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 PARENT SESSION
6A Current developments in risk assessment for pesticides
9:00 AM to 7:00 PM, Monday, 07 May 2001
(M/FF217) Organochlorine pesticides in perinatal samples of blood, adipose tissue, and milk of Nicaraguan mothers.
Dórea, J.1, Cruz-Granja, A.2, Lacayo-Romero, M.2, Cuadra-Leal, J.2, 1 2
ABSTRACT- Cord and venous blood samples collected at time of delivery of 52 mothers living in an urban and rural area of the Atoya River basin, Nicaragua. In a sub sample of 24 mothers that delivered by Cearean section, abdominal adipose tissue samples were also collected, as well as breast milk later in lactation. Cord and venous blood serum were analysed for 13 organochlorine pesticides: pp'-DDT (1,1,1-tichloro-2,2,bis (4-chlorophenyl)ethane); pp'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl-ethylene);pp'-DDD (pp'-dichlorophenyldichlorodienne);  -HCH (-hexachlorocyclohexane);  -HCH (-hexachlorocyclohexane);  -HCH (-hexachlorocyclohexane);  -HCH (- hexachlorocyclohexane); Toxaphene; Dieldrin; Eldrin; Aldrin; Heptachlor; Heptachlor-epoxide. In venous blood only pp'-DDE (100%), pp'-DDT (1.92%), Dieldrin (15.38%); Heptachlor (15.38%), -HCH (7.69%), -HCH (11.53%), -HCH (1.92%), were found whereas in cord blood only pp'-DDE (100%), pp'-DDT (3.84%), Dieldrin (19.23%); Heptachlor (9.16%) were found. The persistent DDT metabolite, pp'-DDE present in all samples of blood serum, adipose tissue, and breast milk, was studied in relation to maternal characteristics such as BMI, age, lactation experience, fetal pesticide acquisition. Mean venous (7.12  g/g) and cord (6.39 g/g) pp'-DDE concentration were not significantly different but were significantly correlated. pp'-DDE in maternal adipose tissue was positively correlated with pp'-DDE in cord blood (p=0.0001), breast milk (p<0.0001), and marginally correlated with changes in BMI (r=0.03088; p=0.06). There was a higher proportion of samples (58%) with a greater concentration of DDE in venous than in cord blood. Although DDE may not accumulate during fetal development as during breast feeding, a subtle biologic effect may occur from its exposure during embryogenesis.
Key words: organochlorine pesticides, breast milk, adipose tissue, fetus
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