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PH06 Agrochemicals, Pesticides, Pharmaceuticals
(PH059) A study on the degradability of the antimicrobial growth promoter flavomycin in chicken litter.
Eichhorn, Peter1, Aga, Diana1, 1 State University of New York at Buffalo, Buffalo, NY, USA
ABSTRACT- The antimicrobial compound flavomycin, also known as flavophospholipol, bambermycin or moenomycin, is a phosphorous-containing glycolipid produced by Streptomyces, species and is mainly active against gram-positive bacteria. It is approved in U.S. agriculture for growth-promoting purposes in chicken, turkey and swine farming. Continuous feeding at concentrations between 1 and 20 mg/kg increases the rate of weight gain and improves feed efficiency. Flavomycin is not absorbed in the treated animal to any great extent after oral administration, but relatively fast excreted via feces as intact molecule. In view of the more than 8 million metric tons of chicken litter produced annually in the U.S. and the frequent disposal of the animal waste on agricultural land as fertilizer, the goal of this work was to examine degradation profiles of flavomycin in chicken litter and to identify residual concentrations in contaminated litter. To this end, chicken litter was spiked with 20 mg/kg of flavomycin and the decline in concentration was monitored over a period of 30 days. Sterilized samples were used as control to account for abiotic elimination processes. Sample preparation comprised accelerated solvent extraction with methanol followed by clean-up on solid-phase extraction cartridges. Liquid chromatography-ion trap-mass spectrometry was applied for quantitative analysis of the antimicrobial.
Key words: degradation, antibiotics, mass spectrometry
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