PM07 Pollutant Chemistry Transport, Cycling and Fate
Exhibit Hall
8:00 AM - Monday
(PM093) Concept of xenobiotic metabolism at the ecosystem level: application to hydroxypyrene in cold marine waters.
Saint-Louis, R1, Pelletier, E1, 1 Institut des Sciences de la Mer de Rimouski, Rimouski, Quebec, Canada
ABSTRACT- The objective of this work was to determine the kinetic metabolism of 1-hydroxypyrene in cold water by the blue mussel Mytilus edulis. The production of metabolites was monitored by HPLC-ESI-MS in the seawater during the course of exposure in 1 litre tanks. Our results demonstrated that this species is able to accumulate, transform and excrete 90% of hydroxypyrene at high dose in 48 hours, under cold conditions. The present study shows that M. edulis phase II metabolism responds rapidly to phase I metabolite exposure and sulphate conjugation largely predominates over glucuronidation or glucosidation. We propose a concept of phase I and phase II metabolism of organic pollutants at the ecosystem level based on the central hypothesis that some species or class of species are more efficient at phase I metabolites production while others have a better capacity to process further the biotransformation to phase II metabolites by conjugation of phase I metabolites after their uptake. In the frame of the propose concept the notion of key species will not only encompass ecological relations but also ecotoxicological functions. Accordingly, M. edulis would be an efficient phase II species.
Key words: metabolism, hydroxypyrene, ecosystem, mytilus edulis