seoul, South Korea¹ School of Medicine, San Diego, CA, USA
(PP253) Cyclin E modulates radiation sensitivity by altering the function of cell cycle checkpoints and DNA repair in glioblastoma cells.

Rithidech, K. Noy^*,1, Honikel, Louise¹, Rieger, Robert², Xie, Weiping², Fischer, Thomas², Simon, Sanford¹, ¹ Pathology, Stony Brook, NY, USA² Proteomics Center, Stony Brook, NY
(PP254) Analysis of protein expression profiles in blood plasma of mice acutely exposed whole body to ionizing radiation.

Rola, Radoslaw^*,1, Fike, John^{1, 2}, Fishman, Kelly¹, Limoli, Charles², ¹ Dept. of Neurosurgery, San Francisco, CA, USA² Department of Radiation Oncology, San Francisco, CA, USA
(PP255) Persistent oxidative stress impairs hippocampal neurogenesis and increases sensitivity of neuronal precursor cells to radiation.

Sanchez, Martha^*,1, Ortloff, Leticia ², Green, Lora^{1, 2, 3}, ¹ Department of Physiology & Pharmacology, Loma Linda, CA, USA² Radiobiology Program, Loma Linda, CA, USA³ Research, Loma Linda, CA, USA
(PP256) Effects of low dose radiation exposure on glutamate transporter expression and neurotoxicity.

Santi, Stacey^{*,1, 2}, Lee, Hoyun ^{1, 2}, ¹ University of Ottawa, Ottawa, Ontario, Canada² Northeastern Ontario Regional Cancer Centre (NEORCC), Sudbury, Ontario, Canada
(PP257) The Akt/PKB survival pathway: a role for isoform specificity in breast cancer.

Segura, Tamika^*,1, Prud'homme-Lalonde, Louise¹, Lachapelle, Sylvie¹, Mullins, Dana¹, Qutob, Sami², Thorleifson, Erika², Lemyre, Louise³, Wilkinson, Diana¹, ¹ Radiological Analysis & Defence;, Ottawa, Ontario, Canada² Consumer and Clinical Radiation Protection Bureau;, Ottawa, Ontario, Canada³ Institute of Population Health;, Ottawa, Ontario, Canada
(PP258) Biomarkers of radiation exposure and stress based on individual responsiveness.

Semenenko, Vladimir^*,1, Dong, Shaozhong¹, Fan, Ming¹, Ahmed, Kazi¹, Li, Jian Jian ¹, ¹ Divisioin of Moledcular Radiobiology, West Lafayette, Indiana, USA
(PP259) NF-kappaB mediated signaling network in the radioresistance of human breast cancer cells.

Seong, Jinsil^*,1, An, Jeunghee¹, Oh, Haejin¹, ¹ Radiation Oncology, Brain Korea 21 project for Medical Sciences, Seoul, Korea, Korea, south
(PP260) Regulation of radiation-induced apoptosis in murine tissues; proteomic analysis.

Serra, Virginia^*,1, Ortloff, Leticia², Jobe, Marlene², Pandya, Pinal¹, Green, Lora^{1, 2, 3}, ¹ Department of Microbiology, Loma Linda, Ca, USA² Radiobiology Program-Radiation Medicine, Loma Linda, Ca, USA³ Research, Loma Linda, CA, USA
(PP261) Radioprotective effects of a super oxide dismutase mimetic on V79-4 micronucleus formation and survival.

Shareef , Mohammed^*,1, Ahmed, Mansoor¹, ¹ Radiation Medicine, Lexington, Kentucky, USA
(PP262) Novel mechanism of regulation of TGF- signaling pathway as a function of oxygen concentration and ionizing radiation exposure of pancreatic carcinoma cells.

Fan, Feiyue¹, Yue, Jingyin¹, Liu, Zheng¹, Zhao, Minghui¹, Zhan, Qimin¹, Shen, Zhiyuan², ¹ Radiation Biology, Tianjin, TJ, China² Molecular Genetics & Microbiology, Albuquerque, NM, USA
(PP263) Function and regulation of ATF3 expression induced by ionizing radiation.

Sitko, John^*,1, McBride, William¹, ¹ Radiation Oncology, Los Angeles, CA, USA
(PP264) Suppressors of cytokine signaling as modulators of radiation response.

Sokolov, Mykyta^*,1, Smirnova, Nataliya², Camerini-Otero, Daniel², Panyutin, Igor¹, Neumann, Ronald¹, ¹ Department of Nuclear Medicine, Bethesda, MD, US² Genetics and Biochemistry Branch and Laboratory of Cellular and Developmental Biology, Bethesda, MD, US
(PP265) Genome-wide changes in gene expression in primary human fibroblasts in response to I-125-induced DNA damage.

Springer, David^*,1, Ahram, Mamoun¹, Kathmann, Loel¹, Miller, John², ¹ Biological Sciences Division, Richland, WA, USA² Computer Science, Richland, WA, USA
(PP266) Protein changes in media conditioned by irradiated CHO cells.

Story, Michael^*,1, Ang, Kian², Ramdas, Latha³, Giri, Uma³, Ashorm, Cheryl ³, Stivers, David⁴, Coombes, Kevin⁴, El-Naggar, Adel⁵, ¹ Molecular Radiation Biology, Dallas, TX, USA² Radiation Oncology, Houston, TX, USA³ Experimental Radiation Oncology, Houston, TX, USA⁴ Biostatistics and Applied Mathematics, Houston, TX, USA⁵ Pathology, Houston, TX, USA
(PP267) Determining a molecular signature for metastasis from the primary tumors of patients with head and neck squamous cell carcinoma.

