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5B a - RA/ Ranking and Chemical Specific (TUP/207) Environmental safety assessment of zinc pyrithione (ZPT) in down-the-drain cosmetic products. Sabaliunas, Darius1, Turley, Patricia 2, Fendinger, Nicholas3, 1 Procter & Gamble Technical Centres, Egham, Surrey, United Kingdom2 Arch Treatment Technology, Cheshire, CT, United States3 The Procter & Gamble Company, Cincinnati, OH, United States ABSTRACT- Zinc pyrithione (ZPT) is a bactericide and fungicide effective against a wide spectrum of molds, yeast as well as gram-positive and gram-negative bacteria. Its mode of action is based on disruption of the proton gradient across the cell membrane and inhibition of solute transport. Apart from its use in marine antifoulant paints and architectural paints, ZPT is also used in a variety of cosmetic products as an antidandruff agent and a cosmetic preservative. The use in anti-dandruff shampoos and conditioners represents by far the most significant cosmetic use of ZPT. This paper presents the environmental safety assessment of the use of ZPT in down-the-drain cosmetic products. The assessment is based on a vast amount of environmental fate and effect data available on ZPT, and it uses both the standard risk assessment methodology described in the EU Technical Guidance Document as well as higher-tier approaches such as probabilistic methods to derive the predicted no-effect concentration (PNEC). The predicted environmental concentration (PEC) is calculated byby GREAT-ER, the Geo-Referenced Environmental Assessment Tool for the European Rivers. The results of this assessment show that environmental risks associated with current usage of ZPT in down-the-drain consumer products are minimal, with the estimated ratio of PEC/PNEC below one under all exposure scenarios. Key words: fungicide, bactericide, GREAT-ER, risk assessment |
