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2B - Natural Stressors and Toxicants (TUP/64) Brominated indols and phenols in the German Bight and their effect on zebrafish embryos. Kammann, Ulrike1, Vobach, Michael1, Biselli, Scarlett3, Franke, Stefan2, Heinzel, Nicolas2, Huehnerfuss, Heinrich2, Reineke, Ninja2, Theobald, Norbert3, 1 Federal Research Centre for Fisheries, Hamburg, Germany, Germany3 German Federal Maritime and Hydrographic Agency, Hamburg, Germany, Germany2 University of Hamburg, Hamburg, Germany, Germany ABSTRACT- Studies of pollutant impact on the marine environment assume that contaminants are anthropogenic in origin. However, some organobromine compounds are produced naturally by common polychaete worms, algae and other organisms. Many of these organobromine compounds have been suggested to exhibit antimicrobial or other biological activities. Brominated indols and phenols have been detected in water and sediment extracts from the German Bight. The early life-stage test with zebrafish (Danio rerio) embryos was used to assess the developmental toxicity of these compounds. Brominated compounds lead to lethal as well as to different non-lethal malformations of zebrafish embryos. Comparison of EC50 of several brominated compounds in the fish embryo test with the concentrations determined in sediment and water samples suggest a potential toxicity of these substances to early life stages of marine fish species in the German Bight. Key words: zebrafish, brominated compounds, sediment, water |