Sturla, Lisa-Marie^*,1, Amorino, George¹, Alexander, Michael¹, Mikkelsen, Ross¹, Valerie, Kristoffer¹, Schmidt-Ullrich, Rupert¹, ¹ Radiation Oncology, Richmond, VA, USA
(PP268) Requirement of Tyr992 and Tyr1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2.

Sun, Yingli^*,1, Price, Brendan¹, ¹ Radiation Oncology, Boston, MA, USA
(PP269) Tip60 Histone Acetyltransferase regulates the acetyaltion and activation of ATM following DNA damage.

Yang, Hyun Sook¹, Lee, Seung Bum¹, Um, Hong-Duck^*,1, ¹ Laboratory of Radiation Tumor Physiology, Seoul, Korea, Korea
(PP270) JNK-dependent ROS production in mitochondria: its role in gamma-ray-induced cell death.

Wang, Yong^*,1, Schulte, Bradley¹, Zhou, Daohong¹, ¹ Department of Pathology and Lab Medicine, Charleston, SC, USA
(PP271) Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Wang, Tao ^{*,1, 2, 4}, Languino, Lucia^{2, 3, 4}, FitzGerald, Thomas^{1, 4}, ¹ Radiation Oncology, Worcester, MA, USA² Cancer Biology, Worcester, MA, USA⁴ Cancer Center, Worcester, MA, USA³ Cell Biology, Worcester, MA, USA
(PP272) Insulin-like growth factor type I receptor (IGF-IR) mediates radioresistance of DU-145 and PC3 human prostate cancer cells during ionizing radiation.

Williams, Dustin¹, Pond, Chris¹, Leachman, Sancy², Warters, Raymond^*,1, ¹ Department of Radiation Oncology, Salt Lake City, UT, USA² Department of Dermatology, Salt Lake City, UT, USA
(PP273) Protein phosphorylation in irradiated human cells.

Weidhaas, Joanne^*,1, Eisenmann, David², ¹ Therapeutic Radiology, New Haven, CT²
(PP274) A C. elegans model of EGFR-mediated treatment resistance to cytotoxic therapy.

Williams, Jacqueline^*,1, Hernady, Eric¹, Johnston, Carl², Reed, Christina², Finkelstein, Jacob², ¹ Radiation Oncology, Rochester, NY, USA² Pediatrics/Neonatology, Rochester, NY, USA
(PP275) An investigation into the relationship between IL-1, IL-1, MCP-1, and radiation late effects in the lung.

Worgul, Basil^*,1, Kleiman, Norman², David, Janice¹, ¹ Eye Radiation & Environmental Reseach, Dept. Ophthalmology, New York, NY, US² Environmental Health Sciences, New York, NY, US
(PP276) A positive and negative bystander effect influences cataractogenesis in lenses exposed to low doses of x-rays.

Natarajan, Mohan ¹, Nallathamby, Prakash², Xu, Nancy², ¹ Department of Radiation Oncology, San Antonio, Texas, USA² Department of Chemistry and Biochemistry, Norfolk, VA, USA
(PP277) Molecular imaging of TNF-a trafficking from irradiated to un-irradiated cells using silver (Ag) nanoprobes.

Yang, Hongying^*,1, Anzenberg, Vered¹, Held, Kathryn¹, ¹ Department of Radiation Oncology, Boston, MA, USA
(PP278) Comparisons of effects of different charged particles in directly irradiated and bystander normal human fibroblasts.

Yu, Lei^*,1, Domann, Frederick¹, ¹ Free Radical & Radiation Biology, Iowa City, IA, USA
(PP279) GPx-1 inhibits UVA induced AP2 expression in HaCaT cells.

Yu, Yongjia ^*,1, Gao, Yuanyuan¹, Cornforth, Michael¹, Morrill, Steven¹, Gao, Junling², Wu, Ping², ¹ Dept. of Radiation Oncology/Biology Division, Galveston, Texas, USA² Dept. of Neuroscience and Cell Biology, Galveston, Texas, USA
(PP280) Differentiation of grafted human neural stem cells in irradiated rat brain.

Zhao, Weiling^*,1, Kooshki, Mitra¹, Payne, Valerie¹, Robbins, Mike ¹, ¹ Department of Radiation Oncology, Brain Tumor Center of Excellence, Winston-Salem, NC, USA
(PP281) Transthyretin, a cellular defense gene expressed in traumatic brain injury and Alzheimer′s disease, is upregulated 6 months after brain irradiation.

Genomic Maintenance & Repair

Al Rashid, Shahnaz^*,1, Law, Cindy¹, Bristow, Robert^{1, 2}, ¹ Department of Medical Biophysics, Toronto, Ontario, Canada² Department of Radiation Oncology, Toronto, Ontario, Canada
(PP282) The role of p53 carboxy-terminus domains and recruitment to nuclear sites of DNA damage.

Ray, Subrata², Gupta, Damodar^{1, 2}, Macklis, Roger ¹, Almasan, Alex^{*,1, 2}, ² Cancer Biology/Lerner Research Institute, Cleveland, OH¹ Radiation Oncology/Taussig Cancer Center, Cleveland, OH
(PP283) Ionizing radiation-induced G2-checkpoint control by ATR and Chk1 in p53 deficient prostate cancer cells.

