|Back Topic Categories Search Previous Abstract Next Abstract|
LE Gray Jr1 *, M Price1 , C Lambright1 , C Wolf1 , A Hotchkiss2 , L Parks1 , J Ostby1
USEPA, EB, NHEERL, Research Triangle Park, NC 1
North Carolina State University, Dept Zoology, Raleigh, NC 2
Antiandrogenic chemicals alter sexual differentiation by a variety of mechanisms and, as a consequence, they induce different profiles of effects. Here, we describe the effects of 10 known or suspected antiandrogens including vinclozolin (V, 3-200 mg/kg/d), procymidone (P, 25-200), iprodione (I, 100), chlozolinate (C, 100), linuron (L, 100), p,p' DDE (100), ketoconazole (K, 12-100), dibutyl (DBP, 500) and diethylhexyl (DEHP, 750) phthalate, and the Leydig cell toxicant ethane dimethane sulfonate (EDS, 50). Dose response studies also were conducted with V, P, K, L and DBP. Anogenital distance (AGD), nipple/areola development and reproductive organ weights were measured in male offspring. Six of the 10 chemicals altered male sexual differentiation (V, P, DBP, DEHP, L, and DDE). V, P, p,p'-DDE and L are AR antagonists, while DBP and DEHP do not appear to be AR ligands. The AR-ligands, V, P, and DDE all produce a
This abstract is being presented on Monday, August 2 at 8:00 AM to 10:15 AM at CUB 2nd Floor Ballroom.