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4E - Food Safety (TH9/3) Worker exposure scenarios and modelling for biocidal products. van Hemmen, Joop J1, 1 TNO Chemistry, Zeist, Utrecht, Netherlands ABSTRACT- Under current European and national legislation in Europe, biocidal products must be registered based on a risk assessment for humans, animals and the environment. Especially human exposure assessment shows many knowledge gaps, which make it hard to properly assess health risks for many biocidal application scenarios. An EU-funded project (B4-3040/2000/291079/MAR/E2) has tackled this issue and guidance has been developed to deal with the problem in an appropriate fashion. The aims of this project were: - to develop relevant exposure scenarios of humans to biocidal products; - to develop operational predictive model(s) and guidance on how to use these for the purpose of registration of the various biocidal active substances in the many different use and exposure scenarios identified. For some tasks the database provides an adequate series of study results, meaning that for that task a predictive exposure model is developed. Further, a matrix was developed with two axes: one for width of distribution and one for central tendency of distribution. All available study results were entered in the matrix at the right cell(s). Starting from this matrix , a Bayesian approach for modelling, which combines objective and subjective data, using all the databases concerned, is developed and it will be subject of validation exercises in the near future. The project has resulted in a Technical note for Guidance: Human exposure to biocidal products. Partners in the project: TNO Chemistry, Zeist, the Netherlands (project co-ordination; Finnish Institute of Occupational Health, KRIOH, Kuopio, Finland; Health and Safety Executive / Laboratories, Bootle/Sheffield, UK; Institute of Occupational Medicine, Edinburgh, UK; Bundesanstalt fuer Arbeitsschutz und Arbeitsmedizin, Dortmund, Germany; Rijksinstituut voor Volksgezondheid en Milieu, Bilthoven, the Netherlands; CEFIC representatives from BAYER, Germany and Rohm & Haas, France. Key words: worker exposure modelling, biocidal products, risk assessment |