Alsbeih, Ghazi^*,1, Al-Harbi, Najla¹, Torres, Martha¹, Al-Buhairi, Muneera¹, Al-Hamed, Mohamed², El-Sebaie, Medhat³, Al-Rajhi, Nasser³, ¹ Biomedical Physics Dept., Riyadh, CR, Saudi Arabia² Aragene, Riyadh, CR, Saudi Arabia³ Radiation Oncology, Riyadh, CR, Saudi Arabia, Saudi Arabia
(PP284) Relationship between protein induction, polymorphisms and radiotherapy complications in Saudi cancer patients.

Bahary, Nathan^*,2, Epperly, Michael¹, Quadar, Mubina¹, Greenberger, Joel¹, ² Molecular Genetics and Biochemistry, Pittsburgh, PA, USA¹ Radiation Oncology, Pittsburgh, PA, USA
(PP285) Small molecule antioxidants prevent ionizing irradiation-induced fibrosis in the adult zebrafish.

Balajee, Adayabalam^*,1, Baskar, Rajamanickam¹, Geard, Charles¹, ¹ Radiation Oncology, New York, NY, USA
(PP286) Histone H2AX is dispensable for base excision repair activity.

Begg, Adrian^*,1, Vermeulen, Christie¹, Vens, Conchita¹, ¹ Experimental Therapy, Amsterdam, NH, Netherlands
(PP287) The role of repair and bypass polymerases in the radiation response.

Bindra, Ranjit^{*,1, 2}, Gibson, Shannon^{1, 7}, Meng, Alice^{5, 6}, Jasin, Maria ³, Pierce, Andrew⁴, Bristow, Robert^{5, 6}, Classon, Marie⁷, Glazer, Peter^{1, 8}, ¹ Department of Therapeutic Radiology, New Haven, CT, USA² Department of Experimental Pathology, New Haven, CT, USA⁷ MGH Cancer Center, Charlestown, MA, USA⁵ Ontario Cancer Institute, Toronto, Ontario, Canada⁶ Department of Medical Biophysics, Toronto, Ontario, Canada³ Molecular Biology Program, New York, NY, USA⁴ Department of Microbiology, Immunology and Molecular Genetics, Lexington, KY, USA⁸ Department of Genetics, New Haven, CT, USA
(PP288) Stress-induced regulation of BRCA1 expression by E2Fs.

Borgmann, Kerstin^*,1, Jend, Camilla¹, Streichert, Thomas², Zschenker, Oliver¹, Stürzbecher, Horst³, Dikomey, Ekkehard¹, ¹ Lab of Radiobiology & Experimental Radiooncology, Clinic of Radiotherapy and Radiooncology, Hamburg, Germany² Institute of Clinical Chemistry, Hamburg, Germany³ Institute of Human Genetics, Luebeck, Germany
(PP289) Drastic changes in gene expression caused by Rad51 overexpression affects DNA repair only in S/G2- but not in the G1-phase.

Chan, Norman^*,1, Meng, Alice¹, Jalali, Farid¹, Bindra, Ranjit², Glazer, Peter², Powell, Simon³, Bristow, Rob¹, ¹ Department of Medical Biophysics, Toronto, Ontario, Canada² Department of Therapeutic Radiology, New Haven, CT, USA³ Department of Radiation Oncology, St. Louis, MO, USA
(PP290) DNA double strand break repair and hypoxia-mediated genetic instability.

Chaudhry, Ahmad^*,1, ¹ Medical Laboratory and Radiation Sciences, Burlington, VT
(PP291) Radiation-induced gene expression profile of human cells deficient in 8-hydroxy-2'-deoxyguanine glycosylase.

Chen, Benjamin^*,1, Kobayashi, Junya², Yajima, Hirihiko ¹, Krempler, Andrea ³, Löebrich, Markus ³, Chen, David¹, ¹ Radiation Oncology/Molecular Radiation Biology, Dallas, TX, USA² Radiation Biology, Hiroshima, Hiroshima, Japan³ Fachrichtung Biophysik, Homburg, Saar, Germany
(PP292) Differential regulation of IR-induced T2609 and S2056 phosphorylation of DNA-PKcs.

Langland, Gregory¹, Guan, Yinghui¹, Yannone, Steven¹, Shingyoji, Masato¹, Long, Sydney¹, Vonguyen, Lien¹, Chen, David¹, Gray, Joe¹, Chen, Fanqing^*,1, ¹ Life Sciences Division, Berkeley, CA, USA
(PP293) Evaluation of p53 and the DNA-dependent protein kinase as predictors of radiation-sensitivity in ovarian cancer cells.

Coleman, Matthew^*,1, Pearson, Francesca¹, Bourguet, Feliza ¹, Jones, Irene¹, Wyrobek, Andrew ¹, Marchetti, Francesco ¹, ¹ Biomedical Division, Biosciences Directorate, Livermore, CA, USA
(PP294) Understanding radiation-modulated proteins: an array based approach.

Datta, Kamal^*,1, Neumann, Ronald¹, Winters, Thomas¹, ¹ Nuclear Medicine Department/ Warren Grant Magnuson Clinical Center, Bethesda, MD
(PP295) Upstream lesions are a more severe impediment to non-homologous end joining than blocked 3′-ends.

Davidson, William^*,1, Kari, Gabor¹, Daroczi, Borbala¹, Rodeck, Ulrich², Dicker, Adam¹, ¹ Radiation Oncology, Philadelphia, Pennsylvania, USA² Dermatology, Philadelphia, Pennsylvania, USA
(PP296) Knock down of p53 suppresses radiation-induced malformations and enhances zebrafish embryo survival.

