Submission Number: SHA-4-330-158

Abstract Number: 8

AN INTEGRATED ONLINE RESOURCE FOR THE BIOMEDICAL COMMUNITY:THE MOUSE GENOME DATABASE.

DR Shaw, JA Blake, JA Kadin, MT Davisson, JE Richardson, JT Eppig and

The Jackson Laboratory, Bar Harbor, ME 04609 ¹

Abstract:
From azh, "abnormal spermatazoon head shape" to Ube1y1, "ubiquitin activating enzyme E1, Chr Y", the Mouse Genome Database (MGD, http://www.informatics.jax.org) can provide information to researchers on the current nomenclature, functional gene descriptions, references, and DNA and protein sequence links to specific genes of reproductive interest. Importantly, MGD stores comparative species data for mammals, including both model organisms and agriculturally important mammals, with links to species-relevant data sources.

The full range of MGD information includes genomic, structural, and phenotypic data on gene definition, identification, classifications and nomenclature; genetic, cytogenetic, physical, and (species) comparative maps and data supporting those maps; clones/ESTs/probes/PCR characterizations and sequence links for DNA and proteins; allelic polymorphism data; mammalian homologies for model organisms and domestic species; descriptive phenotypic information for genes, mutations, and mouse strains; and reports of the mouse Chromosome Committees. Other integrated data sets include gene expression data and annotations on mouse sequence produced in large-scale sequence analysis projects. MGD is richly interconnected with other online resources such as GenBank, SWISS-PROT, PubMed, OMIM, and databases for other species, including GDB, RatMap, SheepBase, PiGbase, BovMap, FlyBase, etc. New initiatives to annotate gene function in collaboration with other model organism databases will allow cross-species queries and comparisons on the functional level.

MGD continues to evolve, expanding its data coverage, improving data handling, and providing new data manipulation and display tools to meet the needs of the scientific community. Demonstrations of MGD will emphasize its utility in reproductive research.

MGD is supported by NIH grant HG00330 to JTE. .

Keywords: genome database

This abstract is being presented at: 8:00 AM in session:
EDUCATIONAL/MULTIMEDIA PRESENTATIONS