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RP5 Endocrine Disruption and Pharmaceutical Issues
(MIL-1117-722556) Extrapolation of a molecular response to population impacts: vitellogenin in fish.
Miller, D.1, Jensen, K.2, Villeneuve, D.2, Ankley, G.2, 1 US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, MidContinent Ecology Division, Grosse Ile, Michigan, USA2 US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, MidContinent Ecology Division, Duluth, Minnesota, USA
ABSTRACT- A challenge in the field of ecotoxicology is the linkage of alterations at molecular and biochemical levels of organization to adverse outcomes in individuals and populations. In the present study, a predictive relationship between decreased vitellogenin concentration and decreased fecundity in female fathead minnows (Pimephales promelas) was derived from short-term, 21-d laboratory toxicity tests with fadrozole, 17-trenbolone, 17-trenbolone, prochloraz, fenarimol, and ketoconazole exposures. The relationship between decreased vitellogenin and decreased fecundity at the organismal level was utilized within a population model to translate changes in vitellogenin concentrations of the female fathead minnow to alterations in population growth rate. Application of the model requires only a life table, a measure of carrying capacity for a given population of interest, and estimation of vitellogenin concentrations within the fish of the study population. Example applications are provided using different projection scenarios for a population of fathead minnows exposed to chemical stressors that reduce vitellogenin concentrations in the female, decrease fecundity, and thus reduce recruitment to a population. This research approach could be applied to other species as a population-level analysis tool for use in interpreting the effects of multiple stressors that have a common measurable organismal level effect. This abstract does not necessarily reflect EPA policy.
Key words: fathead minnow, vitellogenin, fecundity, population projection
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