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() Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon Acipenser transmontanus.
TenBrook, P.1, Kendall, S.1, Tjeerdema, R.1, 1 University of California, Davis, Davis, CA, 95616
ABSTRACT- White sturgeon Acipencer transmontanus were exposed to 7.2 mM (1.0 ppm) 14C-labelled p-nitrophenol (PNP) for 24 h, then were allowed to depurate in clean seawater for another 24 h. Absorption, conditional uptake clearance and elimination rate constants were 0.11 + 0.03 h-1, 11.1 + 3.0 mL g-1 h-1 and 4.9 x 10-3 + 1.5 x 10-3 h-1, respectively. A whole-organism total concentration factor (TCF) of 21.9 + 3.2 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 85.7% of absorbed PNP within 24 h, of which 53.0 + 8.3% was unmetabolized parent compound, 39.1 + 8.3% was p-nitrophenylsulfate and 9.6 + 3.6% was p-nitrophenyl-
-D-glucuronide.
Key words: Acipencer transmontanus, p-nitrophenol, toxicokinetics, biotransformation