PW09 Pesticide I
8:00 AM - Wednesday
(PW154) Determination of Azinophosmethyl Metabolites on Apples from Hood River, Oregon.
Birdsong, N.1, 2, Anderson, K.1, 2, Jenkins, J.1, 1 Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA2 Food Safety and Environmental Stewardship Program, Corvallis, OR, USA
ABSTRACT- In the past forty years concern over the effect of long-term exposure to pesticides has increased. Organophosphate pesticides (OP) account for almost fifty percent of the insecticides used in the US. Their main use is on food crops. More needs to be understood about the toxicity of OP pesticides for accurate risk assessment. Recent studies have measured the dialkyl metabolites of OP pesticides in urine to assess the exposure to the parent pesticide compound on fruit consumed. These studies used the default assumption that the metabolites only formed in the body and were not present on the fruit consumed, and that exposure came only from the parent compound. This study presented here was conducted to determine the amount of an OP insecticide azinophosmethyl, common name Guthion, and its metabolites: dimethylphosphate, dimethyldithiophosphate, and dimethyldithiophosphate on apples collected at harvest from Hood River, OR. The samples were cleaned, extracted, derivatized, and analyzed on the GC with a nitrogen phosphorus detector. The presence of the metabolites on the apples may indicate that the previous methods for calculating exposure to the parent compound overestimated the exposure. Further studies may need to take the presence of the metabolites into account in their risk assessment.
Key words: organophosophate, azinophosmethyl, pesticide, risk assessment