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THE INFLUENCE OF INTRAUTERINE ANTIMICROBIAL TREATMENT ON BOVINE ENDOMETRITIS.
Ghasemzadeh-Nava, Hamid1, Esmaili, Javad2, Malekan, Mahyar2, Bokaie, Saeed1, Gharagozloo, Faramarz1, 1 2
ABSTRACT- The purpose of this study was to determine whether intrauterine infusion of antimicrobial agents in a new method, in cows with endometritis, were more effective than that of control group( PGF2
). The clinical response was assessed by inspection of clean estrus discharge. The cows ( n =111 ) were examined by rectal palpation and visual inspection of the vagina and cervix by use of a speculum on approximately 30 days after calving onward. Endometritis was diagnosed and graded on the basis of observing cloudy discharge (grade I ) or mucupurulant discharge (grade II ). Each case was randomly allocated to one of three treatment groups: A) Intrauterine infusion of 2500 mg oxytetracycline on two consecutive days, the treatment repeated once more one week later, if needed. B) Intrauterine of 100ml povidone-Iodine 5%, time sequence was as group A. C) Two intramuscular injection of 500 microgram Cloprostenol (a synthetic analogue of PGF2) in 12 days apart (positive control group). The success rates for each treatment were 14/38 ( 36.8% ) in group A, 10/36 ( 27.8% ) for group B, and 21/37 ( 56.8% ) for group C. Significant differences were obsereved between group A and B in respect to control group ( p<0.05 ). The results also showed, after treatment, there was not any significant difference in each group and among three groups on the basis of clean estrus mucus of grade I and II endometritis. A possible low cure rate in group A and B in comparison with control group (C) may be due to large doses of these antimicrobial agents (in our new method of treatment) which might impair the leukocyte function. New work is being done to determine other possible factors influencing these results.
KEY WORDS: bovine, endometritis, antimicrobial , PGF2