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(80-79) ISIS - Is the concept of bioassay-directed fractionation suitable for a risk assessment ? Biselli, Scarlett*,1, Reineke, Ninja2, Kammann, Ulrike3, Hühnerfuss, Heinrich2, Theobald, Norbert1, 1 Federal Maritime and Hydrographic Agency, Hamburg, Germany2 University of Hamburg, Hamburg, Germany3 Federal Research Centre for Fisheries, Hamburg, Germany ABSTRACT- Bioassay directed fractionation (BDF) has gained increasing attention for identifying toxic compounds in environmental samples. It was mostly used for fresh water systems or highly contaminated samples. The research project ISIS (Identification of sediment bound contaminants from North and Baltic Sea) started with the question, if this approach is also applicable to marine samples. Within this project sediment samples of the North and Baltic Sea have been extracted and subjected to a three-step fractionation procedure. The resulting fractions have been investigated with biological test systems as well as with chemical methods. Advantages and limitations of BDF are discussed critically, including practical aspects. Investigation of low contaminated samples and estimation of toxic potentials in the case of the marine sediments leads to several problems. Therefore other approaches besides BDF are needed for a risk assessment. Key words: bioassay-directed fractionation, sediments, priority substances, risk assessment |
