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4B - Human health and environmental connections (WEP/200) Arsenic accumulation and acute toxicity in milkfish (Chanos chanos ) from blackfoot disease area in Taiwan. Lin, M.-C.1, Cheng, S.-H.1, Lin, H.-Y.1, Chen, Y.-C.1, Chen, Y.-P.1, Liao, C.-M.2, Liu, C.-W.2, 1 Nanhua University, Chiayi, Taiwan2 National Taiwan University, Taipei, Taiwan ABSTRACT- Bioaccumulation and acute toxicity of Arsenic (As) in cultured milkfish (Chanos chanos) from the ponds in blackfoot disease (BFD) area were studied. The bioconcentration factor (BCF) of milkfish was calculated from the ratio of the As concentration in the fish to that in the water from the pond. The tolerance of As toxicity was examined by exposing the fish to varied concentrations ranging from 0 to 1000 mg ml-1 As, under laboratory conditions. The resulting value of BCF for the milkfish was 112.66© 17.74 mg g-1, indicating that the consumption of As-polluted milkfish from BDF area might pose a risk to human health. The median lethal concentration (LC50 value) for milkfish showed a significant allometric, negatively correlation with the exposure time as LC50 (t) = 134.69t-0.7175, where LC50 (t) is the median lethal concentration (mg ml-1) and t is the exposure time (hr). Exposure concentrations followed by exposure times to deaths are associated with internal lethal concentrations in fish. Lethal internal residue of As in fish body that causes 50% mortality (CL, 50 value) is a liner function of As concentration in water as CL, 50 = 63.972+0.9202Cw, where CL, 50 is the lethal internal residue of As in fish body that causes 50% mortality (mg ml-1) and Cw is As concentration in water (mg ml-1). It showed that the CL, 50 value increased with Cw; whereas the time to death of the fish was decided by the As concentrations in the target tissues of fish. Key words: arsenic, Acute toxicity, blackfoot disease, milkfish |
