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PH05 Fate and Effects of Energetic Compounds
(PH026) Reproductive effects of TNX in laboratory deer mice.
Smith, J1, Pan, X1, Gentles, A1, Smith, E1, Stormberg, A2, Cobb, G1, 1 Texas Tech University, Lubbock, TX, USA2 INEEL, Idaho Falls, ID, USA
ABSTRACT- To assess reproductive toxicity of the Royal Demolition Explosive (RDX) anaerobic metabolite TNX (hexahydro-1,3,5-trinitroso-1,3,5-triazine) in deer mice (Peromyscus maniculatus), breeding pairs of laboratory deer mice were exposed to TNX ad libitum via drinking water. TNX was administered at four doses-100 g/L, 10 g/L, 1 g/L, and control (0 g/L). Paired mice bred and produced pups. Pups were exposed from conception until sacrifice at postnatal day (PND) 45. Effects of exposure to TNX were investigated with the following endpoints: reproductive success, pup survival, pup weight gain, and organ weights. Initial findings indicate there were no significant differences in organ weights and growth curves (PND 21-PND 45). Chi square analysis indicates a non-independent relationship between dose group and mortality in the growth phase birth to PND 4. In addition, the effects on cytochrome P450 activity, gene expression, and microsatellite mutation rate will be examined from the acquired tissues.
Key words: deer mouse, TNX, Peromyscus maniculatus
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