De Schutter, Harlinde^*,1, Barbé, Barbara¹, Spaepen, Marijke², Janssen, Hilde¹, Haustermans, Karin¹, Begg, Adrian³, Nuyts, Sandra¹, ¹ Department of Radiation Oncology, Leuven, Belgium, Belgium² Centre for Human Genetics, Leuven, Belgium, Belgium³ Experimental Therapy, Amsterdam, The Netherlands, The Netherlands
(PP297) The correlation between hypoxia and microsatellite alterations in head and neck squamous cell carcinoma.

DeMott, Michael^*,1, Karadedeli, Betul¹, Cosgrove, Joseph¹, Dedon, Peter¹, ¹ Biological Engineering Division, Cambridge, MA, USA
(PP298) Phosphorylation of yeast histone H2A as a biomarker for deoxyribose oxidation in DNA.

Kovalchuk, Olga^*,1, Koturbash, Igor ¹, Hendricks, Carrie², Stevenson, Sandie ¹, Engelward, Bevin^*,2, ¹ Department of Biological Sciences, Lethbridge, AB, Canada² Biological Engineering Division, Cambridge, MA, USA
(PP299) Role of homologous recombination in radiation-induced genome instability, adaptive response and bystander effect in vivo.

Epperly, Michael^*,1, Fink, Mitchell², Hricisak, Lauren¹, Zhang, Xichen¹, Greenberger, Joel¹, ¹ Radiation Oncology, Pittsburgh, PA, USA² Critical Care Medicine, Pittsburgh, PA, USA
(PP300) Incubation of 32D cl 3 factor-dependent hematopoietic cells in ethyl pyruvate (EP) increases radiation resistance.

Fan, Jinjiang^*,1, Shen, Zhiyuan¹, ¹ Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP301) Identification of BISET1, a BCCIP-Interacting SET domain protein.

Miller, Susan¹, Ferrarotto, Catherine^*,1, Vlahovich, Slavica², Wilkins, Ruth¹, Boreham, Douglas³, Dolling, Jo-Anna^{3, 4}, ¹ Consumer and Clinical Radiation Protection Bureau, Ottawa, ON, Canada² Radiation Protection Bureau, Ottawa, ON, Canada³ McMaster Institute of Applied Radiation Sciences, Hamilton, ON, Canada⁴ Genetics Department, Mississauga, ON, Canada
(PP302) Canadian Cytogenetic Emergency Network (CEN) for biological dosimetry following radiological/nuclear accidents.

George, Kerry^{*,1, 3}, Durante, Marco ², Cucinotta, Francis³, ¹ Wyle Laboratories, Houston, TX, USA³ NASA, Lyndon B. Johnson Space Center, Houston, TX, USA² University Federico II, Naples, Italy
(PP303) Chromosome aberrations in the progeny of human lymphocytes exposed to energetic heavy ions.

Gibbons, Catherine^{*,1, 2}, Natarajan, Mohan³, Mohan, Sumathy⁴, Pandeswara, S³, Moore, Stephen¹, Grosovsky, Andrew², Kadhim, Munira¹, ¹ Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK² Environmental Toxicology Graduate Program, Riverside, CA, USA³ Department of Radiation Oncology, San Antonio, TX, USA⁴ Department of Pathology, San Antonio, TX, USA
(PP304) TNF as a potential signaling mediator of genomic instability and the bystander effect.

Hagelstrom, R.^*,1, Chang, Sandy², Bailey, Susan¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, Colorado, United States² Department of Molecular Genetics, Houston, Texas, United States
(PP305) WRN-deficient cells exhibit unusually high rates of telomeric recombination.

Han, Jianxun^*,1, Hendzel, Michael^{1, 2}, Turner, Joan^{1, 2}, ¹ Department of Oncology, Edmonton, Alberta, Canada² Division of Experimental Oncology, Edmonton, Alberta, Canada
(PP306) Extensive and asynchronous H2AX phosphorylation after ionizing irradiation.

Hinz, John^*,1, Tebbs, Robert¹, Urbin, Salustra¹, Nham, Peter¹, Salazar, Edmund¹, Kopf, Vicki¹, Yamada, N.¹, Thompson, Larry¹, ¹ Biosciences Directorate, Livermore, CA, USA
(PP307) Role of Rad51 paralogs in genomic stability and resistance to DNA damage.

Holt, Stewart^*,1, Francisco, Dave¹, Hada, Megumi¹, Georgakilas, Alexandros¹, ¹ Biology Department, Greenville, NC, USA
(PP308) Detection of oxidative clustered DNA lesions in human cancerous cell lines.

Hopkins, Kevin^*,1, Balajee , Adayabalam¹, Lieberman, Howard¹, ¹ Center for Radiological Research, New York, NY
(PP309) Deletion of mouse Rad9 leads to high spontaneous frequencies of sister chromatid exchange.

Joiner, Michael^*,1, Krueger, Sarah¹, Wright, Jennifer¹, Piasentin, Ivano¹, Wilson, George¹, Marples, Brian¹, ¹ Department of Radiation Oncology, Detroit, MI, USA
(PP310) Inverse dose rate effects mediated by low-dose hyper-radiosensitivity in prostate cancer cell lines.

Kachnic, Lisa^*,1, Willers, Henning¹, Li, Li¹, Treszezamsky, Alejandro¹, Powell, Simon^{1, 2}, ¹ Department of Radiation Oncology, Boston, MA, USA² Department of Radiation Oncology, St. Louis, MO, USA
(PP311) Differential sensitivity of FancA- and FancD2-deficient cells to complex DNA double strand damage.

