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(M/MF143) Pharmacokinetic behaviour of perfluoropolyether diol originated from photochemical decomposition of perfluoropolyether derivatives and polymers.. Malinverno, G.1, Gavezzotti, P.1, Trochimowicz, H.1, Neuteboom, B.2, Triolo, A.2, 1 2 ABSTRACT- Perfluoropolyether (PFPE) derivatives and polymers are being investigated as surface treatment agents to provide oil and water repellency to many surfaces including paper in contact with food. Due to the critical application for food contact materials, it is essential to identify the ultimate bioavailable decomposition product of such chemicals. Previous studies on the photochemical decomposition of a number of PFPE derivatives such as ethoxyilated diols and phosphates esters, and on polyurethanes containing a PFPE chain have shown perfluoropolyether dimethylene diol to be the ultimate breakdown product after UV light exposure. A mechanism for the photochemical degradation has also been postulated. It is, therefore, reasonable to assume that the diol is the chemical compound that would be bioavailable to humans from the foreseen applications. In order to determine the absorption and excretion of perfluoropolyether dimethylene diol, a pharmacokinetic study with tritium-labelled perfluoropolyether diol was performed by single dermal, intravenous and oral administration to male rats. Whole blood was taken for the analyses of radioactivity at 6 times (up to 24 h) after administration. Urine and faeces were collected up to one week after administration. The radioactivity was quantified in all biological samples by liquid scintillation counting. After dermal administration no radioactivity attributable to the test compound was detected either in blood or in urine. After intravenous administration, radioactivity was eliminated from blood and the half-life was determined to be about 100 hours. Elimination occurred mainly by the faecal route. After oral administration, peak radioactivity in blood occurred 4 hours after dosing; cumulative faecal excretion one week after dosing exceeded 90% while radioactivity in urine was negligible. It can be concluded that the diol showed a very favourable ADME profile with no absorption by dermal route, only limited absorption by the oral route and a relatively short half-life in blood. Key words: perfluoropolyether (pfpe) derivatives, photochemical decomposition, absorption and excretion, tritium-labelled perfluoropolyether diol |
