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(P594) Environmental Fate and Effects of the Aquaculture Therapeutant Potassium Permanganate.
Hobbs, Melissa*,1,2, Grippo, Richard1, Farris, Jerry1, Griffin, Billy2, Harding, Lora1, 1 Arkansas State University, State University, Arkansas, USA2 H.K. Dupree SNARC/ARS/USDA, Stuttgart, Arkansas, USA
ABSTRACT- Potassium permanganate (KMn04) is a freshwater aquaculture drug widely used for the treatment and prevention of waterborne parasitic and fungal diseases. However, it is not yet approved by the U.S. Food and Drug Administration (USFDA) for use as a therapeutant. The requirements for USFDA approval of a new therapeutant include demonstration of efficacy, residue chemistry, target animal safety and an environmental/ecological risk assessment. The USFDA's Center of Veterinary Medicine, responsible for approving new animal drugs, has requested more information concerning KMn04's environmental safety. The goal of this research is to generate fate and effects data suitable for use in developing an ecological risk assessment (ERA) of potassium permanganate. The information in this ERA will be used by the USFDA for evaluating whether this chemical should be approved for use in food fish. To achieve this goal, the following objectives will be met: 1) determine the acute sediment and water column toxicity of KMn04 in controlled laboratory conditions; 2) determine chronic toxicity in controlled laboratory conditions; 3) evaluate fate and toxicity in pond water under recommended dose and worst-case overdose scenarios and 4)determine the fate and toxicity of this chemical in simulated warm-water pond (mesocosm) conditions. To date, acute toxicity test results using treated moderately hard synthetic test water show static 96hr LC50 values of 0.039 + 0.009 mg/L (Daphnia magna), 0.052 + 0.010 mg/L (Ceriodaphia dubia) and 1.88 + 0.29 mg/L (Pimephales promelas). These values are below the generally recommended KMn04 disease treatment. Tests in progress will reveal what ameliorating effect pond water or mesocosm water may have on KMn04 toxicity.
Key words: metals, toxicity, ERA, aquaculture
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