PARENT SESSION

(W267) BISPHENOL A INCREASE STEROIDAL HORMONE SECRETION OF TESTES.

Gharravi, Anneh¹, Ghorbani, Rostam¹, Khazaei, Mozaffar¹, Al Agha, Mohsen¹, Ghasemi, Jahanbakhsh², Sayadi, Parviz¹, Pourmotabbad, Ali ¹, ¹ Kermanshah University of Medical Science, Kermanshah, Iran² Razi University, Kermanshah, Iran

ABSTRACT- Introduction: Bisphenol A (BPA) is a xenobiotic estrogenic compound. This compound has suspected to have estrogenic effects on reproductive system of male and female. In this present study, we investigated possible low dose effects of BPA on testosterone hormone MATERIAL, METHODS: Male wistar rats (12-13 week old) were administrated a daily intra peritoneal 10g/kgbw/day, 50g/kgbw/day, 100g/kgbw/day dose of BPA for12 days and one day after last injection serum level of testosterone examined. All data expressed as means and SE. one-way ANOVA performed. RESULTS: Analysis of data showed, in100g dose group, serum level of Testosterone Hormone (5.880) significantly increased in compare with control group (2.900). CONCLUSION: The present study showed that BPA at low doses affects steroidgenesis in testicular Leydig cells, and subsequently alters the secretion of Testosterone Hormone, one of main hormone in spermatogenesis in the adult wistar rats.

KEY WORDS: bisphenol A, testosterone hormone, spermatogenesis