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(80-56) Environmental Risk Assessment of Two Model Fragrance Materials Following the RIFM Framework. Salvito, Daniel*,1, 1 Research Institute for Fragrance Materials, Hackensack, NJ, USA ABSTRACT- The RIFM Framework for prioritizing fragrance materials for aquatic risk assessment (accepted for publication Env Toxicol Chem) establishes a hierarchy of materials that are indicated to have PEC/PNEC ratios greater than 1 calculated using conservatively designed QSARs for both fate and effects in freshwater systems. Two model compounds, acetyl cedrene and, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-ethanone (OTNE), were shown to have PEC/PNEC ratios >1 in an initial assessment using only the reported log Kows of the materials in the model calculations. Further risk assessment refinement using measured ecotoxicological endpoints and wastewater treatment plant concentrations resulted in freshwater PEC/PNEC ratios for acetyl cedrene and OTNE of 0.13 and 0.11, respectively. Key words: risk assessment, fragrance materials, model |