Park, Mi-Young¹, Seo, Min-Ji¹, Park, Hyun-Jin¹, Kwon, Hee-Kyung¹, Kim, Tae-Hwan², Lee, Su-Jae³, Lee, Yun-Sil⁴, Ji, Young-Hoon¹, Cho, Chul-Koo¹, Choi, Soo-Yong¹, Kang, Chang-Mo^*,1, ¹ Lab. of Radiation Cytogenetics and Epidemiology, Seoul, Seoul, Korea² Dept. of Veterinary Medicine, Taegu, Seoul, Korea³ Lab. of Radiation Experimental Therapeutics, Seoul, Seoul, Korea⁴ Lab. of Radiation Effect, Seoul, Seoul, Korea
(PP312) Correlation between conventional dicentric assay and micronuclei assay for biodosimetry in cultured peripheral blood lymphocytes of Korean individuals.

Kataoka, Yasushi^*,1, Murley, Jeffrey¹, Grdina, David¹, ¹ Radiation and Cellular Oncology, Chicago, IL, USA
(PP313) Aminothiols can reduce -H2AX formation against X-irradiation in human microvascular endothelial cells.

Kato, Takamitsu^*,1, Nagasawa, Hatsumi¹, Bedoford, Joel, ¹ Department of Environmental & Radiological Health Sciences, Ft. Collins, Colorado, USA
(PP314) Interstitial -H2AX foci in metaphase chromosomes after irradiation of wild-type and repair deficient G1 cells.

Kawata, Tetsuya^*,1, Shigematsu, Naoyuki², Uno, Takashi¹, Saito, Masayoshi¹, Kan'o, Momoe¹, Ito, Hisao¹, George, Kerry³, Cucinotta, Francis³, ¹ Department of Radiology, Chiba-shi, Chiba, Japan² Department of Radiology, Shinjukuku-ku, Tokyo, Japan³ Radiation Biophysics, Houston, TX, USA
(PP315) Caffeine sensitizes non-dividing human fibroblasts to X-rays or high-LET radiation by inducing high frequency of misrepair.

Kim, Grace^{*,1, 2}, Fiskum, Gary ⁴, Morgan, William^{1, 2, 3}, ¹ Radiation Oncology Research Laboratory, Department of Radiation Oncology, Baltimore, MD, USA² Molecular and Cell Biology Program, Baltimore, MD, USA⁴ Department of Anesthesiology, Baltimore, MD, USA³ Marlene and Stewart Greenbaum Center, Baltimore, MD, USA
(PP316) Mitochondrial dysfunction may perpetuate radiation induced genomic instability.

Koturbash, Igor¹, Pogribny, Igor², Stevenson, Sandie¹, Kovalchuk, Olga^*,1, ¹ Department of Biological Sciences, Lethbridge, AB, Canada² Division of Biochemical Toxicology, Jefferson, AR, USA
(PP317) Chronic low dose radiation exposure profoundly alters DNA and histone methylation in murine thymus.

Baker, Mike^*,1, Koturbash, Igor¹, Stevenson, Sandie ¹, Loree, Jonathan¹, Kovalchuk, Olga^*,1, ¹ Department of Biological Sciences, Lethbridge, AB, Canada
(PP318) Role of epigenetic mechanisms in radiation-induced transgenerational hematopoietic carcinogenesis.

Krueger, Sarah^*,1, Joiner, Michael¹, Piasentin, Evano¹, Wilson, George¹, Marples, Brian, ¹ Department of Radiation Biology, Detroit, MI, USA
(PP319) Differential G2 checkpoint responses to low-dose radiation.

Laiakis, Evagelia^{*,1, 2}, Morgan, William^{1, 3}, ¹ Radiation Oncology Research Laboratory/ Department of Radiation Oncology, Baltimore, Maryland, USA² Graduate Program in Human Genetics, Baltimore, Maryland, USA³ Greenebaum Cancer Center, Baltimore, Maryland, USA
(PP320) A role for bystander-like factors in maintaining genomic instability.

Shuryak, Igor¹, Lange, Christopher^*,1, ¹ Radiation Oncology/Radiobiology, Brooklyn, NY, USA
(PP321) Cell survival model with DSB repair time regulated by a dose-dependent repair-inhibitory signal.

Lee, Kyung-Jong ^*,1, Yajima, Hirohiko¹, Qin, Jun², Chen, Benjamin¹, Chen, David¹, ¹ Division of Molecular Radiation Biology, Department of Radiation Oncology, Dallas, TX, USA² Department of Molecular and Cellular Biology, Houston, TX, USA
(PP322) Implication of interaction between catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and BRCA1.

Leloup, Corinne^*,1, Zhu, Aiping¹, Hopkins, Kevin¹, Lieberman, Howard¹, ¹ Center for Radiation research, New York, NY, USA
(PP323) Mrad9B^-/- ES cells are sensitive to DNA damaging agents.

Lemon, Jennifer^*,1, Rollo, C. David², Boreham, Douglas¹, ¹ Medical Physics and Applied Radiaions Sciences, Hamilton, ON, Canada² Biology, Hamilton, ON, Canada
(PP324) A complex dietary supplement dramatically reduces radiation-induced chromosome aberrations and H2AX foci in mice expressing elevated free radical processes.

Balajee, Adayabalam¹, Hopkins, Kevin¹, Lieberman, Howard^*,1, ¹ Center for Radiological Research, New York, NY, USA
(PP325) Role of Rad9 in base excision repair.

