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5B a - RA/ Ranking and Chemical Specific (TUP/205) Comparisons of Accelerated Life Test (ALT) Models with Mechanistically-based Models for the Analysis of Dose-time-response Data. Ren, Shijin1, 1 University of Tennessee Center for Environmental Biotechnology, Knoxville, Tennessee ABSTRACT- Mechanistically-based models have been used for the analysis of environmental toxicity data. However, while their model parameters are usually interpretable, such models are complicated and requires specialized knowledge to derive. Well-established statistical models (Weibull, lognormal, etc.) have long been used for industrial reliability study and have been incorporated into environmental risk assessment. In this study, several dose-time-response data sets found in the literature were analyzed using accelerated life test (ALT) models. The results of the ALT models were compared with the more complicated toxicokinetics-based models and the observed data. It was found that although the ALT models were relatively simple, they provided satisfactory model fitting, especailly at low to moderate doses. It was observed that the ALT models may not hold at high doses due to a potential change in failure mode, which may also be a factor that affected the performance of the mechanistically-based models at high doses. Key words: accelerated lift test, risk assessment, dose-time-response |
