|
(T/EH036) Histopathological effects of two species of Plankthotrix in mice. Nogueira, Isabel1, Cerqueira, Manuela1, Vasconcelos, Vítor1,2, 1 2 ABSTRACT- This study describes the histopathological effects in mice of two cyanobacterial species: Plankthotrix planctonica and Plankthotrix perornata. Four mice were injected with 1500 mg freeze-dried cells/kg mice and toxicity determinate by intraperiteoneal administration on mice, in 72 hours. Symptoms and death time were observed and microscopical examination of organ damage was performed. Tissue samples of liver, kidney, lungs, jejune and ceccum were examinated. Histopathological findings for the strains showed hepatocellular injury although the ratio liver/total body was not higher than that of control animals. The kidney revealed damages in cortex and medullar zone. The lungs did not show any injury. The histopathological effects found in jejune and ceccum were the most severe, including vacuolar degeneration and nucleus picnose. Half of the replicates showed for both treatments, signs of inflammatory response in the jejune. The relation between organ injury and toxin profile is aborded. Control animals injected with physiological saline did not exhibit histopathological injury in any organ. Key words: mice, cyanobacteria, toxicity, histopathology |
