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WA2 Chemical and Biological Analysis of Endocrine Disrupting Compounds
() Estrogen and androgen receptor agonists: Identification and measurement of in vitro activity in the aquatic environment.
Thomas, K1, Balaam, J1, Hurst, M1, Thain, J1, 1 CEFAS, Burnham on Crouch, Essex, CM0 8HA
ABSTRACT- Effects consistent with exposure to estrogenic and androgenic substances have been observed in wild fish populations. In the UK, this has been predominantly observed as the occurrence of elevated plasma vitellogenin (VTG) concentrations in certain freshwater and estuarine species (e.g. flounder). In order to assess the risk that estrogenic and androgenic substances pose to the aquatic environment, and to regulate activities that may be releasing such compounds, there is a need to identify which compounds are responsible for these effects. It is possible to identify the compounds responsible for in vitro effects by using a combination of in vitro receptor based assays and chemical analysis. For example, steroid estrogens have been identified as responsible for the majority of the activity seen in marine sewage treatment works (STW) effluents. Targeted chemical analysis and bioanalytical monitoring can then be applied to assess the effectiveness of additional treatment processes in reducing the estrogenic activity of STW effluents. This and other applied examples are used to show how estrogenic and androgenic substances can be identified in the environment, how bio- and chemical analysis can be used to assess their effects in the environment and how the information obtained can be used in both regulatory and policy frameworks.
Key words: bioassay-directed analysis, Monitoring, Endocrine disrupters
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