|
(73-07) Effects and behaviour of antibiotics, cytostatics, disinfectans and diagnostic agents in STPs. Hüttig, Jana*,1, Gantert, Conny1, Kümmerer, Klaus1, Brückner-Nieder, Uta2, 1 Institute of Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg, Germany2 Engler-Bunte-Institute, University of Karlsruhe, Engler-Bunte-Ring 1, Karlsruhe, Germany ABSTRACT- During the last three decades, the attention concerning of the chemical pollution has focused almost exclusively on the conventional "priority" pollutants, especially acutely toxic/carcinogenic pesticides and industrial intermediats displaying persistence in the environment. This spectrum of chemicals, however, is only one piece of the larger puzzle. Another diverse groups of bioactive chemicals receiving comparatively little attention as potential pollutants are the pharmaceuticals and active ingredients in personal care products. These compounds and their bioactive metabolites are continually introduced to the aquatic environment as complex mixtures via a number of routes but primarily by both untreated and treated sewage. The pharmaceuticals may enter the aquatic environment and eventually reach drinking water, if they are not biodegraded or eliminated during sewage treatment. Only little or conflicting information is available with respect to elimination of antibiotics, cytostatics, disinfectants, diagnostic agents and their metabolites as well as their effects against bacteria in STPs. For this reason 9 substances representing the groups of antibiotics, cytostatics, disinfectants and diagnostic agents were selected for testing biodegradability and toxic effects against bacteria in simulation sewage treatment plants according to the OECD guideline 303A (1981, Simulation Test - Aerobic Sewage Treatment). Metabolites were identified with HPLC and GC-MS methods. The microbial populations shift was studied in situ using chemotaxonomy, ubiquinone and polyamine profiles. The concentrations received were compared with results of multimedia models (EUSES and GREAT-ER). The investigations are supported by the Deutsche Forschungsgemeinschaft (Grant No. KU 1271/2-1). Key words: pharmaceutical, STP, environmental bacteria |
