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1H a/b/c - Pesticides, pharmaceuticals, perfluoroalkylated substances, antibiotics (WEP/30) Pharmaceuticals in a coastal region of the Baltic Sea. Bruhn, Regina1, Dorka, Christine1, Iris-Constanze, Beck1, 1 GKSS Research Center, Geesthacht, Germany ABSTRACT- In recent years research on the occurrence, fate and ecotoxicological risk of pharmaceuticals in the aquatic environment is of increasing importance. Pharmaceuticals are prescribed in European countries in the amount of tons per year e.g. analgesics, lipid regulators, antibiotics, antiphlogistics or antiepileptics. Due to insufficient removal rates these chemicals reach the environment mainly through sewage treatment effluents. Several studies reported on concentrations of pharmaceuticals in surface or ground water, but little is known about their occurrence and behaviour in marine systems. This study was initiated to investigate human pharmaceuticals in the coastal zone of the Baltic Sea. A method has been developed for the simultaneous analysis of selected compounds (bezafibrate, gemfibrozil, clofibric acid, sulfamethoxazole, roxithromycin, diclofenac, ibuprofen, naproxen, propyphenazone, carbamazepin, ethinylestradiol). The method involves an extraction step of large volumes (approximately 50 L) by solid phase extraction on a polymer phase (Oasis HLB) and the identification and quantification by LC-MS/MS. Extraction efficiency has been tested on the basis of experiments with deionised water and artificial sea water. The analytical methodology and results on samples from a station of the inner Wismar Bay which is situated in the vicinity of a sewage treatment plant and from stations more remote from the potential source ( the outer Wismar Bay as well as from the Bay of Mecklenburg) will be presented. Key words: Baltic Sea, Pharmaceuticals, LC-MS/MS |