Krempler, Andrea¹, Deckbar, Dorothee¹, Tchouandong, Leopoldine¹, Walker, Sarah², Jeggo, Penny², Lobrich, Markus¹, ¹ Biophysics Department, Homburg, Saar, Germany² Genome Damage and Stability Centre, East Sussex, BN, UK
(PP326) ATM-dependent double-strand break repair and checkpoint functions co-operate to maintain chromosomal stability after ionizing irradiation.

Lu, Huimei^*,, Shen, Zhiyuan¹, ¹ Dept. of Molecular Genetics and Microbiology, MSC08-4660, Albuquerque, NM, USA
(PP327) Regulation of homologous recombination by BCCIP.

Malone, Jennifer^*,, Lieberman, Rita, Holt, Jeff,
(PP328) The role of BRCA2 in Rad51 localization during breast carcinogenesis.

Wykes, Susan¹, Wilson, George¹, Joiner, Michael¹, Piasentin, Evano¹, Wright, Jennifer¹, Marples, Brian^*,1, ¹ Department of Radiation Oncology, Detroit, Michigan, USA
(PP329) Low-dose hyper-radiosensitivity does not result from a failure to recognize DNA double-strand breaks.

Masanori, Someya^*,1, Sakata, Koh-ich¹, Matsumoto, Yoshihisa², Yamamoto, Hiroyuki³, Monobe, Manami⁴, Ikeda, Hideyuki⁵, Ando, Kouichi⁶, Hosoi, Yoshio², Suzuki, Norio², Hareyama, Masato¹, ¹ Sapporo Medical University, Sapporo, Japan² University of Tokyo, Tokyo, Japan³ Sapporo Medical University, Sapporo, Japan⁴ Tokyo University of Science, Noda, Chiba, Japan⁵ Sapporo Medical University, Sapporo, Japan⁶ National Institute of Radiological Sciences, Chiba, Japan
(PP330) The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.

McCann, Kelly^*,1, Spikacova, Tatiana^*,1, Game, John², Brown, J. Martin¹, ¹ Department of Radiation Oncology, Stanford, CA, USA² Life Sciences Division, Berkeley, CA, USA
(PP331) DNA repair response requires chromatin remodeling through histone modification.

Qutob, Sami¹, Chauhan, Vinita¹, Bellier, Pascale¹, Gajda, Greg¹, Thansandote, Art¹, Yauk, Carole¹, Douglas, George¹, McNamee, James^*,1, ¹ Healthy Environments and Consumer Safety Branch, Ottawa, Ontario, Canada
(PP332) Gene expression profiling of a human glioblastoma cell line exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.

McNiel, Elizabeth^*,1, Madrill, Nicole¹, Griffin, Kelly¹, Mickelson, James², ¹ Department of Veterinary Clinical Sciences, Saint Paul, MN, USA² Department of Veterinary and Biomedical Sciences, Saint Paul, MN, USA
(PP333) Dogs at high risk for transitional cell carcinoma exhibit microsatellite instability in tumors.

Medvedeva, Natalia^*,1, Panyutin, Igor¹, Neumann, Ronald¹, ¹ Clinical Center, Department of Nuclear Medicine, Bethesda, MD, USA
(PP334) Phosphorylation of histone H2AX in radiation-induced micronuclei.

Meng, Xiangbing^*,1, Shen, Zhiyuan¹, ¹ Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP335) Knockdown of BCCIP impairs p53-transactivation activity in response to irradiation.

Moore, Stephen^*,1, Folkard, Melvyn², Prise, Kevin², Kadhim, Munira¹, ¹ Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom² Gray Cancer Institute, Northwood, Middlesex, United Kingdom
(PP336) Interindividual variation in genomic instability after targeted charged particle microbeam irradiation.

Morris, Dale^*,1, Mitchel, Ron², Knox, David³, Lavoie, Josée¹, Lemon, Jennifer¹, Ramdoo, Brendon¹, Parchaliuk, Debra³, Boreham, Doug¹, ¹ Medical Physics, Hamilton, Ontario, Canada² Chalk River Branch of the Canadian Nuclear Society, Deep River, Ontario, Canada³ Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada
(PP337) Examination of gene expression in trp53 heterozygous mice exposed to low dose radiation using oligo nucleotide cDNA microarrays.

Moskalenko, Oleksandr^*,1, Grygoryev, Dmytro¹, Zimbrick, John¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, USA
(PP338) Changes in transcription of selected DNA repair genes induced by exposure of medaka cells to Cd and ionizing radiation.

Mukherjee, Bipasha^*,1, Chen, Benjamin¹, Kobayashi, Junya², Chatterjee, Aloke ³, Chen, David¹, Burma, Sandeep¹, ¹ Dept. of Radiation Oncology, Dallas, TX² Department of Radiation Biology, Hiroshima, N/A, Japan³ Life Sciences Division, Berkeley, CA
(PP339) DNA-PK phosphorylates hstone H2AX during staurosporine-induced apoptosis of rodent cells.

Murray, David^*,1, Mirzayans, Razmik¹, ¹ Oncology/Experimental Oncology, edmonton, alberta, canada
(PP340) Involvement of ATM and p53 in the rejoining of DNA double-strand breaks at early times after exposure to ionizing radiation.

Nagasawa, Hatsumi^*,1, Peng, Yuanlin¹, Wilson, Paul¹, Lio, Yi-Ching², Chen, David², Bedford, Joel¹, Little, John³, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, United States² Department of Radiation Oncology, Dallas, TX, United States³ Center for Radiation Sciences and Environmental Health, Boston, MA, United States
(PP341) Role of homologous recombination in the alpha particle bystander effect for sister chromatid exchanges and chromosomal aberrations.

