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EFFECTS OF (+)-Z-bisDEHYDRODOISYNOLIC ACID ON THE RAT PROSTATE.
Henry, Nancy1, Hou, Yuqing3,4, Roeder, Mikelle1, Feldmeier, Jennifer1, Patton, Jeanine1, Banz, William1,2, Adler, Stuart2, Meyers, Cal3,4, Winters, Todd1, 1 3 4 2
ABSTRACT- (+)-Z-Bisdehydrodoisynolic acid (BDDA) is a non-steroidal estrogenic compound demonstrating selective estrogen receptor modulation (SERM). Our objective was to determine the effects of BDDA on the dorsal (DL), ventral (VL) and lateral (LL) prostate lobes and the testes (TS) and seminiferous vesicles (SV) of 10-wk-old Sprague-Dawley rats. Treatments (n = 5) included 0.15 
g/g body weight daily of oral or subcutaneous BDDA or vehicle (0.10 mL of 10% ethanol:90% sesame oil) or oral estradiol for 2 wk. The rats were humanely sacrificed and the appropriate organs collected, weighed and preserved. Given orally or s.q., BDDA was equal to estradiol in reducing weights of the VL, total prostate, SV (all P < 0.001) and DL (P < 0.015), relative to the controls. However, given orally, BDDA did not (P > 0.10) reduce TS size, whereas s.q. BDDA and estradiol shrank (P < 0.005) TS by 12 and 18.5%, respectively. There were no (P > 0.10) treatment effects on the LL. These results indicate that BDDA is orally active and may be preferable to estradiol as a potential therapeutic for prostatic disease. This work was supported by the Meyers Institute for Interdisciplinary Research in Organic and Medicinal Chemistry.
KEY WORDS: Bisdehydrodoisynolic Acid, Prostate, Selective Estrogen Receptor Modulator, Rat