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PH07 Making Ecotoxicology Studies Relevant
(PH071) Integrating Dose-Response With Species Sensitivity Distributions.
Giddings, J1, Gonzalez-Valero, J2, Warren-Hicks, W3, 1 The Cadmus Group, Inc., Rochester, MA, USA2 Syngenta Crop Protection, Greensboro, NC, USA3 The Cadmus Group, Inc., Chapel Hill, NC, USA
ABSTRACT- In conventional analysis of a species sensitivity distribution (SSD), species are ranked based on toxicity point estimates such as the EC50 or No Observed Effect Concentration. This approach does not incorporate information on the variability of sensitivity within species, as reflected in dose-response curves. We explored techniques for integrating dose-response information with SSDs using growth inhibition data for 37 species of aquatic plants with atrazine. Log-probit dose-response relationships were estimated for each species and used to generate three types of effects analyses: (1) conventional SSDs based on different point estimates (ECx values); (2) conventional dose-response relationships for species representing different percentiles of sensitivity distribution; and (3) a combined 3-dimensional model depicting the distribution of species-specific growth inhibition percentages over a range of exposure concentrations. The 3-dimensional analysis shows the relationship between the fraction of species affected and the magnitude of effect (% growth inhibition) at different concentrations, which is useful in deriving ecological effects benchmarks for chemicals in aquatic systems.
Key words: dose-response, species sensitivity distribution, aquatic plants, atrazine
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