Nishioka, Takeshi^*,1, Yasuda, Motoaki², Shirato, Hiroki³, ¹ Hokkaido University, Sapporo, Japan² Hokkaido University, Sapporo, Japan³ Hokkaido University, Sapporo, Japan
(PP342) Molecular mechanism behind 'repopulation': A gene expression profiling and pathological in-vitro/in-vivo study of a transplantable mouse tumor cell line.

Noguchi, Miho^{*,1, 2, 3}, Okada, Maki³, Okabe, Atushi³, Ando, Koichi², Okayasu, Ryuichi³, ¹ Graduate School of Science and Technology, Chiba-shi, Chiba-ken, Japan² Heavy-Ion Radiobiology Research Group, Chiba-shi, Chiba-ken, Japan³ International Space Radiation Laboratory, Chiba-shi, Chiba-ken, Japan
(PP343) Comparison of DNA double strand break repair between irradiated normal human lymphocytes and normal human fibroblasts.

Lehnert, Shirley ¹, Sadekova, Svetlana¹, Park, Morag¹, Hudson, Thomas², Novak, Jaroslav², ¹ Oncology, Montreal, Quebec, Canada² Montreal Genome Centre, Montreal, Quebec, Canada
(PP344) Genetic analysis of a human ovarian cell line resistant to cis platinum and ionizing radiation.

Byrne, Shaun¹, Bellon, Sophie¹, Lomax, Martine¹, O'Neill, Peter^*,1, ¹ DNA Damage Group, Harwell, Oxon, UK
(PP345) Clustered damage: 5,6-dihydrothymine retards base excision repair of an AP site by xrs5 nuclear extracts.

Ohnishi, Takeo^*,1, Takahashi, Akihisa¹, ¹ Dept. Biol., Kashihara, Nara, Japan
(PP346) The DSB-recognizing proteins phospho-Nbs1 and Mre11 co-localize with H2AX in the cell nucleus after heat treatment as well as X-ray irradiation.

Parsons, Jason^*,1, Dianov, Grigory¹, ¹ Radiation and Genome Stability Unit, Didcot, Oxfordshire, UK
(PP347) Processing of 8-oxoguanine within close proximity to a DNA single strand break.

Paunesku, Tatjana^*,1, Flores, Ludmila², Protic, Miroslava³, Cruz, Cecille¹, Petrikas, James⁴, Shivnani, Anand⁴, Babbo, Angela¹, Hlatky, Lynn², Woloschak, Gayle¹, ¹ Department of Radiology, Feinberg School of Medicine, Chicago, IL, USA² Deptartment of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA, USA³ Biology Division, Argonne, IL, USA⁴ Division of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA
(PP348) In vivo and in vitro activity of mutant PCNA promoter from radiation sensitive wasted mice.

Perkins, Michael^*,1, Kumar, K. Sree¹, ¹ Radiation Casualty Management Team, Bethesda, MD, US
(PP349) In vitro protection against ionizing radiation by the novel radioprotectant ON01210.

Petrikas, James^*,1, Shivnani, Anand¹, Cruz, Cecille², Babbo, Angela², Paunesku, Tatjana², Woloschak, Gayle², ¹ Northwestern University, Chicago, IL, United States² Northwestern University, Chicago, IL, United States
(PP350) Differential response to irradiation of wild-type proliferating cell nuclear antigen (PCNA) promoter and mutant PCNA promoter from radiation sensitive wasted (wst) mice.

Pogozelski, Wendy^*,1, Hill, Helene², Blakely, William³, Patel, Janhvi¹, Arpaia, Nicholas¹, Rummel, Svend¹, Senfield, Jeffrey¹, Bernard, Matthew¹, O'Donnell, Robert⁴, ¹ Department of Chemistry, Geneseo, NY, USA² Department of Radiology, Newark, NJ, USA³ Department of Applied Cellular Radiobiology, Bethesda, MD, USA⁴ Department of Biology, Geneseo, NY, USA
(PP351) Radiation-induced increase in the 4977-bp "common deletion" in human mitochondrial DNA in lymphoblast and fibroblast cells.

Sun, Lijie¹, Mauldin, Stanley ², Wallon, Margaretha¹, Oliver, Anthony¹, DiRienzo, Sharon¹, Stamato, Thomas^*,1, ¹ Lankenau Institute for Medical Research, Wynnewood, PA, USA² Department of Biology, Philadelphia, PA, USA
(PP352) Purification of a DNA end binding complex with a non-Ku-like mobility shift pattern.

Sudo, Hiroko^*,1, Stampfer, Martha¹, Barcellos-Hoff, Mary-Helen^*,1, Kronenberg, Amy¹, ¹ Life Science, Berkeley, CA, United States
(PP353) Persistent genomic instability induced by HZE particle radiation in human mammary epithelial cells.

Muto, Masahiro¹, Kubo, Eiko ¹, Fujimori, Akira¹, Nenoi, Mitsuru¹, Daino, Kazuhiro¹, Matsuda, Yoichi², Kuroiwa, Asato², Ukai, Hideki¹, Tsuji, HIdeo¹, Tatsumi, Kouichi^*,1,3, ¹ Research Center for Radiation Safety, Chiba, Chiba, JAPAN² Laboratory of Cytogenetics and Division of Bioscience, Sapporo, Hokkaido, JAPAN³ Institute of Radiation Epidemiology, Tokyo, JAPAN
(PP354) Isolation of human radiation susceptibility gene, hNp95.

