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2L - Immunotoxicity - genotoxicity - ED (WEP/106) Toxic and endocrine effects of three nonylphenol isomers. Preuß, Thomas1, Coors, Anja1, Ratte, Hans Toni1, 1 Aachen University, Department of Biology V, Worringerweg 1, Aachen, 52056 ABSTRACT- Acute toxic effects of nonylphenol have been reported for algae, invertebrates, and fish. Estrogenic effects of nonylphenol (NP) in fish and amphibians have also been described. NP is mainly used as an intermediate for the production of nonylphenolpolyethoxylates (NPEs), which are used as detergents, polymers, antioxidants and in pesticide formulations. Most of NP and NPE are released through sewage treatment plants, although NPE is mostly degraded by microbial activity into the more estrogenic NP in the sewage plant. Due to the synthesis process, the technical nonylphenol consists of a mixture of about 20 isomers. Three single NP isomers were synthesized (Vinken et al. 2002) and their toxicity on Scenedesmus subspicatus, Daphnia magna and Danio rerio was characterized by standardized test procedures. Endocrine activity of single isomers in comparison to the technical mixture were tested using an estrogen sensitive human reporter gene cell line (MVLN). The knowledge of the toxicity of single isomers may help in the assessment of the ecotoxicology relevance and behaviour of the technical NP mixture. Key words: isomers, nonylphenol, toxicity, endocrine disruption |
