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(18-62) Effects of Alkylphenol Compounds on Endocrine Systems in Goldfish (Carassius auratus). Ishibashi, Hiroshi*,1, Tachibana, Katsuyasu1, Tsuchimoto, Mutsuyosi1, Soyano, Kiyoshi1, Tominaga, Nobuaki2, Yamaguti, Akemi2, Matumura, Naomi3, Tomiyasu, Yuki3, Arizono, Koji3, 1 Graduate School of Science and Technology, Nagasaki University, Nagasaki, Japan2 Department of Chemical and Biological Engineering, Ariake National College of Technology, Omuta, Japan3 Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan ABSTRACT- Various environmental chemicals are known to affect the development and function of endocrine systems in wildlife and humans. Over 70 chemicals have been labeled as potential endocrine-disrupting chemicals. Alkylphenol compounds, such as nonylphenol (NP) and 4-t-octylphenol (4-OP), also are shown to have estrogenic activity in vitro and in vivo, which may disturb reproductive function in fish. In this study, the effects of NP and 4-OP on endocrine systems (plasma estradiol-17beta, testosterone and 11-ketotestosterone) and plasma vitellogenin production in goldfish (Carassius auratus) were investigated. In addition, we also compared with the change of plasma steroid hormones and vitellogenin after NP exposure in male goldfish fed a diet with a high content of phytoestorogens, such as genistein and daidzein. Key words: Endocrine disruptor, Alkylphenol compounds, Steroid hormones, Vitellogenin |
