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HA9 Endocrine Disruption in Aquatic Environments
(557) Progress in the OECD work on Endocrine Disrupters Testing and Assessment for environmental species.
Gourmelon, A1, Hutchinson, TH2, Ankley, GT3, 1 Organisation For Economic Co-operaiton and Development, Paris, France2 AstraZeneca- Brixham Environmental Laboratory, Devon, United Kingdom3 EPA Mid-Continent Ecology Division, Duluth, United States
ABSTRACT- The OECD Special Activity on endocrine disrupters testing and assessment (EDTA) started in 1996 at the request of member countries and industry with the objective to develop test methods for the detection and characterization of endocrine disrupting chemicals. The purpose of the EDTA Task Force is to ensure harmonization of testing strategies for screening and testing. Practical tools are also being developed to facilitate sharing of testing results and assessment. Importantly, the EDTA Task Force oversees validation work for newly developed and enhanced test methods, through Validation Management Groups (VMGs): i) mammalian toxicological tests, ii) ecotoxicological tests, and, iii) non-animal tests. Validation is necessary to establish the relevance and reliability of the test and allow its regulatory acceptance. A conceptual framework captures potential screening and testing needs in both human health and ecotoxicological areas. The framework attempts to identify tests at different levels of biological and regulatory complexity, including interactions with hormone receptors, tests in vivo at sensitive life stages and tests assessing transgenerational effects. The VMG for ecotoxicity tests oversees the development and validation of test methods for fish, birds, amphibians and invertebrates. Initial validation of a fish non-spawning screening assay for the detection of endocrine disrupters is underway. The assay comprises three core endpoints: vitellogenin measurement, gross morphology (including GSI) and gonad histopathology, expected to be sensitive for the detection of chemicals acting as (anti) estrogen, (anti) androgen and aromatase inhibitors. Longer term testing methods in fish are also considered. A frog metamorphosis assay is being developed for thyroid disruption. Avian reproduction tests are under discussion as well as invertebrate life-cycle tests.
Key words: screening, endocrine disruption, testing, regulatory framework
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