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(PM255) The Delayed-Type Hypersensitivity Response is a Biomaker for Trichloroethylene Exposure.
Keil, D1, Hessmann, L2, Miller, J2, Eudaly, J3, Gilkeson, G2, Peden-Adams, M3, 1 NIOSH, Morgantown, WV, USA2 Dept. of Rheumatology, Medical University of South Carolina (MUSC), Charleston, SC, USA3 Dept. of Pediatrics and the Marine Biomedicine and Environmental Science Center, MUSC, Charleston, SC, USA
ABSTRACT- Trichloroethylene (TCE) is an industrial solvent used in the cleaning and degreasing of metal components in various machine industries. Not only is it commonly inhaled during occupational situations, but its widespread use has resulted in groundwater contamination leading to human exposure via drinking water. It has been reported, in murine studies, that TCE can both exacerbate autoimmune disease and suppress immune function. While these studies have addressed immunological effects in adult rodent models, none have explored immunological effects during developmental stages. Exposure to TCE in drinking water (1000 ppb or 10,000 ppb) began when pairs were mated (female C57 and male C3H mice) and continued through weaning to adulthood (56-days old). The vehicle control group was administered Emulphor-treated water. Immune paramters measured in this study included delayed-type hypersensitivity, host resistance to B16F10 tumor challenge and auto-antibody production. At 56-days of age, a dose responsive increase in delayed-type hypersensitivity was observed in both male and female offspring. No inrease in succeptibility to tumor challenge was noted and no increases in autoantibody production was observed. This study demonstrates that in a murine model lifetime exposure to TCE causes increased hypersensitivity responses indicating immunity and can altered cell-mediated immunity.
Key words: delayed type hypersensitivity, TCE, groundwater contamination, immune function
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