PARENT SESSION
PT2 - Endocrine Disruption
Tuesday, 19 November 2002
8:00 AM to 6:30 PM
Exhibit Hall
(P552) Detailed Review Paper for fish multi-generation and partial life-cycle reproductive and developmental toxicity tests.
Skillman, Ann*,1, Schultz, Irvin1, Nagler, James2, Dionne, Emily3, Blanton, Michael1, 1 Battelle Pacific Northwest National Laboratory, Sequim, WA, USA2 University of Idaho, Moscow, Idaho, USA3 Springborn Labs, Wareham, Massachusetts, USA
ABSTRACT- We are developing a Detailed Review Paper (DRP) for a fish multi-generation and partial life-cycle reproductive and developmental toxicity test with endocrine endpoints for the U.S. Environmental Protection Agency. The fish multi-generation and partial life-cycle DRP will summarize, explain, and document relevant principles, methods, and techniques recommended for development of an initial protocol(s), and will identify those issues that may require prevalidation studies to adequately address. The focus of the DRP will be on a multi-generation reproductive/developmental toxicity test and a partial life-cycle reproductive/developmental toxicity test for endocrine effects in four species of fish (i.e., fathead minnow, zebrafish, Japanese medaka, and sheepshead minnow). The DRP will provide a basis for selecting the most promising methods for assessing chemical effects on fish endocrine systems and for determining future studies required to resolve outstanding issues relative to method development, including the need for additional targeted prevalidation studies. This information will be used to support the design of a draft protocol for use in the validation phase of protocol design, with the ultimate goal of developing future EPA/OECD test method guidelines. The preliminary findings from initial DRP efforts will be presented.
Key words: endocrine disruption, detailed review paper, fish multi-generation reproductive test