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(85-04) The predicted no-effect concentration (PNEC) of pharmaceuticals found in Sewage Treatment Plants (STP) effluents: extrapolation from a battery of bioassays and first approach of the risk assessment. Ferrari, Benoît*,1, Paxeus, Nicklas2, Lo Giudice, Roberto3, Pollio, Antonino3, Garric, Jeanne1, 1 CEMAGREF 3b, quai Chauveau, Lyon, France2 GRYAAB, Göteborg, Sweden3 University of Naples, Vincenzo Techio 80, Naples, Italy ABSTRACT- In the framework of the European project REMPHARMAWATER (Ecotoxicological assessments and removal technologies for pharmaceuticals in wastewaters), a monitoring campaign on STP effluents was carried out in four European countries (France, Greece, Italy and Sweden). More than 20 individual pharmaceuticals belonging to different therapeutic classes were found. For three of identified pharmaceuticals (Carbamazepine, Diclofenac and Clofibric acid), acute and chronic tests of ecotoxicity were performed on bacteria, algae, microcrustaceans and fishes in order to calculate their PNEC. Finally, a first approach of risk characterization has been performed in order to predict the incidence of the effect of Carbamazepine, Diclofenac and Clofibric acid in the aquatic compartment. In this case of study, risk has been estimated by using the MEC (measured environmental concentration)/PNEC ratio, where the MEC corresponded to the maximal concentrations measured in effluents. Firstly, regarding the PNEC, Carbamazepine appears to be the more hazardous compound. Secondly, even it is shown that Carbamazepine, Diclofenac and Clofibric acid have been detected in effluents collected in STP of the participating countries, only Carbamazepine have been detected in all. Thirdly, MEC/PNEC ratios of <1 were found for the three compounds, suggesting there is no risk for the water compartment. Key words: Pharmaceuticals, PNEC, Risk, Effect |