Thompson, Larry^*,1, Hinz, John¹, Salazar, Edmund ¹, ¹ Biosciences Directorate, Livermore, CA
(PP355) The FANCG Fanconi anemia cancer suppressor protein helps minimize spontaneous and radiation-induced chromosomal rearrangements.

Tinnel, Brent^*,1, McGarry, Ronald¹, Mendonca, Marc³, Cummings, Oscar², Chin-Sinex, Helen³, Timmerman, Robert⁴, ¹ Indiana University School of Medicine, Indianapolis, IN, United States³ Indiana University School of Medicine, Indianapolis, IN, United States² Indiana University School of Medicine, Indianapolis, IN, United States⁴ UT Southwestern Medical School, Dallas, TX, United States
(PP356) Pulmonary hilar radioablation: An animal model of radiotoxicity.

Turner, Emily^*,1, Dovichi, Norman¹, ¹ Department of Chemistry, Seattle, WA, USA
(PP357) Ultrasensitive analysis of protein expression in single Deinococcus radiodurans tetrads.

Uematsu, Naoya^*,1, Yajima, Hirohiko^*,1, Chen, Benjamin¹, Chen, David¹, ¹ Division of Molecular Radiation Biology, Department of Dadiation Oncology, Dallas, TX, US
(PP358) Live cell imaging of DNA-PK activation and localization at DSB sites induced by microbeam-laser irradiation.

Wang, Ya^*,1, Hu, Baocheng^{1, 2}, Liu, Shuang², Wang, Xiang¹, Rowe, Peter ³, Huang, Cuifen ², ¹ Radiation Oncology, Philadelphia, PA, USA² Molecular Biology, Beijing, China, China³ Periodontics, San Antonio, TX, USA
(PP359) A new role of MEPE/OF45 as a co-factor of CHK1 in DNA damage response.

Wang, Xiang^*,1, Wang, Ya¹, ¹ Dept. Radiation Oncology, Philadelphia, PA, USA
(PP360) Hus1 protecting mammalian cells from ionizing radiation induced killing is not through affecting non-homologous end-joining.

Wang, Hongyan^*,1, Wang, Xiang¹, Wang, Ya¹, ¹ Radiation Oncology, Philadelphia, PA, USA
(PP361) High-energy particles inhibit non-homologous end-joining but do not inhibit homologous recombination repair.

Lu, Hua-Rui¹, Wang, Ya¹, ¹ Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, philadelphia, PA, USA
(PP362) CHK1 interacts with PARP1 to respond to ionizing radiation-induced DNA damage.

Karimi-Busheri, Feridoun¹, Rasouli-Nia, Aghdass¹, Allalunis-Turner, Joan¹, Weinfeld, Michael^*,1, ¹ Experimental Oncology, Edmonton, Alberta, Canada
(PP363) Cellular evidence supporting human polynucleotide kinase involvement in the non-homologous end joining DNA repair pathway.

Williams, Eli^*,1, Bailey, Susan¹, Jeggo, Penelope², Ullrich, Robert¹, ¹ Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA² Genome Damage and Stability Centre, Falmer, Brighton, UK
(PP364) Characterization of DNA-PKcs telomeric end-capping function in mammalian cells.

Wilson, Paul^*,1, Nagasawa, Hatsumi¹, Warner, Christy¹, Little, John², Bedford, Joel¹, ¹ Environmental and Radiological Health Sciences, Fort Collins, CO, United States² Center for Radiation Sciences and Environmental Health, Boston, MA, United States
(PP365) Hypersensitivity of cultured fibroblasts from retinoblastoma family members and apparently normal controls: colony formation during continuous low-dose rate irradiation and G2 chromosomal radiosensitivity.

Liu, Jingmei¹, Wray, Justin^*,1, Shen, Zhiyuan, ¹ Dept. of Molecular Genetics and Microbiology, Albuquerque, NM, USA
(PP366) Sumoylation of human Rad52 is critical in its protein stability.

Yajima, Hirohiko^*,1, Wang, Junhua¹, Chen, David¹, Chen, Benjamin¹, ¹ Division of Molecular Radiation Biology, Department of Radiation Oncology, Dallas, TX, USA
(PP367) Involvement of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in UV damage response.

Yasui, Linda^*,1, Chen, Kai², Jones, T. Patrick¹, Caldwell, James¹, Guse, Diana¹, Kassis, Amin², ¹ Department of Biological Sciences, DeKalb, IL, USA² Department of Radiology, Boston, MA, USA
(PP368) Using Hoechst 33342 to target radioactivity to the cell nucleus.

Yu, Ying^*,1, Banath, Judit¹, MacPhail, Susan¹, Olive, Peggy ¹, ¹ Medical Biophysics Dept., Vancouver, BC, Canada
(PP369) Background expression of phosphorylated histone H2AX in tumor cells in relation to DNA double strand breaks and karyotypic complexity.

Zhang, Ying^*,1, Lim, Chang¹, Williams, Eli¹, Zhou, Junqing¹, Zhang, Qinming¹, Fox, Michael¹, Bailey, Susan ¹, Liber, Howard¹, ¹ Department of Environmental and Radiological Science, Ft. Collins, CO, USA
(PP370) NBS1 knockdown increases telomere association and radiation mutagenesis in human cells.

Zhou, Junqing ^*,1, Zhang, Ying ¹, Zhang, Qinming ¹, Lim , Chaung ¹, Liber, Howard¹, ¹ Department of Enviromental and Radiological Health Sciences, Fort Collins, CO, USA
(PP371) Rad54 knockdown enhances radiation-induced cell killing and mutation in human cells.

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2005 RRS