Minisymposium II. Non-Genomic Actions of Sterioids in Reproductive Tissues
Chair(s): Stormshack, Fredrick1, 1 Oregon State University, Corvallis, OR
Location: CCQ 2000A
(MS4) MEMBRANE ACTIONS OF SEX STEROIDS IN NEURONS: IMPLICATIONS FOR GENOMICS AND BEHAVIOR.
Vasudevan, N.1, Kow, L1, 1 The Rockefeller University, New York, NY
ABSTRACT- Historically, genomic and membrane actions of steroid sex hormones were thought to be alternatives to each other, mechanistically unrelated and controversial. However, in a neuroblastoma cell line, we found that membrane-initiated actions of an estrogen could actually potentiate later genomic actions mediated by a consensus ERE (PNAS, 2001). The data offer the possibility of a unified view of estrogenic action in nerve cells. Multiple signal transduction systems are involved in this phenomenon, with the interesting characteristic that some are both necessary and sufficient. The membrane action's facilitation of estrogen actions in the nucleus holds true in hypothalamic neurons, as demonstrated by mating behavior measurements (PNAS 2004). Surprisingly, thyroid hormone can substitute for estradiol in the first pulse (PNAS, 2005). Both the logic and the quantitative features of sex hormone actions in neuronal membranes are more complex than anticipated.
KEY WORDS: membrane actions, sex steroids