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PT14 Toxicity of Mixtures
(PT230) Body burdens and mixture toxicity assessment of anionic surfactants to the fathead minnow (Pimephales promelas).
Rawlings, J1, Belanger, S1, Price, B1, Smith, C1, Versteeg, D1, 1 The Procter & Gamble Company, Cincinnati, OH, USA
ABSTRACT- We investigated the utility of water column and tissue-based exposure metrics to understand single chemical and mixture toxicity of surfactants. Pimephales promelas was used in acute and chronic tests with the anionic surfactants sodium dodecylbenzene sulfonate (LAS), sodium dodecyl sulfate (AS) and tetradecyl diethylene sulfate (AES) singularly and in a mixture. The acute mixture exposure at equitoxic concentrations of LAS, AS and AES resulted in LC50 and LBB50 values of 0.039 mmol/L and 0.17 mmol/kg. EC20 and EBB20 values in the chronic mixture study were 0.012 mmol/L and 0.082 mmol/kg. Both acute and chronic mixture data compared well with single compound data. The laboratory studies conform to concentration addition models for water column and tissue-based exposures. It is likely that tissue-based assessments will prove most predictive for environmental risk assessments because biotransformation and bioavailability are properly considered; however, field validation is needed to confirm this concept.
Key words: mixture toxicity, body burdens, anionic surfactants, fathead minnow
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