PARENT SESSION
PS12 - Applications of LC-MS in Environmental Analysis
Sunday, 17 November 2002
8:00 AM to 6:30 PM
Exhibit Hall
(P130) Analysis of Perchlorate in Drinking Water and Human Serum by LC-MS/MS.
Flaherty, John*,1, Risha, Karen1, Decker, Emily1, Spare, William1, 1 Exygen Research, State College, PA, USA
ABSTRACT- The purpose of this study was to develop an LC-MS/MS method capable of detecting perchlorate (ClO4-) at ng/mL (ppt) concentrations in water and at ng/mL (ppb) concentrations in human serum. The data show that we can achieve a method detection limit (MDL) of ~ 15-20 ppt in reagent-grade water. We have established accuracy and precision at fortifications ranging from 100 ppt to 2500 ppt in ground water, bottled water, surface water, tap water, and Type I water. We have also developed a method for the detection of perchlorate in human serum. The limit of quantitation (LOQ) for this analysis, based on the lowest fortification, was 5 ppb.
Key words: Perchlorate, LC-MS/MS, Toxicology, Ion Chromatography