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IP01 Ecotoxicity of Pharmaceuticals
(IP008) Phototoxicity screening employing two aquatic organisms.
Vytlacilova, J.1, Chobot, V.1, Jahodar, L.1, 1 Charles University, Faculty of Pharmacy, Hradec Kralove, Czech Republic
ABSTRACT- Phototoxicity is defined as a toxic response that is elicited after the first exposure of the organism to certain chemicals and subsequent exposure to UV radiation or visible light. This reaction depends on the dose of the radiation and the concentration of the photosensitizer in the organism. The structures of the photosensitizers are relatively different. Nevertheless, an aromatic system and/or conjugated multiple bonds are present in their molecules. Since the substances can occur in plants, food, cosmetics and various pharmaceutical preparations they may penetrate to environment and then be incorporated in the trophic chain. The aim of this pilot study is to assess the effect of four different photodynamically active substances used in pharmacy and UVA radiation on the generally used organism in ecotoxicology Artemia salina L. and alternatively employed species Tubifex tubifex Mull. The activity of the phototoxins and the sensitivity of both organism were evaluated by the comparison of the values of standard ecotoxicological parameters LOAEC, NOAEC, EC50. Patho-morphological changes of the body surface were studied by scan microscopy (SEM). Results show different effects of the tested substances and also different sensitivity of the organisms to the activity of the phototoxins.
Key words: Tubifex tubifex , Phototoxicity, Artemia salina
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